DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kon and Frem3

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001161370.1 Gene:Frem3 / 333315 MGIID:2685641 Length:2127 Species:Mus musculus


Alignment Length:2110 Identity:421/2110 - (19%)
Similarity:740/2110 - (35%) Gaps:642/2110 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   440 LLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEKAIFVPC 504
            |:..|..|:.:|.:.:|:| ..|:::.::|    .:|..: .|:..|:    ||.:.....| ||
Mouse    62 LIANSGFQVPQGRSVWLNP-LRDLVIRVQR----GDQCKV-TVLDFPR----LQGALSPHQF-PC 115

  Fly   505 RTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHK----IPENILGKHRFLLHANITPIND 565
                  |....::||.|.|..: :....:.:|:..|...    :|        |.|..|:.    
Mouse   116 ------DFGAQQVKYTHFGSPS-STRTRIQLQVRYDAGNSTLVLP--------FTLQVNVV---- 161

  Fly   566 PPQLRLHSH----KILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILP-TQSPQETFGCFI--V 623
            .|:|:|.:.    |:.:|: |....:|..:.|.    :.......|:|| ...|...:|..:  .
Mouse   162 FPKLQLVARNRPLKVFKVL-GCSHAIDRRVLNF----ASRSRCRLTVLPHPGGPLPKYGLLVDTA 221

  Fly   624 GG-------ATTSAFSQAEVNVGKVSYLYNSTTAES--------FSYELQLQVSDGIETSETV-- 671
            |.       |...||.||.|.       |..||..|        ...||....|.|..:.|.:  
Mouse   222 GNPLSRGHLADCEAFIQAGVR-------YQHTTTPSSPSRDYVPMLVELLGPESQGTRSVEVLAQ 279

  Fly   672 -YLPVSVHPLELRLVNNTG---------LIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAP 726
             |..:.|. ::.| ..:|.         ::.:.:|.|...|.::....::..|..|:.::|:..|
Mouse   280 EYFQIQVR-IQKR-ARSTAPIPSLAALMIVEVEQSLLTALTPDVLAAEDSESDPDDLVFNILNVP 342

  Fly   727 Q-----HGVLQRLRQIDGSWVNVD--------WFSDSQLLLGHIRY-----LHSSDFPWQDEFKF 773
            :     ||.       .|..||.|        :|:..:|....|.|     ....|..:|.:.:.
Mouse   343 EAPPGHHGG-------QGYVVNTDDPLGLPVSFFTQKELRELKIAYRPPTGSSEGDHVFQLKLQV 400

  Fly   774 IASFGFVTTQTFDFRITFTRLR----ITSTRPSQISINGSREILLTSDVLSYETTPIGSFARSVI 834
            :...| .|::.|.|.:....:.    |.|.|...:...|....|  ||.||::.:...: ::.:.
Mouse   401 VDEDG-DTSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPL--SDALSFQVSDKDN-SKEIK 461

  Fly   835 YKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRRIRYQTHHTSYSSFSDHL------------ 887
            ....:..::|.:.|.|:....|   :||..|:...|:.||  |....|:||::            
Mouse   462 IVAVRGLQHGQLVVHGAPAGCK---NFTLADLSAGRVVYQ--HDGSDSYSDNIILKMEGEHHRVD 521

  Fly   888 -EFVVSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGERALIT--------------- 936
             .|.:::...||.|.||..|          :|      |.|.||:...|:               
Mouse   522 FLFPITIVPVDDAAPVLTAN----------MG------LSVTEGQVVQISPFVLCATDIDSEDSA 570

  Fly   937 ---------------KNHFGIRFNIYESLQFQVSL-----SPEHGVICK---YDEQTGL-TTPVE 977
                           :.|..:....|.|.|...::     .|...::..   |.|:.|| .|.|.
Mouse   571 ILFVLEDEHLEGKEEETHEDLAPGSYSSSQHPGNMLLRQAEPPSSLLYSDWHYVEKEGLYETVVT 635

  Fly   978 MFTLEQLFRNDIYYCHDDTESTRDTFELLILSGDETDLQFVSNME---VHIKLVNDNEPYRTAIE 1039
            .:....:....:::.|....|......|.....|:.|...:||..   :.|:..:.::| :.:.|
Mouse   636 EWLQRDIMEGRLFFSHPGPHSPSPVAHLAFHVQDDQDPPNLSNQHFFTISIQPADTSQP-QLSPE 699

  Fly  1040 RVFHVVRNGIRTLNPTVLQYLD-ADVNTNHTDIHYIHVSSTNGAFYKSGHYIDS----------- 1092
            ....:...|.: |.|...:||. .|.|::..::.|..::....|  .|.|.:.:           
Mouse   700 TTLEMTVQGYQ-LTPFQQKYLQYTDQNSDEQNLWYTLLTRPTDA--DSNHQVQAGEIVLTDSPGR 761

  Fly  1093 ----FTQDDIANRRIMFQHTGADSGTA------SFIVTDRE-HEVNGLLEIRASDPFVSMMATNA 1146
                |||..:.:::|.::....:.|..      ::.|.|.. :.|:|...:     |:..:....
Mouse   762 PIVHFTQTQVNHQKIAYRPPQRNLGIVPRVVQFTYKVEDTAGNSVSGTFTV-----FLQPLNNQP 821

  Fly  1147 SIVQEGKFVVLKNKDFIL---ETNL---DMKLDEIYYEVIKPPSYGILMYLSR-ANEGE------ 1198
            ..|....|.||:...|||   |.|:   |...|:|::.::..|.:|.|.|..: ...||      
Mouse   822 PKVINRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESFMLAD 886

  Fly  1199 --NGTTIYK-------------------------------------------------ATNYTSL 1212
              ||:..|:                                                 ||:.|.|
Mouse   887 VINGSISYQNSRDQTDSDVIYLEVSDGVHHIPITVQVSVQPTVADRSPGISITGTPVLATSLTVL 951

  Fly  1213 SNFTH---LDIERERLVYWNTEIASM-----DKVRYRVHIKN------ITAE------------- 1250
            .|...   :|:...|.   ||....:     ||.:..:.:.|      :|.|             
Mouse   952 ENAASEITMDVTHGRK---NTNDLMLSFIVEDKPKLGMILVNGWPAEQVTQEDLLGGAVSYVHTS 1013

  Fly  1251 GEVMF-RIYPS--------AYWEPLQVKQNHTLYVEEST--------SVLI---------SRDVL 1289
            ||:.| |::.:        ||...::......:.||.:.        .||:         .:::|
Mouse  1014 GEIGFQRVHDTFSFILSKDAYHRAMRDNILERVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLL 1078

  Fly  1290 EVVHPNI-----SPGDITFLVTSSPMHGYLEMQSMSFDDEYN-----CKVFDQSSVNTEKMFYIQ 1344
            ...|.||     |..:|...:|..|..||||..:.:...|.:     ...|....|....:.|:|
Mouse  1079 TPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLAPAPGSEVSRAGNPISAFFVKDVRVGCINYVQ 1143

  Fly  1345 A---GVNQSTDYFVFDVTNGITWLRQLMIKIVIIP---EKLYMHSNIISVVEGKTVQLNPTDIQP 1403
            :   |:....|.|.|..::||.:..::::.:.|:|   |:..:.:....|:||.:..::.:.:..
Mouse  1144 SIHKGIEPGADQFTFYCSDGINFSPKVLLPLTILPTNDEQPQLFTREFVVLEGMSRVIDTSLVNG 1208

  Fly  1404 YSEYYRGKILEYIVTITPSSGHV---LAGNSK-VKRFTQKQL-EQGSIQYVHNGSENATDSITLV 1463
            ....:....|.:.:|:.|..|.:   ||..|| :..||.::: |..||.|.|:.||:..||.. |
Mouse  1209 VDADFPSDKLHFRLTVFPQHGQITQQLATGSKPIHSFTLQEIQEPSSIAYEHDDSESTEDSFE-V 1272

  Fly  1464 AMARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVV- 1527
            .::..:.:....:..||:.|:||.|.:..|.||::..|...:|.|..|.|.|.|:..::|:||: 
Mouse  1273 WLSDGRHTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLH 1337

  Fly  1528 NHIYGGYLARKSAPHQKIEH-------FTQAQINLEEIYFMHDSNSRRNELSFVVTDGL------ 1579
            :....|.|.|...|....:|       |||.:|:...|:::|.......:|.|.||||:      
Mouse  1338 SEPQQGLLQRLRKPGGDAKHNLTVGMNFTQDEIDRGLIHYIHTGQGEAVDLKFDVTDGVNTLRDR 1402

  Fly  1580 -FNTTTQMLNIEIKPI----EILAEHNENLHVFPLTKKQILRDYLHFKCSDEEREIRYNITVPPS 1639
             |..|....|..:..|    ..|.|.|.    ..||.:.:....:|    ....::.|:||..||
Mouse  1403 YFYITIDNSNSAVPEIVSKRVTLTEGNR----MTLTTELLNTSDIH----SPGEQLLYSITRAPS 1459

  Fly  1640 LGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFN 1704
            .|.:  |..|.. .:.::.|||..:....|.|.|.       :||....|              :
Mouse  1460 TGHL--ESSDQP-GEPMASFTQLQLARNKISYVHI-------SNDKIKLD--------------H 1500

  Fly  1705 IEISVSSGGLLRFLPVNKLNVDEGGSVPIKLDFSKILEYLKTKAGINNPELFIEAIQKPTHGNIG 1769
            .|:.|:.|           :..|          |:|.....|:.....|.|.|:|:.        
Mouse  1501 FELRVTGG-----------HHSE----------SRIFRIFVTEQDNKKPTLTIQALA-------- 1536

  Fly  1770 LGHEFKHMQRYHPSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCNLTIPVSINPINDQPF 1834
                   :||                                                       
Mouse  1537 -------LQR------------------------------------------------------- 1539

  Fly  1835 HLVTHLPQMTVVEGENRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFS 1899
                         |:|..:|.:.|..||.|||.:.|::.:...|..|  |.:.|..||      .
Mouse  1540 -------------GDNIVVTPSQLTVEDEDTPADFILFTITQIPIHG--RILYNGSRP------V 1583

  Fly  1900 NQFTQADINNDRIIYVHFGMPQS-TTFCFTVSDGQSNPAYEIFTIKIDS-------IHLQPSAMQ 1956
            ..||:.|:....|:|.|.|...| .:|.|||:||.....|......:::       |.:.|...:
Mouse  1584 TTFTKKDLTKSLILYCHDGSETSKDSFSFTVTDGIHTGFYVFPDTSLETHVPQTVWIQISPFDDR 1648

  Fly  1957 AP-VKVQQGATTAPMRLDHIG----VSTNVHMER---------LSYNVTNSPLFGIIV---YKHQ 2004
            .| :.:.:|||.  ::|.|.|    :.||.:::.         |:|.||..|..|.||   ..::
Mouse  1649 LPQMGINRGATA--LKLLHTGHLGFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNE 1711

  Fly  2005 PTLRFTQQQLETSQISYMQTDLNR-----SNDSFQVSAYVPGTNYVAQVDVVMEVEPVIQINDIV 2064
            .|..|||..::..::.|:   ||:     :.|:|..|                            
Mouse  1712 NTHMFTQADIDEMRVYYI---LNKGRGRATRDTFYFS---------------------------- 1745

  Fly  2065 MKEAESSGGK-------------IKLITS---LDNDNPLSLKLNKFNPKFVITRMPSTGQIRKII 2113
               .|:.|||             |.|...   :|.|:|..        :..:||       |..:
Mouse  1746 ---VETRGGKQLRNQPFHLNWAWISLEKEYYIVDEDSPFF--------EVTLTR-------RGYL 1792

  Fly  2114 RSTGLTTDG-QSDRSTNIFSYKELRSGVVYFVPHES--------VEETEADHDSFDYQLLIKTVQ 2169
            ..|.:.:.| :.|.:.....:|.....:|.|.|.:|        :.:|:.: .|..:|:::.  :
Mouse  1793 GGTSVVSIGTKGDTAEENKDFKGKAPMLVQFSPGQSTATWRVGLIPDTKYE-TSETFQIILS--E 1854

  Fly  2170 PAQATVSIEYRSRV-----EETETVHLGSA 2194
            |..|.:.....:.|     |:..||::..|
Mouse  1855 PGAAALEFPEMATVEIVDPEDESTVYIPEA 1884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058
Cadherin_3 507..664 CDD:292802 38/182 (21%)
Cadherin_3 631..776 CDD:292802 36/182 (20%)
Cadherin_3 747..892 CDD:292802 34/166 (20%)
Cadherin_3 861..1005 CDD:292802 36/195 (18%)
Cadherin_3 979..1121 CDD:292802 27/166 (16%)
Cadherin_3 1093..1242 CDD:292802 42/227 (19%)
Cadherin_3 <1264..1361 CDD:292802 25/126 (20%)
Cadherin_3 1330..1464 CDD:292802 35/144 (24%)
Cadherin_3 1436..1578 CDD:292802 46/150 (31%)
Cadherin_3 1789..1932 CDD:292802 28/143 (20%)
Cadherin_3 2009..2163 CDD:292802 31/183 (17%)
Frem3NP_001161370.1 CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 298..399 19/107 (18%)
Cadherin_3 <305..396 CDD:292802 18/97 (19%)
Cadherin_3 369..513 CDD:292802 33/152 (22%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 424..514 23/97 (24%)
Cadherin_3 485..>576 CDD:292802 23/108 (21%)
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 535..668 24/148 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..601 3/18 (17%)
Cadherin_3 639..778 CDD:292802 25/142 (18%)
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 693..799 18/109 (17%)
Cadherin_3 766..913 CDD:292802 31/151 (21%)
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 820..911 21/90 (23%)
Cadherin_3 882..1030 CDD:292802 21/150 (14%)
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 939..1030 18/93 (19%)
Cadherin_3 998..1163 CDD:292802 33/164 (20%)
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1059..1161 23/101 (23%)
Cadherin_3 1129..1277 CDD:292802 36/148 (24%)
Cadherin_3 1245..1395 CDD:292802 46/150 (31%)
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1296..1395 29/98 (30%)
Cadherin_3 1365..1508 CDD:292802 41/174 (24%)
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1414..1506 25/123 (20%)
Cadherin_3 1476..1617 CDD:292802 50/273 (18%)
Cadherin_3 1586..1746 CDD:292802 44/195 (23%)
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1649..1747 27/133 (20%)
Calx-beta 1766..1853 CDD:295344 19/102 (19%)
Calx-beta 1877..1977 CDD:295344 3/8 (38%)
Calx-beta 2007..2097 CDD:295344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I12109
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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