DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kon and Nrx-1

DIOPT Version :9

Sequence 1:	NP_001260539.1	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster
Sequence 2:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster

Alignment Length:	1150	Identity:	243/1150 - (21%)
Similarity:	398/1150 - (34%)	Gaps:	314/1150 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 FRTRQENAFLFLAAGRTDYCLLRLESGLISFSYKIERDVVQLR-SPKKQKLNDLEWHDVAVQR-- 116
            |||||.|..||.....|||..|.|..|.:|.:..:.....::. .|.|.:.:|.:||.|.|.|
  Fly   386 FRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRI 450

  Fly   117 --------FENNITLQVDGYIMRKQLPGDLAALNIHFGTFLGGVGDFTAEFLDDVIG------FR 167
                    |...:|:..|.|.....:.|....|: ....::||..:..|     ::|      |.
  Fly   451 QEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLS-SSRVYVGGAVNPRA-----LLGARVHTNFV 509

  Fly   168 GCISDVFYN----NINIIKRAKDRTSHTTSTG-VAWTCSTEFEGSIQDSISFMRNDSYSLMMKES 227
            ||:..|.::    |:|:|..||..:......| :.:.|.:   |..||.::|...:|:.::....
  Fly   510 GCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPS---GDPQDPVTFTTRESHLVLPPWE 571

  Fly   228 YAMGETLSLQFRTMASAGVIFFNGGYD--------FILLEIEDQHLKVTFN-KAGSLVQFMTNEH 283
            .....::|.:|||....|:|....|..        .|.:|:.:.|:.:..: .:|:.....:...
  Fly   572 TGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRR 636

  Fly   284 ISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLEKSVFFGGVQEEMRRRLISKGL 348
            :.||.||.:.||.|...|::|:|...:.:| |..:.|  .:.|:..::.|||           |.
  Fly   637 VDDGDWHDLILRRNGRDAKVSVDGVWNDFR-TPGDGT--ILELDGHMYLGGV-----------GP 687

  Fly   349 RINEIS-------------FKGCMRDILVNDLPL---GFAEMTISRSLALNCLWKYPCVEYNPCL 397
            ..|.:|             |.||:||::::...:   .||.:..|.|:..:|..:......||||
  Fly   688 AYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCL 752

  Fly   398 KSGICSQHGVDGFICYCDQSYCIKADFQGPFKIFTETSPELELLYVSPMQLLEGGTAFLSPHFID 462
            ..|.|.: |.:..||.|..:.     :.||     ....||..|            ||.....:.
  Fly   753 NGGTCLE-GWNRPICDCSATL-----YGGP-----TCGRELATL------------AFNGSQHMT 794

  Fly   463 IILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAE-------KAIFVPCRTFNLVDLATDKLKYV 520
            |.|...:......:.::.........|.||..|||       :...|..|....|.| :|:.|.:
  Fly   795 IWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRL-SDREKNL 858

  Fly   521 HNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHANITPINDPPQLRLHSHKILRVIEGIER 585
            ..||...||:         :.|.|        ||...|:        .|||
  Fly   859 LAGQSVLNDN---------NWHTI--------RFSRRAS--------NLRL-------------- 884

  Fly   586 VLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFIVGGATTSAFSQAEVNVGKVSYLYNSTTA 650
                   .:|......|.|..|||...|..|.....:.|      ...||..:...|      |.
  Fly   885 -------QVDGAPPVRGMLSETILGRHSTMEIRSVHLGG------LFHAEEEIQMTS------TM 930

  Fly   651 ESFSYELQLQVSDGIETSETV--------YLPVSVHPLELRLVNNTGLIMIHKSSLPISTANLSI 707
            .:|..::|..|.:|....:.|        .||.:...|..|.||:......|.::.....:.:.:
  Fly   931 PNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGL 995

  Fly   708 GT----NAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLHSSDFPWQ 768
            ..    |::.  ||.|:..|:.....|....|:.|        |...:|:.|||.|
  Fly   996 AMLKAYNSIS--IDFRFKTVEPNGLLVFNGGRRND--------FVAVELVNGHIHY--------- 1041

  Fly   769 DEFKFIASFGFVTTQTFDF---RITF---TRLRITSTRPSQISIN--GSREILLTSD----VLSY 821
                           |||.   .:|.   :|:.:...|..|:||.  |.:...||.|    ::|.
  Fly  1042 ---------------TFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISL 1091

  Fly   822 ETTPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRRIRYQTHHTSYSSFSDH 886
            ....:......::|       .||::.:                      .|.....|.||.|.
  Fly  1092 TGNNMHLELAGILY-------IGGVFKD----------------------MYSKLPASISSRSG- 1126

  Fly   887 LEFVVSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEG-----ERALITKNHFGIRFNI 946
            .|..::..:..|.:..|..:...|..|:          :...||     :.|...:.:...::|.
  Fly  1127 FEGCLASLDLGDASPSLTSDAVVPSSLV----------VSGCEGPTKCSQNACANRGNCVQQWNA 1181

  Fly   947 YESLQFQVSLSPEHGVICKYDE----QTGLTTPVEMFTLEQ----------------LFRNDIYY 991
            |..   :..::...|..| |||    :.|....:..:|..:                ..|.|...
  Fly  1182 YAC---ECDMTSYTGPTC-YDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVL 1242

  Fly   992 CHDDTESTRDTFELLILSGDETDLQFVSNM--------EVHIKLVNDNEPYRTAIERVFHVVRNG 1048
            ...::.:|:|..||.|:.|   ::..|.|:        |:..| ||||         .:||||..
  Fly  1243 LRVESATTQDYMELEIVEG---NIFMVYNIGSVDLPLGEIGTK-VNDN---------AYHVVRFQ 1294

  Fly  1049 IRTLNPTVLQYLDADVNTNHTDIHYIHVSST------NGAFYKSG 1087
            .:..|.| ||..|.:|.......|:..|.:|      .|.|.::|
  Fly  1295 RKGGNAT-LQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNG 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kon	NP_001260539.1	LamG	30..176	CDD:238058	37/137 (27%)
		LamG	211..365	CDD:238058	38/175 (22%)
		Cadherin_3	507..664	CDD:292802	32/156 (21%)
		Cadherin_3	631..776	CDD:292802	30/156 (19%)
		Cadherin_3	747..892	CDD:292802	29/156 (19%)
		Cadherin_3	861..1005	CDD:292802	26/168 (15%)
		Cadherin_3	979..1121	CDD:292802	32/138 (23%)
		Cadherin_3	1093..1242	CDD:292802
		Cadherin_3	<1264..1361	CDD:292802
		Cadherin_3	1330..1464	CDD:292802
		Cadherin_3	1436..1578	CDD:292802
		Cadherin_3	1789..1932	CDD:292802
		Cadherin_3	2009..2163	CDD:292802
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389	37/136 (27%)
		LamG	555..716	CDD:238058	38/174 (22%)
		EGF	746..777	CDD:278437	12/41 (29%)
		Laminin_G_2	814..945	CDD:280389	40/189 (21%)
		LamG	988..1136	CDD:238058	37/211 (18%)
		EGF	1164..1195	CDD:278437	4/33 (12%)
		Laminin_G_2	1233..1356	CDD:280389	31/119 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910