DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kon and Frem1

DIOPT Version :10

Sequence 1:NP_609881.3 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_808531.2 Gene:Frem1 / 329872 MGIID:2670972 Length:2191 Species:Mus musculus


Alignment Length:1948 Identity:398/1948 - (20%)
Similarity:691/1948 - (35%) Gaps:497/1948 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 IIFHVVHQPKYG---QLLQYSAEKAIFVPCRTFNLVDLATDKLKY-VHNGQENFNDHATLDMQIF 538
            ::|::...|..|   .||.::.      |..:|...||:..::.| ..|.......|.|::::::
Mouse   338 LVFNITKAPLQGYVTHLLDHTR------PISSFTWKDLSDMQVAYQPPNSSHPERRHYTMELEVY 396

  Fly   539 GDVHKIPENILGKHRFLLHANI-TPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPG 602
            ....:....|      .:|.:| |...:.|::..::.  |.::||..|.:..:.|.|.|.|....
Mouse   397 DFFFERSAPI------TVHISIRTADTNAPRVSWNTG--LNLLEGQSRAITWEQFQIVDNDDIGA 453

  Fly   603 NLIYTILPTQSPQETFGCFIVGGATTSAFSQAEVNVGKVSYLY-NSTTAESFSYELQLQVSDGIE 666
            ..:.||...|     .|...|.......|:..::..|.|.|.: :|.|.:.|   :..::.||..
Mouse   454 VQLVTIGGLQ-----HGRLTVREGKGFLFTVTDLQAGVVRYHHDDSDTTKDF---VAFRIFDGHH 510

  Fly   667 TSETVYLPVSVHPLELR---LVNNTGL-------IMIHKSSLPISTANLSIGTNAVDDHIDIRYD 721
            :|...: |:::.|.:..   |:.|..:       |:|..|.|..|..:.|      ||:  |.::
Mouse   511 SSHHKF-PINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSS------DDY--IFFN 566

  Fly   722 IVKAPQHGVLQRL---RQIDGSWVNVDWFSDSQLLLGHIRYLHSSDFPWQDEFKFI-----ASFG 778
            |.|.||.|.:.:.   |.|.   ..|..|....|..|.|.|.|.....::|.|:|:     ....
Mouse   567 ITKFPQAGEIMKKPGPRLIG---YPVPGFLQRDLFSGIIYYRHFGGEIFEDSFEFVLWDSHEPPN 628

  Fly   779 FVTTQTFDFRITFTRLRITSTRPSQISINGSREILLTSDVLSYET------TPIGSFARSVIYKI 837
            ....|.....||....::....|..     ||.:::....::|.|      ..:.|....:||.:
Mouse   629 LSVPQVVTIHITPVDDQLPKEAPGI-----SRHLVVKETEVAYITKKHLHFLDMESRDGELIYTV 688

  Fly   838 TKPTRY---------GGIYVEGS------RKAAKKLDSFTQQDIEKRRIRYQTHHTSYSSFSD-- 885
            |:|..:         |.:::..|      ...|..|.||||..|    :.....||..|.|:.  
Mouse   689 TRPPCFSFSHRHLDAGKLFMVDSIPKLTKNPTAPGLSSFTQGLI----LISANQHTCSSQFASQH 749

  Fly   886 ---------------------HLEFVVSVAE---------CDDVAGVLEINYRPPDELINKLGYQ 920
                                 |::|.|||:.         |.::. ||.::.:.|:...|     
Mouse   750 AVNHMKVAYMPPMQDIGPSPRHVQFTVSVSNQHGGALHGICFNIT-VLPVDNQVPEVFTN----- 808

  Fly   921 NHEPLQVQEGERALITKNHFGIRFNIYESLQFQVSLS----PEHGVICKYDEQTGL-TTPVEMFT 980
               .|:|.||.:..|:..|  |..:..::....:|||    |.||.:    |..|. ..|...|:
Mouse   809 ---TLRVVEGGQCTISTEH--ILVSDVDTPLDSISLSLKERPLHGGV----ELDGFPLNPRGTFS 864

  Fly   981 LEQLFRNDIYYCHDDTESTRDTFELLILSGDETDLQFVSNMEVHIKLVNDNEPYRTA-IERVFHV 1044
            ...|....::|.||.:|..:|...|.:..|..: ..||.::||.  .|||..|...| :..:.|.
Mouse   865 WRDLNTLKVWYQHDGSEVLQDEIFLEVTDGTNS-AAFVLHIEVF--PVNDEPPILKADLIPMMHC 926

  Fly  1045 VRNGIRTLNPTVLQYLDADVNTNHTDIHYIHV---SSTNGAFYKSGHYIDSFTQDDIANRRIMFQ 1106
            ...|..|:.|..:...|||.:    |:..:.:   ...:|...|:|.::|.|:|.|:.:..:.::
Mouse   927 SEGGEVTITPEYISATDADSD----DLELLFLIAREPQHGVVRKAGLHVDRFSQGDVISGAVTYK 987

  Fly  1107 HTGADSG------TASFIVTDREHEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILE 1165
            |||.:.|      |...:|:|.|           :||.:     |..........|..:|.|   
Mouse   988 HTGGEIGLEPCSDTVVLVVSDGE-----------ADPLM-----NGCCYDGPDSSVPLHKSF--- 1033

  Fly  1166 TNLDMKLDEIYYEVIKPPSYGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNT 1230
                             |:|.:            ..|::...|                      
Mouse  1034 -----------------PTYQL------------NITVHPVDN---------------------- 1047

  Fly  1231 EIASMDKVRYRVHIKNITAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPN 1295
                                             :|..:.....|.|:|..|..::...|.||..:
Mouse  1048 ---------------------------------QPPSIIIGRMLTVDEGFSAALTTHHLTVVDWD 1079

  Fly  1296 ISPGDITFLVTSSPMHGYLE--MQSMSFDDEYNCKV----FDQSSVNTEKMFYIQA---GVNQST 1351
            .:|.|:.|::.|.|..||||  :.|..| ::.|..:    |..:.:....:.|:|:   .|..:.
Mouse  1080 TAPDDLKFMLASQPQFGYLENALPSAGF-EKSNIGIRIASFQWTDMKASHINYVQSRHLRVEPTA 1143

  Fly  1352 DYFVFDVTNGITWLRQLMIKIVIIP---EKLYMHSNIISVVEGKTVQLNPTDIQPYSEYYRGKIL 1413
            |.|....|:|.....:....::|.|   |...:....|:|.||..|:|:.:.|...........|
Mouse  1144 DQFTVYATDGKHRSLETTFHVIINPTNDEAPDLAVQNITVYEGHMVELDSSIISATDRDIPKDPL 1208

  Fly  1414 EYIVTITPSSGHVL-AGNSK-----------VKRFTQKQLEQG-SIQYVHNGSENATDSITLVAM 1465
            .:.:.:.|..|.:: |..||           :..|:...|:.| .:.|.|:.||::.|:. ::.:
Mouse  1209 LFSIALKPQHGLLVDAAISKDSHQIKQLQHEIHSFSVDLLKNGMKLVYAHDDSESSADNF-VIQL 1272

  Fly  1466 ARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHI 1530
            :..|..:...:...:..||||.|.:.....:.:..|...|:.:..|.|.|.|:|.|.:.:|...:
Mouse  1273 SDGKHKILKTISVNITPVNDETPTLSKKAEISMAVGDTRVLSSAVLSATDKDSPREKIHYVFERL 1337

  Fly  1531 -YGGYL----ARKSAPHQKIEHFTQAQINLEEIYFMH-------------------DSNSRRNEL 1571
             ..|.|    .|...|.......||..::|..:.:.|                   |:.|...:.
Mouse  1338 PQNGQLQLKIGRDWVPLSTGMQCTQEDVDLNLLRYTHAGKTDSQDGDSFTFYLWDEDNRSPAFDC 1402

  Fly  1572 SFVVTDGLFNTTTQM----LNIEIKPIEILAEHNENLHVFPLTKKQILRDYLHFKCSDEEREIRY 1632
            ..::.|        |    :.|..||: ::.:.:..|    ||...:|.    ...:|:..|:.|
Mouse  1403 HIIIED--------MGKGDIVIHAKPL-VVVKGDRGL----LTTATLLA----VDGADKPEELLY 1450

  Fly  1633 NITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEH---TAVIMEFRTNDSFYFDVVAER 1694
            .||.||..|::  |::.:... .::.|:|.|:....:.|.|   |||     ..|||.|.:    
Mouse  1451 LITSPPRHGQV--EYVHSPGV-PIASFSQMDIAGQTVCYIHKSRTAV-----PTDSFRFTI---- 1503

  Fly  1695 SDRLLNQKFNIEISVSS-GGLLRFLPVNK-LNVDEGGSVPIKLDFSKILEYLKTKAGINNPE-LF 1756
            |:.|..|:...||::.: ...|..|..|| |.:.||....:..|      :|:.......|| |.
Mouse  1504 SNGLQTQRGVFEITLQTVDSALPVLTKNKRLRLAEGAMGLLSAD------HLQLTDPDTPPENLT 1562

  Fly  1757 IEAIQKPTHGNIGL-GHEFKHMQRYHPSDFFTKKVYYIHDHSDTLED--TILMSVYLTQGNIFLC 1818
            ....|.|.||.:.| |...:|  .:...|..:..|.|.|......||  |.|.:....||.:   
Mouse  1563 FFLAQLPRHGYLFLRGKALQH--NFTQRDVDSGGVAYQHSGGGAREDYFTFLATDRKNQGFV--- 1622

  Fly  1819 NLTIPVSINPIN--------DQPFHLVTHLPQMTVVEGENRT------ITRNDLLTEDADTPPEE 1869
             :...|...|:.        |:....:|||...|.| |..:.      ||...|...|.||..::
Mouse  1623 -VDGKVQKEPVRFTIQVDQLDKAAPRITHLHSPTQV-GLLKNGCYGIYITSRVLKASDPDTEDDQ 1685

  Fly  1870 IIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQSTTFCFTVSDGQS 1934
            ||:.::.||..|.|...|...      ....:|:|.|:::..|:|:                  .
Mouse  1686 IIFKILRGPLYGRLENTTTGE------FIHERFSQKDLSHKTILYI------------------I 1726

  Fly  1935 NPAYEIFTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLD-----------HIGVSTNVHMERLSY 1988
            ||:.::.:..::...:.|:          |.|..|..||           ...|..||.:  |..
Mouse  1727 NPSLQVTSDILEFQAMDPT----------GNTATPQSLDLRWSYIEWAQTAYEVCENVGL--LPL 1779

  Fly  1989 NVT------NSPLFGIIVYKHQPTLRFTQQQLETSQISYMQTDLNRSNDSFQVSAYVPGTNYVAQ 2047
            .||      :|...|:.|.:...|:   .:....:....:|.|...|...:.::....|   :.:
Mouse  1780 EVTRRGYPMDSAFVGVEVNQVSATV---GKDFTVTPSKLLQFDPGMSTKMWNIAITYDG---LEE 1838

  Fly  2048 VDVVMEVEPVIQINDIV-------MKEAESSGGKIKLITSLDNDNPLSLKLNKFNPKFVITRMPS 2105
            .|.|.||.....:|.::       :|..:|.||:.....|.:.....:.....::|      :||
Mouse  1839 DDEVFEVILNSPVNAVLGTQTKAAVKILDSKGGRCHPSNSFNQSKHSTWGKGPWHP------LPS 1897

  Fly  2106 TGQIRKIIRSTGLTTDGQ------------------------SDRST-------NIFSYKELRSG 2139
                    .|:.|||.|.                        :.|.|       ::......|:|
Mouse  1898 --------GSSSLTTSGSPLLERPPPSFTSGDALQGFGLTDLTQRKTMTQGNGKSVLPSSVCRNG 1954

  Fly  2140 VVYFVPHESVEETEADHDSFD---YQLLIKTVQPAQATVSI---EYRSRVEETETVHLGSAGL 2196
            ......:..:...:.:.|.|.   .:..|..|...|.|:.:   ....:||.|..:|....||
Mouse  1955 TDTIYNYHGIVSLKLEGDRFSAHKRKAKISIVSQPQRTIKVAELPLADKVESTTDLHFLRQGL 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_609881.3 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058
Cadherin_3 <445..535 CDD:465048 13/60 (22%)
Cadherin_3 552..664 CDD:465048 24/113 (21%)
Cadherin_3 667..773 CDD:465048 30/118 (25%)
Cadherin_3 781..892 CDD:465048 28/154 (18%)
Cadherin_3 921..1005 CDD:465048 23/88 (26%)
Cadherin_3 1025..1121 CDD:465048 26/105 (25%)
Cadherin_3 <1149..1230 CDD:465048 7/80 (9%)
Cadherin_3 1264..1361 CDD:465048 27/105 (26%)
Cadherin_3 1369..1464 CDD:465048 24/110 (22%)
Cadherin_3 1470..1578 CDD:465048 24/131 (18%)
Cadherin_3 1821..1932 CDD:465048 27/124 (22%)
Frem1NP_808531.2 Frem_N 35..267 CDD:466034
Cell attachment site 205..207
CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 300..394 13/61 (21%)
Cadherin_3 <319..377 CDD:465048 9/44 (20%)
Cadherin_3 402..508 CDD:465048 25/121 (21%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 419..506 21/96 (22%)
Cadherin_3 510..622 CDD:465048 31/123 (25%)
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 527..621 28/104 (27%)
Cadherin_3 630..706 CDD:465048 14/80 (18%)
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 648..779 27/139 (19%)
Cadherin_3 791..894 CDD:465048 28/117 (24%)
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 801..892 26/104 (25%)
Cadherin_3 896..1009 CDD:465048 30/119 (25%)
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 912..1007 22/98 (22%)
Cadherin_3 1038..1153 CDD:465048 29/182 (16%)
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1049..1151 26/102 (25%)
Cadherin_3 1156..1275 CDD:465048 24/119 (20%)
CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1172..1273 22/101 (22%)
Cadherin_3 1277..1392 CDD:465048 22/114 (19%)
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1294..1391 18/96 (19%)
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1412..1504 28/112 (25%)
Cadherin_3 1414..1506 CDD:465048 29/112 (26%)
Cadherin_3 1508..1615 CDD:465048 30/114 (26%)
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1525..1614 27/96 (28%)
Cadherin_3 1628..1743 CDD:465048 28/139 (20%)
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1650..1742 25/116 (22%)
Calx-beta 1765..1847 CDD:413355 18/89 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1874..1921 9/60 (15%)
CLECT 2065..2187 CDD:214480
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.