DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and frem1b

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001131130.1 Gene:frem1b / 557221 ZFINID:ZDB-GENE-050208-783 Length:2167 Species:Danio rerio


Alignment Length:2240 Identity:437/2240 - (19%)
Similarity:772/2240 - (34%) Gaps:698/2240 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 RLISKGLRINE-----ISFKGCMRDILVNDLPLGFAEMTISRSLALNC--------------LWK 387
            ||:|..:.:..     :...|.|.|.......:.|.:....|..|:.|              ..|
Zfish   172 RLLSSEISVPALGQLVVEESGTMVDTEAGPRKVFFCQFFFGRHTAIACPGNKACDLKTRQVEFLK 236

  Fly   388 YPCVEYNPCLKSGICSQH------GVDGFICYCDQSYCIKADFQG-PFKIFTET-SPELELLYVS 444
            ..|.|:   |.||:..||      .:|    |..    ::.:|:. ..:...|| |..|.:|...
Zfish   237 TDCSEF---LSSGLKYQHLSPPSPEID----YIP----VRLEFRDQTSRALLETESVWLPVLIQG 290

  Fly   445 PMQLLEGGTAFLSPHFIDI-----------ILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEK 498
            .||......||:|...:::           .||.:...:..:| :||.|...|..|.:.......
Zfish   291 AMQNQPPHAAFMSTFILEVDQFILTPLSTAALDAKDDETPQDQ-LIFSVTKPPAEGYITHLDDHT 354

  Fly   499 AIFVPCRTFNLVDLATDKLKY-----VHNGQENFN-DHATLDMQIFGDVHKIPENILGKHRFLLH 557
            .:   ..:|:..||...|:.|     .|..:.|:. :...:|...   ...:|        .|:|
Zfish   355 KM---ASSFSWQDLNEMKIAYQPPNSSHTARRNYEVEFQAIDGSF---APSLP--------ILMH 405

  Fly   558 ANI-TPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCF 621
            .:| |...:.|  |:..:..|.::||..|.:..:...|.|.|:...   .|::....|..  |..
Zfish   406 ISIRTAETNAP--RVSWNMGLDLLEGQSRPITWEHLQIVDKDNIDA---VTLIAMDGPLN--GHL 463

  Fly   622 IVGGATTSAFSQAEVNVGKVSYLY-NSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLELR-- 683
            .|.|.....|...::..|.|.|.: :|.|...:   :..:::||..:....: |:.:.|.:..  
Zfish   464 SVRGGKGFMFKVKDLREGVVVYHHSDSDTTRDY---VVFRITDGRHSIRHKF-PIYILPKDDTPP 524

  Fly   684 -LVNNT-------GLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGS 740
             |:||.       |.:.:.:..|..|..:.|      ||:  |:|.::..|:.|.|.:.......
Zfish   525 FLINNVAFEVQEGGTVRVEEYMLMASDLDSS------DDY--IQYQLITFPRAGQLIKKSSPHEP 581

  Fly   741 WVNVDWFSDSQLLLGHIRYLHSSDFPWQDEFKFIAS----------FGFVTTQTFDFRITFTRLR 795
            .:.|..|....|..|.|.|.||.:..::|.|.||.|          ...|....|..:.... :.
Zfish   582 GLPVKSFLQRDLFQGLIYYKHSGEEVFEDSFDFILSDVHQPPNLSDRHTVVIHVFPVKDQLP-VE 645

  Fly   796 ITSTRPSQISINGSREILLTSDVLSYETTPIGSFARSVIYKITKP------TRY---GGIYVEGS 851
            ::.|..| |::..:..:.:|..:|.:..|....  ..::|.||.|      ||.   |.::...|
Zfish   646 VSGTVRS-ITVKETEVVYITQSLLHFRDTEHPD--TDLMYVITHPCFSPGNTRLSDAGRLFYTDS 707

  Fly   852 RKAAKK------LDSFTQQDIEKRRIRYQTHHTSYSSF--------SDH---------------- 886
            ..|.||      |.||||..|   .::|....:|.||.        :.|                
Zfish   708 TNAMKKDAMVPVLKSFTQHFI---NVQYHFAASSVSSLFCCPQHAVNHHKVAYMPPIEDIGPEPL 769

  Fly   887 -LEFVVSVAECDDVAGVL-----EINYRPPD----ELINKLGYQNHEPLQVQEGERALITKNHFG 941
             ::||.||:  |...|.|     .|...|.|    |:...|       |:|:||..:.:.:.|..
Zfish   770 FVQFVFSVS--DHQGGALTGLTFNITVTPVDNQAPEMFTNL-------LRVEEGGGSFLMEEHLL 825

  Fly   942 IR--FNIYESLQFQVSLSPEHGVICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTESTRDTFE 1004
            ::  .:..:.|:..:...|:||   :.:.|.......:.|||..|....:.|.|||:|:.:|:..
Zfish   826 VQDVDSSEDQLRIHMKTKPQHG---RLELQGTAMLEGDSFTLRDLKALRVRYIHDDSETQKDSIG 887

  Fly  1005 LLILSGDETDLQFVSN----MEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDA-DV 1064
            |.|..|       :::    :.:.|..|||..|...:..:.....:.|.:.  ...::||.| ||
Zfish   888 LTITDG-------INSAHGALLIQILPVNDEPPQLGSDLKAKLSCKEGGQV--QITVEYLSATDV 943

  Fly  1065 NTNHTDIHYIHVSST-NGAFYKSGHYIDSFTQDDIANRRIMFQHTGADSG------TASFIVTDR 1122
            :::.|.:.|:...:. .|...::|..:|.|:|.|:.|..|.:.|||.:.|      |.:.||:|.
Zfish   944 DSDDTRLTYMLARTPGRGVIQRNGVTVDKFSQLDVLNGLIFYLHTGGEIGPDPVSDTVTLIVSDG 1008

  Fly  1123 E-HEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKLDEIYYEVIKPPSYG 1186
            | ..::|..:..|..|.|.:..|                                     .|.|.
Zfish  1009 EAGTMDGCCQEDALPPPVPLHGT-------------------------------------LPVYD 1036

  Fly  1187 ILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMDKVRYRVHIKNITAEG 1251
            :                          |.|.:.:..:                    :..||..|
Zfish  1037 L--------------------------NITVMPVNNQ--------------------VPTITLGG 1055

  Fly  1252 EVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYLE- 1315
            .::                     |:|.....:...|||...|:..|.::.|.:.:.|.:|:|| 
Zfish  1056 MIV---------------------VDEGARACLCGGVLEASDPDSRPEELMFHLVTPPQYGFLEN 1099

  Fly  1316 -MQSMSFDDE---YNCKVFDQSSVNTEKMFYIQA---GVNQSTDYFVFDVTNGITWLRQLMIKIV 1373
             :.|..|:..   .....|.|..:::..:.|:|:   ||..:.|:|...|::|:.....|.:.|:
Zfish  1100 TLPSPGFEKSNAGLRVVFFSQLHLSSGFINYVQSVHQGVEPTADFFTISVSDGMQRSAPLHVYII 1164

  Fly  1374 IIPEKLYMHSNIIS---VVEGKTVQLNPTDIQPYSEYYRGKILEYIVTITPSSGHVLAG------ 1429
            |.|....:.|.::|   |:||....|:|..:.........:.|...:...|:.|.::.|      
Zfish  1165 INPTNDEVPSLLLSNFTVMEGGMKDLSPDILNAVDVDIPAESLTLTILDPPAHGTLINGIYGLEM 1229

  Fly  1430 ------NSKV-------KRFTQKQLEQG-SIQYVHNGSENATDSITLVAMARNKESVPFELEFAV 1480
                  |.:|       :.||.::|:|| .|.|:|:.:|...|:.| :.:.....:|.......:
Zfish  1230 NRYKSMNPEVLQQTLAIQSFTLEELQQGMKIMYMHDDTETLKDAFT-IQLTDGGHTVQGTACVRI 1293

  Fly  1481 VQVNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVN----------HIYGGYL 1535
            :.||||:|.::.|.|::|....:.||.:..|.|.|.|||.::|.:::|          .:..|::
Zfish  1294 IPVNDEKPWLLKNAGVEVEALEKRVISSVVLEAGDQDTPSDHLLYILNAGPRFGLLQLRVKAGWV 1358

  Fly  1536 ARKSAPHQKIEHFTQAQINLEEIYFMHDSNS---RRNELSFVVTDGLFNTTTQMLNIEI------ 1591
              ..:|.|   :|||..:.:..:::.|.:.|   ..:...||:|||...|..|...|.:      
Zfish  1359 --DLSPGQ---NFTQEDVEMNRLWYSHTTVSGFKGHDRFHFVLTDGENTTPPQSFFISVRTVQKG 1418

  Fly  1592 ------KPIEILAEHNENLHVFPLTKKQILRDYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDN 1650
                  ||:.:|......|....||...         ......|:.|.:.|||..|.:  ..:..
Zfish  1419 DIALITKPVTLLEGERVILTTDILTAAD---------SGGRPDELIYTVAVPPEHGHL--HMVQT 1472

  Fly  1651 GFTKEVSEFTQNDVDNGHIFYEHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLL 1715
            ... .|..|:|.||....:.|.|..  ..|...|||.|                   ::|:|   
Zfish  1473 PGV-PVFSFSQMDVAANRVCYTHDN--SRFADRDSFSF-------------------AISNG--- 1512

  Fly  1716 RFLPVNKLNVDEGGSVPIKLDFSKILEYLKTKAGINNPELFIEAIQKPTHGNIGLGHEFKHMQRY 1780
                                        :.:::|                               
Zfish  1513 ----------------------------VASRSG------------------------------- 1518

  Fly  1781 HPSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCNLTIPVSINPINDQPFHLVTHLPQMTV 1845
                    .|::..:|||.:..|:                    |.|             ..:.:
Zfish  1519 --------TVHFTIEHSDRIPPTL--------------------STN-------------KGLEL 1542

  Fly  1846 VEGENRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINND 1910
            .||..:||:..:|...|.||..|.:.|.|...|..|   |:...|.|    ....:|||.||||.
Zfish  1543 TEGSMKTISTEELKLTDPDTALENLTYVVTQSPQYG---KLLFKGLP----LSKPRFTQLDINNM 1600

  Fly  1911 RIIYVHF-GMPQSTTFCFTVSDG-----------QSNPAYEIFTIKIDSIHLQPSAMQAPVKVQQ 1963
            .:.|.|. |......|.|..:||           :|:||  :|||:|:.:...|     |..:.:
Zfish  1601 DLAYQHLNGRATIDRFAFQPTDGTNKGYLEYGQLKSDPA--VFTIQIEILDKTP-----PSIINK 1658

  Fly  1964 GATTAPMRL---DHIGVSTNVHM---------ERLSYNVTNSPLFGIIVYKHQPTL-------RF 2009
            |..:....|   .|....|:..:         :.|.:.:|..|.||.:    :.||       ||
Zfish  1659 GIPSTVENLPDGKHGIYITSKELQASDPDSPDDTLEFTITRPPHFGFL----ENTLTGAFIKGRF 1719

  Fly  2010 TQQQLETSQISY-MQTDLNRSNDSFQVSAYVPGTNYVAQVDVVMEVE-PVIQINDIVMKEAESSG 2072
            ||:.::...:.| :..|:..:.|||:.....|..|.:  :..|:|:. ..:.::....:..|::|
Zfish  1720 TQKDVDQKAVRYVIPVDVEVTADSFEFQVTDPAGNTI--LPEVLELRWSRVDLSASCYRVCETAG 1782

  Fly  2073 G-KIKLITSLDNDNP--LSLKLNKFNPKFVITRMPSTGQIRKIIRSTGLTTDGQSDRSTNIFSYK 2134
            . .::::.|.::.:|  :.:::.:           .|.::.|....:..:.. |.|...|:..:.
Zfish  1783 TLAVQVLRSGNSKDPAYIGIQVEE-----------GTAKVGKDFTHSSASLI-QFDPGVNVKMWN 1835

  Fly  2135 ELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQPAQATVSIEYRSRVEETETVHLGSAGLSIN 2199
                   .::..:.:||   :|:.||  :::|.  |..|.:.                       
Zfish  1836 -------IYLKDDGLEE---NHERFD--IILKA--PKNAVLG----------------------- 1863

  Fly  2200 YLAIGCAIFIVLICLLIVLLILKIRKLRKHKADISKDQPPALPCPPDLTSVSPQHHLHHHHGHHY 2264
                                       :::||.:....|....|.||...|....:.|.:...  
Zfish  1864 ---------------------------QRNKASVEIVDPRNGRCNPDDLIVEEDENQHTYQIQ-- 1899

  Fly  2265 ASSEADSVPATGNSTPLPGFSNIPHCKIIPVESYKHEYP---DYDPDEEETDDQCDPQQMMLPQR 2326
                                   ||   ||    :.|.|   :|.|         ||:..:|.:.
Zfish  1900 -----------------------PH---IP----EPETPVLEEYTP---------DPRSGILWEN 1925

  Fly  2327 YNP-----------------YHMEHDAWSS 2339
            |.|                 .|||.:|:.|
Zfish  1926 YPPRGDVPYRTDFNHYSLTGQHMEQEAFHS 1955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058 6/27 (22%)
Cadherin_3 507..664 CDD:292802 33/164 (20%)
Cadherin_3 631..776 CDD:292802 36/155 (23%)
Cadherin_3 747..892 CDD:292802 44/194 (23%)
Cadherin_3 861..1005 CDD:292802 41/179 (23%)
Cadherin_3 979..1121 CDD:292802 41/153 (27%)
Cadherin_3 1093..1242 CDD:292802 23/155 (15%)
Cadherin_3 <1264..1361 CDD:292802 23/104 (22%)
Cadherin_3 1330..1464 CDD:292802 38/159 (24%)
Cadherin_3 1436..1578 CDD:292802 41/155 (26%)
Cadherin_3 1789..1932 CDD:292802 35/143 (24%)
Cadherin_3 2009..2163 CDD:292802 26/158 (16%)
frem1bNP_001131130.1 Cadherin_3 <315..394 CDD:292802 15/82 (18%)
Cadherin_3 360..504 CDD:292802 33/164 (20%)
Cadherin_3 473..618 CDD:292802 36/156 (23%)
Cadherin_3 747..893 CDD:292802 35/157 (22%)
Cadherin_3 862..1008 CDD:292802 41/154 (27%)
Cadherin_3 973..1152 CDD:292802 49/282 (17%)
Cadherin_3 1118..1281 CDD:292802 38/163 (23%)
Cadherin_3 1249..1399 CDD:292802 41/155 (26%)
Cadherin_3 1366..1512 CDD:292802 38/178 (21%)
Cadherin_3 1480..1623 CDD:292802 49/273 (18%)
Cadherin_3 1592..1750 CDD:292802 43/168 (26%)
Calx-beta 1766..1854 CDD:295344 14/111 (13%)
CLECT 2043..2160 CDD:214480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11789
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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