DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kon and Frem3

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001178628.1 Gene:Frem3 / 307767 RGDID:1562701 Length:2124 Species:Rattus norvegicus


Alignment Length:1922 Identity:399/1922 - (20%)
Similarity:683/1922 - (35%) Gaps:517/1922 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 HGVDGFICYCDQSYCIKADFQGPFKIFTETS-PELELLYVSPMQLLEGGTAF------------L 456
            ||..|.:...|....:      |...||:.. .||::.|..|....||...|            .
  Rat   350 HGRQGSVVNTDDPLGL------PVSFFTQKELRELKIAYRPPTGSSEGDLIFQLVLQVEDEDGDT 408

  Fly   457 SPHFIDIIL----------------------------DLRRYP-SLNEQSIIFHVVHQPKYGQLL 492
            |..|:.:::                            |.:.:. |.|.:.|....|...::|||:
  Rat   409 SEPFVFMVVVKSLNALAPAARYSAGLAVYEGQARPLSDAQNFQVSDNSKEIRIAAVRGLQHGQLV 473

  Fly   493 QYSAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHR--FL 555
            ...|.    |.|:.|...||:..::.|.|:|.::::|:..|:|:.            |.|:  ||
  Rat   474 VRGAP----VECKCFTPADLSAGRVVYQHDGSDSYSDNVILEMED------------GHHQVDFL 522

  Fly   556 LHANITPINDPPQLRLHSHKILRVIEGIERVLDVDLFNI--DDPDSEPGNLIYTILPTQSPQ--- 615
            ....|.|::|...: |.::..|.|.||  :.:.:..|.:  .|.|||...::: :|..|.|:   
  Rat   523 FPITIVPVDDEAPV-LTTNTGLSVTEG--QAIPISPFVLCATDIDSEDSAILF-VLEDQHPEGKE 583

  Fly   616 ---------------ETFGCFIVGGA----------------------TTSAFSQAEVNVGKVSY 643
                           :..|..::..|                      ..:.:.|.::..|::.:
  Rat   584 KKRGEALTPGFYSSNQYTGKMLLRQAEAPSSLLRSDWYYVEKEGLYEKAVTEWLQRDITEGRLFF 648

  Fly   644 LYNSTTAESFSYELQLQVSDGIE---TSETVYLPVSVHPLEL---RLVNNTGLIMIHK--SSLPI 700
            .|....:.|....|..:|.|..:   .|....|.:|:.|.|.   :|...|.|.|..:  ...|.
  Rat   649 FYLGPHSPSTVARLAFRVQDDHDPPNLSNQHLLTISIQPAEKQSPQLSPETTLEMTVQGYQLTPF 713

  Fly   701 STANLS-IGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLHSSD 764
            ....|. ||.|:.|.::.  |.::..|                 .|..|:.|:..|.|....|.:
  Rat   714 QKKFLQYIGQNSDDQNLS--YTLLTGP-----------------TDMDSNHQVPAGEIVLTDSPN 759

  Fly   765 FP------WQDEFKFIA------SFGFV-TTQTFDFRI----------TFTR-LRITSTRPSQIS 805
            .|      .|...:.||      :.|.| ....|.:::          |||. |:..:::|.::.
  Rat   760 RPIVHFTQAQVNHQKIAYRPPPRNLGIVPRVVQFTYKVEDIAGSSVPGTFTLFLQPLNSQPPKVI 824

  Fly   806 INGSREILLTSDVLSYETTPIGSFARSV---IYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIE 867
            ..|...:...|.:|......:.....:|   .:.:....::|  :::..:|.....:||...|:.
  Rat   825 TRGFAVLEGHSFILGRGELNVSDPDTNVDQLFFVLVWGPQHG--HLQYFKKYMVPGESFMLADVV 887

  Fly   868 KRRIRYQTHHTSYSSFSDHLEFVVSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGER 932
            ...|.||  |:...:.||.:...||    |.|                     :|.|:.||....
  Rat   888 NGNISYQ--HSRDQTTSDVIYLEVS----DGV---------------------HHIPITVQVSVL 925

  Fly   933 ALITKNHFGIRF----------NIYESLQFQVSLSPEHG-------VICKYDEQTGLT----TPV 976
            ..:.|...|:.|          ::.|:...:|::...||       .|.:...:.|:.    .|.
  Rat   926 PTVAKRSPGVSFTDTRVLAISLDVLENAASEVTVGVTHGGKDLMLSFIVEDKPKLGIILVNGLPA 990

  Fly   977 EMFTLEQLFRNDIYYCHDDTE----STRDTFELLILS-------GDETDLQFVSNMEVHIKLVND 1030
            |..|.|.|....:.|.|...|    ...|.|..::.:       ||.|..:.:  :||.:..|::
  Rat   991 ERVTQEDLLGGAVSYAHTGGEIGFRGVCDVFSFILSTDARHPTVGDNTPERVL--VEVTVLPVDN 1053

  Fly  1031 NEPYRTAIERVFHVVRNGIRTLNPTVLQYLD-ADVNTNHTDIHYIHVSSTNGAFY---------- 1084
            ..| :.::...| ||..|.:  ||...|::: .||:|:..:|.....:.|:..:.          
  Rat  1054 TAP-KVSVGEPF-VVYEGEK--NPLTPQHVNIEDVDTSEDEILCTLTAQTSSGYLENLAPAPGSE 1114

  Fly  1085 --KSGHYIDSFTQDDIANRRIMFQ---HTGADSGT--ASFIVTDR-EHEVNGLLEIRASDPFVSM 1141
              ::|..|.:|...|:...||.:.   |.|.:.||  .:|..:|. ....|.||.:       ::
  Rat  1115 VSQAGSPISAFFIKDVRVGRINYVQSIHKGVEPGTDHFTFYCSDGVNFSPNVLLPL-------TI 1172

  Fly  1142 MATNAS----IVQEGKFVVLKNKDFILETNL------DMKLDEIYYEVIKPPSYG-ILMYLSRAN 1195
            :.||..    ..||  ||||:....:::|:|      |...:::::.:...|.:| ||..|    
  Rat  1173 LPTNDEQPELFTQE--FVVLEGMSRVIDTSLLNGVDADFPPEKLHFRLTVLPQHGRILQQL---- 1231

  Fly  1196 EGENGTTIYKATNYTSLSNFTHLDI-ERERLVYWNTEIAS--------MDKVRYRVHIK----NI 1247
                      ||....:.:||..:| |...:||.:.:..|        :...|:..|.|    .|
  Rat  1232 ----------ATGSKPIHSFTLQEIQEPSSIVYEHDDSQSTEDSFEVWLSDGRHSAHKKVPVVVI 1286

  Fly  1248 TAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHG 1312
            ..:.|..            |:..|..|.||...|.:|:..:|:...|:.....::|::.|....|
  Rat  1287 LVDDEAP------------QLAINDGLEVETGHSEIITNRMLKATDPDSDNKSLSFVLHSELQQG 1339

  Fly  1313 YLE-MQSMSFDDEYNCKV---FDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGITWLRQLMIKIV 1373
            .|: ::....|...|..|   |.|..::.:.:.|...|..::.|...||||:|:..||.....|.
  Rat  1340 LLQRLKKPGGDVRSNLTVGMNFTQDEIDRDLICYTHTGQGEAVDLLKFDVTDGVNPLRDHYFYIT 1404

  Fly  1374 ------IIPEKLYMHSNIISVVEGKTVQLNPTDIQPYSEYYRGKILEYIVTITPSSGHVLAGN-- 1430
                  ||||.:   |..:::.||..|.|........:.:..|:.|:|.:...|.:||:.:.:  
  Rat  1405 ISNSNSIIPEVV---SKRVTLTEGSRVTLTTELFNTSAIHSPGEQLQYCIKRAPRTGHLESSDQP 1466

  Fly  1431 -SKVKRFTQKQLEQGSIQYV-HNGSENATDSITLVAMARNKESVPFELEFAVVQVNDEEPMMVTN 1493
             ..:..|||..|....|.|| .:..|...|...| .:.....||.......|...::::|.:...
  Rat  1467 GEPIASFTQLHLASNKISYVCISKDERKMDHFEL-RVTGGHSSVSRVFRLFVTDQDNKKPTLTIQ 1530

  Fly  1494 TGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNH--IYGGYLARKSAPHQKIEHFTQAQINLE 1556
            | |.:..|...|:..:.|..:|.|||.:.:.|.:..  |:|..|...|.|   :..||:..:...
  Rat  1531 T-LVLQRGDSIVVTPSQLTVEDEDTPADFILFTITQVPIHGRILYNGSHP---VTTFTKKDLTEN 1591

  Fly  1557 EIYFMHD-SNSRRNELSFVVTDGL------FNTTT------QMLNIEIKP-IEILAEHNEN---- 1603
            .|.:.|| |.:.::..||.||||:      |..|.      ||:.|:|.| |:.|.:...|    
  Rat  1592 VILYRHDGSETTKDSFSFTVTDGIHAGFYVFPDTALETHVPQMVQIQISPLIDRLPQITINRGAR 1656

  Fly  1604 ----LHV----FPLTKKQILRDYLHFKCSD-EEREIRYNITVPPSLGRIVNEFIDNGFTKEVSEF 1659
                ||.    |.:|.|     ||.....| ..|.:.|.:|..|..|.|||..:.:   :....|
  Rat  1657 ALTILHTGHVGFLITSK-----YLQATHQDAPHRLLTYKVTSGPEHGYIVNAGLGD---ESTHTF 1713

  Fly  1660 TQNDVDNGHIFY----EHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFNI--------------- 1705
            ||.|:|...|:|    :|.:.     |.|:|||.|......:|.||.|::               
  Rat  1714 TQADIDEMQIYYILNKDHGSA-----TRDTFYFSVGTSGGSQLRNQPFHLKWAWISLEKEYYIVD 1773

  Fly  1706 ------EISVSSGGLLRFLPVNKL---------NVDEGGSVPIKLDFSKILEYLKTKAGI----- 1750
                  |::::..|.|....|..:         |.|..|..|.::.|:..........|:     
  Rat  1774 EDSPFFEVTLTRRGYLGGTSVISIGTKGDTAEENKDFKGKAPTRVQFNPGQSTATWNVGLIPDTK 1838

  Fly  1751 -NNPELFIEAIQKPTHGNIGLGHEFKHMQRYHPSDFFTKKVYYIHDHSDTLEDTI---LMSVY-- 1809
             ...|.|...:.:|....:    ||..|......|...:...||.:....|.:.:   |:.|.  
  Rat  1839 YETSETFQIVLSEPDMAAL----EFPEMATVEIVDPEDESTVYIPEAEYKLAEAVGEFLVPVRRS 1899

  Fly  1810 --LTQGNIFLCNL-------TIP---VSINPINDQP------FHLVTHLPQMTVVEGENRTITRN 1856
              ::|....:|:.       |||   :|::....:|      .|.          |.|.|..|..
  Rat  1900 GDISQELTVICSTRPGSAAGTIPSMELSLSDYISRPEDNRSRLHF----------EKEEREKTCQ 1954

  Fly  1857 DLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQ 1921
            .|:..|:....||.....:|.|..|.|               ..:|..|.:.             
  Rat  1955 VLIINDSLYEEEESFSIALSLPMGGRL---------------GARFPTARVT------------- 1991

  Fly  1922 STTFCFTVSDGQSNPAYEIFTIKIDSIHLQPSAMQAPVKVQQGAT------------------TA 1968
                  .::|.:..||..   .:....|::.||....|.:.:..|                  .|
  Rat  1992 ------ILADREDEPALH---FEYSEYHVEESAGSVEVAIWRRGTDLSLASSVVLRSRRTEQQAA 2047

  Fly  1969 PMRLDHIGVSTNVH------MERLSYNVTN---SPLF 1996
            ....|:||||.|:|      ::||...:.:   .|.|
  Rat  2048 EAGTDYIGVSQNLHFRPGVSVQRLRVTILDDLPQPAF 2084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058
Cadherin_3 507..664 CDD:292802 37/200 (19%)
Cadherin_3 631..776 CDD:292802 34/165 (21%)
Cadherin_3 747..892 CDD:292802 32/171 (19%)
Cadherin_3 861..1005 CDD:292802 35/168 (21%)
Cadherin_3 979..1121 CDD:292802 38/170 (22%)
Cadherin_3 1093..1242 CDD:292802 39/174 (22%)
Cadherin_3 <1264..1361 CDD:292802 25/100 (25%)
Cadherin_3 1330..1464 CDD:292802 38/143 (27%)
Cadherin_3 1436..1578 CDD:292802 39/145 (27%)
Cadherin_3 1789..1932 CDD:292802 27/165 (16%)
Cadherin_3 2009..2163 CDD:292802
Frem3NP_001178628.1 Cadherin_3 370..515 CDD:292802 31/160 (19%)
Cadherin_3 484..668 CDD:292802 37/199 (19%)
Cadherin_3 765..912 CDD:292802 28/154 (18%)
Cadherin_3 881..1026 CDD:292802 35/171 (20%)
Cadherin_3 994..1159 CDD:292802 38/170 (22%)
Cadherin_3 1125..1273 CDD:292802 38/170 (22%)
Cadherin_3 1241..1392 CDD:292802 37/162 (23%)
Cadherin_3 1361..1505 CDD:292802 38/147 (26%)
Cadherin_3 1473..1614 CDD:292802 39/145 (27%)
Cadherin_3 1583..1743 CDD:292802 51/172 (30%)
Calx-beta 1763..1850 CDD:295344 12/86 (14%)
Calx-beta 1874..1974 CDD:295344 21/109 (19%)
Calx-beta 2004..2094 CDD:295344 17/81 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I11855
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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