DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and Cspg4b

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001365627.1 Gene:Cspg4b / 408066 MGIID:3040697 Length:2391 Species:Mus musculus


Alignment Length:2559 Identity:657/2559 - (25%)
Similarity:1104/2559 - (43%) Gaps:403/2559 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 SLFGDGYVSMPLQEAKMSTNIRVKFRTRQENAFLFLAAGRTDYCLLRLESGLISFSYKIERDVVQ 95
            |.:|:.||.:...|.....:::::|:|.:....||||||:|||||:.|.||::.....:......
Mouse    28 SFYGESYVGLSTTEVFPELSLQLRFQTSKPQGLLFLAAGKTDYCLIELLSGILQVKINMGTGQEI 92

  Fly    96 LRSPKKQKLNDLEWHDVAVQRFENNITLQVDGYI-MRKQLPGDLAALNIHFGTFLGGVGDFTAEF 159
            |.|.::.:::||.||.:.::..::.:.|.:|.:. ...:|.|.|.....|.|.::||.|..:..:
Mouse    93 LLSEQRLRVDDLAWHSLELRYGKDAVLLVIDKHFETTVRLAGGLRNFTFHHGIYIGGRGGLSVPY 157

  Fly   160 LDDVI-GFRGCISDVFYNNINIIKRAKDRTSHTTSTGVAWTCSTEFEGSIQDSISFMRNDSYSLM 223
            ||..| .||||:.||.:|...|:...:........:.|:..|:.||.....::|||..:.|| :.
Mouse   158 LDRKIPNFRGCMEDVAFNQREILTSLRSYPGFKKVSEVSLGCNDEFFAGKDEAISFFSSRSY-VT 221

  Fly   224 MKESYAMGE---TLSLQFRTMASAGVIFFNG-GYDFILLEIEDQHLKVTFNKAGSLVQFMTNEHI 284
            ..|....||   ..::|..|: .|.::|.:| |.||:.|||.:..||....:.|:..|..:...:
Mouse   222 FPEWKVHGEGFLRFAVQTGTL-QALLLFQSGRGRDFVALEIHEGLLKAHVGRGGTKTQLSSFSLV 285

  Fly   285 SDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLEKSVFFGGVQEEMRR-----RLI 344
            ||.|||.|.|:......::.:|:...  |.....:::|.:: |..:|.||:.:.|..     .::
Mouse   286 SDNKWHVVQLKVTGRHVDIMVDEHRE--RAGLPLQSQAFVS-EGPLFMGGLDDRMWETVRGLEVV 347

  Fly   345 S-KGLRINEISFKGCMRDILVNDLPLGFAEMTISRSLALNCLWKYPCVEYNPCLKSGICSQHGVD 408
            | .|..:..:|.|||:|.:..|.......:..:||.:                  |..|:..|:.
Mouse   348 SMPGKSVRGMSLKGCLRALEANLEKRALRDALVSRDI------------------SAGCTSEGLR 394

  Fly   409 GFICYCDQSYCIKADF-----------QGPFKIFTETSPELELLYVSPMQLLEGGTAFLSPHFID 462
            |    .|.|...:..|           ..|.||.:.:     .|.::.:::.|||.|.|....|:
Mouse   395 G----TDPSVAGEDLFPPEPSSPTTIPSSPLKIQSGS-----FLVLNKLEVQEGGRALLGQRHIE 450

  Fly   463 IILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEKAIFVPCRTFNLVDLATDKLKYVHNGQENF 527
            :.:|.... .:|...|:|.:...|.:| .||..|..|..:. |||.|.||...|:.|||:|.|..
Mouse   451 VDVDFMDL-GINSSQILFKIQEMPAHG-FLQIDAWPAQEME-RTFTLSDLRHGKVWYVHDGSEEP 512

  Fly   528 NDHATLDMQIFGDVHKIPENILGK------HRFLLHANIT--PINDPPQLRLHSHKILRVIEGIE 584
            .|..|     |.......:.:|.:      |.|    |||  |:||||.|:|....:| :.|..:
Mouse   513 TDSFT-----FWAFSSSKQALLSQLQAPVPHVF----NITVLPVNDPPYLKLPEGHLL-LFENTK 567

  Fly   585 RVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETF-------GCFIVGGATTSAFSQAEVNVGKVS 642
            :.|...:..:.|||::...|.:::|...:.:..|       |..|.|      |:..::..|.:.
Mouse   568 QRLTPRVIQVLDPDTDSRRLRFSVLNNFNSEAGFLENAREPGRAITG------FTDMDLQDGNIF 626

  Fly   643 YLY----NSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLELRLVNNTGLIMIHKSSLPISTA 703
            |::    ||..|        |:.:||...|.||.|.|...|.:..:.:.||:::....::.|:..
Mouse   627 YVHRGPRNSRVA--------LRATDGELVSNTVVLRVMAVPWDFEVADRTGVVVPQGGTILITRN 683

  Fly   704 NLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLHSSDFPWQ 768
            |||:..|.....:|..|||...||.|.:|. |..:|.|..|..||...:....|||..|.....|
Mouse   684 NLSVKVNGGQHELDTLYDITHPPQFGQIQH-RGSNGEWKPVRTFSQRSIDQSQIRYYSSFKGLQQ 747

  Fly   769 ----DEFKFIASFGFVTTQTFDFRITFTRLRITSTRPSQISINGSREILLTSDVLSYETTPIGSF 829
                |.|||..:......:...|.:|...|::|..:...:.|:.:.:.:|.|..|......:.:.
Mouse   748 ENVTDHFKFRVNIEGRVGRELLFPVTVQWLQLTLLKNIPLEISNANKKVLDSGHLQAAAGSVAAP 812

  Fly   830 ARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRRIRYQTH----HTSYSSFSDHLEFV 890
            .|.:.:|:..|.:.|.:.:  ..|..|....|:|::|...::.|:..    ..|..|||  ...|
Mouse   813 ERGLHFKLLIPPKRGRLLL--GNKVLKSGSMFSQKNIADSKVSYEPQGMPGQDSQDSFS--FSIV 873

  Fly   891 VSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGERALITKNHFGIRFNIYESLQFQVS 955
            |...|..|....:::........|...|      |.|:||||.:|||:...::.......|::|:
Mouse   874 VKQVESKDHTFRIDLKADKTHVTITNTG------LYVKEGERTIITKSELFVQTLDNHVFQYKVT 932

  Fly   956 LSPEHG--VICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTESTRDTFELLI----------- 1007
            .||:||  .:.......|.......||.|.:....:.|.|||:|:..|.|.||.           
Mouse   933 KSPQHGELKLVSSSASLGSDNRATGFTDEDIVSGRLVYVHDDSEAQWDEFILLASATGLGQQGGV 997

  Fly  1008 --LSGDETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDADVNTNHTD 1070
              |..:.|..:.  .:.|.::|.||.:|.| .::::|||||:..|.|....|.|.|.|::.:...
Mouse   998 RSLDSEHTSTEI--KVSVSVELKNDEKPVR-VVDKIFHVVRDSQRLLTLADLCYHDPDIDFDDGQ 1059

  Fly  1071 IHYIHVSSTNGAFYKSGHYID---SFTQDDIANRRIMFQHTGADSGTASFIVTDREHEVNGLLEI 1132
            :.|......||...|:...|.   .|.|:|:...|::|:|.|.|.......|||..|..:.|.|:
Mouse  1060 LLYTRHGIPNGDLVKAADPIRKLYQFRQEDLREGRVLFRHHGPDFARFLIFVTDGVHYTSSLFEV 1124

  Fly  1133 RASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKLD-EIYYEVIKPPSYGILMYLSRANE 1196
            ..|:.:|.::.....:|..|:...|...:..:.||.|::.| |..:.:::||.:|.|:       
Mouse  1125 SVSEAYVRIVNNTGLLVHRGRDSFLTTANLSVTTNQDVRTDHEFEFHIVQPPKHGRLL------- 1182

  Fly  1197 GENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMDKVRYRVHIKNITAEGEVMFRIYPSA 1261
                      .|.::..:|:..|:::.|::|......::|.....|.:|:...:..:..::....
Mouse  1183 ----------VNNSTFHSFSQHDLKQGRVIYRYDGDGNLDIFNLTVKVKDAYLDVSIRVQVSSEG 1237

  Fly  1262 YWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYLEMQSMSFDDEYN 1326
            ......:..:.:|.|||...|.:||..|:..:....|.:..|.|.:.|:||||:: |.:.|....
Mouse  1238 RQRSTPILHSRSLIVEEGKPVKLSRGKLQAGNEEDIPSEAVFTVRTPPVHGYLQI-STAEDGIAG 1301

  Fly  1327 CKV-----FDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGITWLRQLMIKIVIIPEKLYMHSNII 1386
            ..|     |.|..|:...:.|:|....|..|.|..|||.....:|::.:.:..||:.:.:....:
Mouse  1302 ADVMPTLNFTQQDVDDGHVLYVQTAPGQQKDQFTLDVTKDSRVIRRVEVLLEPIPKWIPLKVQNL 1366

  Fly  1387 SVVEGKTVQLNPTDIQPYSEYYRGKILEYIVTITPSSGHVLAG---NSKVKRFTQKQLEQGSIQY 1448
            :|.||.:..|....:|..|:|..|...|:|:...|..|:|.:.   ..|:.:|:::::.|..|.|
Mouse  1367 TVQEGGSKVLLQDHLQIASKYLEGLDCEFILLEPPKHGYVESSKFPRVKLMKFSRREVAQELIYY 1431

  Fly  1449 VHNGSENATDSITLVAMAR--NKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIKNTDL 1511
            ||:|||...||:|::|.:.  .|:|.|..|...|..||||.|::..|..||||......:...||
Mouse  1432 VHDGSEEFLDSLTILANSSELGKQSPPQTLFVTVESVNDEAPVVTANNILQVWVNSVTEVTRGDL 1496

  Fly  1512 LAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIEHFTQAQINLEEIYFMHDSNSRRNELSFVVT 1576
            .|.|.|:.|::|.:.|.....|:||.||.|.::|::||||||:..::.|:| :.:.....:|.||
Mouse  1497 CAGDGDSSPQDLVYWVTPPSNGHLALKSTPGRRIQNFTQAQIDEGQLVFVH-TGAMSGGFNFQVT 1560

  Fly  1577 DGLFNTTTQMLNIEIKPIEILAEHNENLHVFPLTKKQILRDYLHFKCSDEE---REIRYNITVPP 1638
            |||.....|:.:|..:.:.|..|.|..|.:||.:.|.:....|....:|::   |.:.:.:...|
Mouse  1561 DGLNFAPRQIFSITARALIISLEVNRGLSIFPGSTKPLSSHDLRAVTNDDKAGNRTVTFTVVRSP 1625

  Fly  1639 SLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEHTAVIME---FRTNDSFYFDVVAERSDRLLN 1700
            .|||::....||. |::||.|||..|..|.|.|:|  |.:|   :.:.|||.|...:..:: |..
Mouse  1626 KLGRLLKMNPDNR-TEDVSTFTQCLVSEGLILYQH--VDLESTGWASEDSFTFTASSPPAE-LGP 1686

  Fly  1701 QKFNIEIS--VSSGGLLRFLPVNK-LNVDEGGSVPI---KLDFSKILEYLKTKAGINNPELFIEA 1759
            :.|.|.||  |:..|....|..|. .:|.||..|.|   |||.|.:|..| .:...::.|::.:.
Mouse  1687 EAFRITISYEVNESGRQSRLRANTGASVKEGDKVLIDQSKLDASNLLLQL-PQPQRSSHEIWFQV 1750

  Fly  1760 IQKPTHGNIGLGHEFKHMQRYHPSDFF---TKKVY---YIHDHSDTLEDTILMSVYLTQGNI--- 1815
            ...|.||.|.:|.  :::....|  :|   |..|:   |:||.|::|.|....:|:....|.   
Mouse  1751 TALPHHGTIMVGE--RNITTGRP--YFSQHTVNVFGAAYLHDDSESLADNFTFAVWPNPKNKSTS 1811

  Fly  1816 -----FLCNLTIPVSINPINDQPFHLVTHLPQMTVVEGENRTITRNDLLTEDADTPPEEIIYDVM 1875
                 ||..: ..::|.|:||||..|.|...::||::|:...:....|..||.|:||.||.|:::
Mouse  1812 KPEAGFLEEM-FNITITPVNDQPPELKTKGLRLTVLQGDRLVVGPEILNVEDIDSPPNEIQYEII 1875

  Fly  1876 SGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQSTTFCFTVSDGQSNPAYEI 1940
            ..|..|.|      ....|..|.::.||||||||.::.::....|.|..|.|:|:||:..|.|::
Mouse  1876 RHPNNGFL------AMAHDPDATAHHFTQADINNAQVWFIQDRSPSSGVFYFSVTDGKHRPLYKL 1934

  Fly  1941 FTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLDHIGVSTNVHMERLSYNVTNSPLFGIIVYKHQP 2005
            |.:.:..|.:....: ..:.:.||..|.|:...|:...||....::.|.:|.....|.::.::|.
Mouse  1935 FHLDVTPISITLVNL-TDLLLPQGQNTVPITNTHLSAVTNGRSLQIIYRMTQPLQSGHLLIENQV 1998

  Fly  2006 TLRFTQQQLETSQISYMQTDLNRSNDSFQVSAYVPGTNYVAQVDVVMEVEPVIQINDIVMKEAES 2070
            ...|.|:.|::.::||..|:|..|.|..:||.:....|...|. :.:.|:|::.:          
Mouse  1999 VNSFGQEDLDSGRLSYHMTNLTASEDQLRVSLFTTECNLTEQT-LNIRVQPLLWV---------- 2052

  Fly  2071 SGGKIKLITSLDNDNPLSLKL-----------NKFN--PKFVITRMPSTGQ-IRKIIRSTGLTTD 2121
                   |.:|...|.::.:|           |:.|  |.|.:.:....|: :|:.:.|..:...
Mouse  2053 -------IANLKVTNRVAHQLRTEDLDATELANRTNSDPMFEVIQPLVHGRLVRRAVDSPVMEEI 2110

  Fly  2122 GQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQPAQ-------------- 2172
            .|       |:..::..|.:...||.::..|...:|||.:.|....||||.              
Mouse  2111 TQ-------FTQTDINQGQLVLEPHANLTGTHTLNDSFTFLLSADHVQPAAGYLAFTIVPPDPLP 2168

  Fly  2173 ------------------ATVSIEYRSRV---EETET---------------------------- 2188
                              |:||.:.:.|.   ::|||                            
Mouse  2169 LQTFTPDVPLFVTGETLVASVSSQKKLRASIKKQTETPGNLTQGRWQGTDSWGQLSGKEPNIDAK 2233

  Fly  2189 ------------VHLG---SAG-----LSINYLAIGCAIFIVLICLLIVLLILKIRKLRKHKADI 2233
                        ..:|   |.|     :|.:.|.:...:..|.:.||:.::.|.:..|.:     
Mouse  2234 VSPTRVIWPYAATKVGESLSGGAMQPEMSRHPLVVIIPLAAVFLLLLVTVVALCVWLLSR----- 2293

  Fly  2234 SKDQPPALPCP-PDLTSVSPQHHLHHHHGHHYASSEAD---SVPATGNSTPLPGFSNIPHCKIIP 2294
            .:|:|..|..| .:|.|.|             ..|.|:   ::| |...|||...|..|  .:..
Mouse  2294 KEDKPKPLTQPKTNLKSPS-------------TGSRAERSGAIP-TVTVTPLIRSSLAP--SLFQ 2342

  Fly  2295 VESYKHEYP-DYDPDEEETDDQCDPQQMMLPQRYNPYHMEHDAW-SSSCDMANDFAGYASVPQSI 2357
            .:||....| ..:|.|     :|.|               .||| :...|||.            
Mouse  2343 TQSYDRPAPLGAEPVE-----KCAP---------------WDAWVNLDPDMAK------------ 2375

  Fly  2358 SGSVSSPPSAPPTNPLLRRNQYWV 2381
                    ....|||.|:.|||||
Mouse  2376 --------LCRQTNPALKHNQYWV 2391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058 46/146 (32%)
LamG 211..365 CDD:238058 45/163 (28%)
Cadherin_3 507..664 CDD:292802 45/175 (26%)
Cadherin_3 631..776 CDD:292802 45/152 (30%)
Cadherin_3 747..892 CDD:292802 34/152 (22%)
Cadherin_3 861..1005 CDD:292802 40/149 (27%)
Cadherin_3 979..1121 CDD:292802 45/157 (29%)
Cadherin_3 1093..1242 CDD:292802 34/149 (23%)
Cadherin_3 <1264..1361 CDD:292802 30/101 (30%)
Cadherin_3 1330..1464 CDD:292802 40/136 (29%)
Cadherin_3 1436..1578 CDD:292802 54/143 (38%)
Cadherin_3 1789..1932 CDD:292802 49/153 (32%)
Cadherin_3 2009..2163 CDD:292802 35/167 (21%)
Cspg4bNP_001365627.1 LamG 26..175 CDD:238058 46/146 (32%)
LamG 213..369 CDD:238058 43/160 (27%)
Cadherin_3 429..518 CDD:406568 31/96 (32%)
Cadherin_3 535..644 CDD:406568 31/127 (24%)
Cadherin_3 <668..759 CDD:406568 30/91 (33%)
Cadherin_3 878..987 CDD:406568 32/114 (28%)
Cadherin_3 1005..1114 CDD:406568 33/111 (30%)
Cadherin_3 1132..1218 CDD:406568 18/102 (18%)
Cadherin_3 <1250..1339 CDD:406568 28/89 (31%)
Cadherin_3 <1364..1444 CDD:406568 25/79 (32%)
Cadherin_3 1455..1562 CDD:406568 40/107 (37%)
Cadherin_3 1686..1802 CDD:406568 35/120 (29%)
Cadherin_3 1821..1926 CDD:406568 38/111 (34%)
Cadherin_3 2036..2146 CDD:406568 24/134 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850060
Domainoid 1 1.000 80 1.000 Domainoid score I8605
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 676 1.000 Inparanoid score I723
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46545
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003479
OrthoInspector 1 1.000 - - otm43946
orthoMCL 1 0.900 - - OOG6_106870
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4086
SonicParanoid 1 1.000 - - X2369
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.690

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