DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and Frem1

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001178686.1 Gene:Frem1 / 298185 RGDID:1306981 Length:2209 Species:Rattus norvegicus


Alignment Length:1958 Identity:391/1958 - (19%)
Similarity:695/1958 - (35%) Gaps:499/1958 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 IIFHVVHQPKYG---QLLQYSAEKAIFVPCRTFNLVDLATDKLKY-VHNGQENFNDHATLDMQIF 538
            ::|::...|..|   .||.::.      |..:|...||:..::.| ..|.......|..::::::
  Rat   338 LVFNITEAPLQGYVTHLLDHTR------PISSFTWKDLSDMQVAYQPPNNSHPERRHYKMELEVY 396

  Fly   539 GDV---HKIPENILGKHRFLLHANI-TPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDS 599
             |:   ...|        ..:|.:| |...:.|::..::.  |.::||..|.:..:.|.|.|.|.
  Rat   397 -DLFFERSAP--------ITVHISIRTADTNAPRVSWNTG--LNLLEGQSRAITWEQFQIVDNDD 450

  Fly   600 EPGNLIYTILPTQSPQETFGCFIVGGATTSAFSQAEVNVGKVSYLY-NSTTAESFSYELQLQVSD 663
            .....:.||...|     .|...|.......|:.|::..|.|.|.: :|.|.:.|   :..::.|
  Rat   451 IGAVQLVTIGGLQ-----HGRLTVREGKGFLFTVADLQAGVVRYHHDDSDTTKDF---VAFRIFD 507

  Fly   664 GIETSETVYLPVSVHPLELR---LVNNTGL-------IMIHKSSLPISTANLSIGTNAVDDHIDI 718
            |..:|...: |:::.|.:..   |:.|..:       |:|..|.|..|..:.|      ||:  |
  Rat   508 GQHSSHHKF-PINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSS------DDY--I 563

  Fly   719 RYDIVKAPQHGVLQRL---RQIDGSWVNVDWFSDSQLLLGHIRYLHSSDFPWQDEFKFIASFGFV 780
            .::|.|.||.|.:.:.   |.|.   ..|..|....|..|.|.|.|.....::|.|:|:      
  Rat   564 FFNITKFPQAGEIMKKPGPRLIG---YPVSGFLQRDLFSGIIYYRHFGGEIFEDSFEFV------ 619

  Fly   781 TTQTFDFRITFTRLRITSTRPSQISI--------------------NGSREILLTSDVLSYET-- 823
               .:|           |..|..:|:                    ..||.:::....::|.|  
  Rat   620 ---LWD-----------SHEPPNLSVPQVVMVHITPVDDQLPKEAPGISRHLIVKETEVAYITKK 670

  Fly   824 ----TPIGSFARSVIYKITKPTRY---------GGIYVEGS------RKAAKKLDSFT------- 862
                ....|....::|.||:|..:         |.:::..|      ...|..|:|||       
  Rat   671 HLHFLDTESHGGELVYTITRPPCFSSSHRHLDAGKLFMVDSIPKPTKNPTAPGLNSFTQVKRFGK 735

  Fly   863 -----------------------------------QQDIEKRRIRYQTHHTSYSSFSDHLEFVVS 892
                                               |..:...::.|............|::|.||
  Rat   736 TLANTVSTLLGGLGLGCSNIVISVNQCICASQFASQHAVNHMKVAYMPPMQDIGPTPRHVQFTVS 800

  Fly   893 VAE---------CDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGERALITKNHFGIR--FNI 946
            |:.         |.::. ||.::.:.|:...|        .|:|.||.:..|:..|..:.  ...
  Rat   801 VSNQHGGTLHGICFNIT-VLPVDNQVPEVFTN--------TLRVAEGGQCTISTEHILVSDVDTP 856

  Fly   947 YESLQFQVSLSPEHGVICKYDEQTGL-TTPVEMFTLEQLFRNDIYYCHDDTESTRDTFELLILSG 1010
            .:|:...:...|.||.:    |..|. ..|...|:...|....:.|.||.:|..:|...|.:..|
  Rat   857 LDSICLSLQEMPLHGGV----ELDGFPLNPRGTFSWRDLHTLKVRYQHDGSEVLQDEIFLEVTDG 917

  Fly  1011 DETDLQFVSNMEVHIKLVNDNEPYRTA-IERVFHVVRNGIRTLNPTVLQYLDADVNTNHTDIHYI 1074
            ..: ..||..:||.  .|||..|...| :..:.|....|..|:.|..:...|||.|.:.. :..|
  Rat   918 TNS-AGFVLYIEVF--PVNDEPPVLKADLIPMMHCSEGGEVTITPEYIFATDADSNDSEL-LFLI 978

  Fly  1075 HVSSTNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADSG------TASFIVTDREHEVNGLLEIR 1133
            .....:|...|:|..:|.|:|.|:.:..:.::|||.:.|      |...:|:|.|          
  Rat   979 TREPRHGVVRKAGLRVDRFSQGDVISGAVAYKHTGGEIGLESCFDTVVLVVSDGE---------- 1033

  Fly  1134 ASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKLDEIYYEVIKPPSYGILMYLSRANEGE 1198
             :||.|:....|..     ...|..:|.|                    |:|.:           
  Rat  1034 -ADPLVNGCCYNGP-----DSSVPLHKSF--------------------PTYQL----------- 1061

  Fly  1199 NGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMDKVRYRVHIKNITAEGEVMFRIYPSAYW 1263
             ..|::...|                                                       
  Rat  1062 -NITVHPVDN------------------------------------------------------- 1070

  Fly  1264 EPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYLE--MQSMSFDDE-- 1324
            :|..:....||.|:|..|..::...|.....:.:|.|:.|::.|.|..||||  :.|..|:..  
  Rat  1071 QPPSIIIGRTLTVDEGFSAALTTHHLTATDWDTAPDDLEFILVSHPQFGYLENTLPSAGFEKRNT 1135

  Fly  1325 -YNCKVFDQSSVNTEKMFYIQA---GVNQSTDYFVFDVTNGITWLRQLMIKIVIIPEK----LYM 1381
             .:...|....:....:.|:|:   ....:.|.|:...|:|.....:....::|.|..    .::
  Rat  1136 GISIASFQWRDMKASHINYVQSRHLREEPTADEFLVYATDGKQRSLETTFHVIINPTNDEAPDFV 1200

  Fly  1382 HSNIISVVEGKTVQLNPTDIQPYSEYYRGKILEYIVTITPSSGHVLA------GNSKVKRFTQKQ 1440
            ..| |:|.||..|:|:...|...........|.:.:|..|..|.:|.      .::::..|:.:.
  Rat  1201 VQN-ITVYEGHMVELDSAIISATDRDVPKDPLLFNITHKPKHGLLLISATSKDAHNEIHNFSMEL 1264

  Fly  1441 LEQG-SIQYVHNGSENATDSITLVAMARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRY 1504
            |:.| .:.|.|:.||::.|:. ::.::..|..:...:..::..||||.|.:.....:.|..|...
  Rat  1265 LQNGMKLAYAHDDSESSADNF-VIQLSDGKHKILKTVSVSITPVNDETPTLSKKAEVSVTVGDTR 1328

  Fly  1505 VIKNTDLLAQDYDTPPENLTFVVNHI-YGGYL----ARKSAPHQKIEHFTQAQINLEEIYF---- 1560
            |:.:..|.|.|.|:|.|.:.::...: ..|.|    .|...|.......||..::|..:.:    
  Rat  1329 VLSSAVLSAIDKDSPREKIHYLFERLPQNGQLQLKIGRDWVPLSAGMQCTQEDVDLNLLRYAHAG 1393

  Fly  1561 -MHDSNSRRNELSFVVTDG------------LFNTTTQMLNIEIKPIEILAEHNENLHVFPLTKK 1612
             ||..:..|  .:|.:.||            :.:|....:.|..||: ::|..:..|    ||..
  Rat  1394 KMHSQDGDR--FTFYLWDGDNRSPAFDCHIIIEDTGRGDIVIHAKPL-VVANGDRGL----LTPA 1451

  Fly  1613 QILRDYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEH---T 1674
            .:|.:    ..:|:..|:.|.||.||..|::  |::.:... .::.|:|.|:....:.|.|   |
  Rat  1452 TLLAE----DGADKAEELLYLITSPPQYGQV--EYVYSPGV-PITSFSQMDIAGQAVCYIHKSRT 1509

  Fly  1675 AVIMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLLRFLPV----NKLNVDEGGSVPIKL 1735
            ||:     :|||.|.:    |:.|..|:...||::.  |:...|||    .:|.:.||....:..
  Rat  1510 AVL-----SDSFRFTI----SNGLQTQQGVFEITLQ--GVDSALPVLTRNRRLRLVEGAMGLLST 1563

  Fly  1736 DFSKILEYLKTKAGINNPE-LFIEAIQKPTHGNIGL-GHEFKHMQRYHPSDFFTKKVYYIHDHSD 1798
            |      :|:.......|| |....:|.|.||.:.| |...:|  .:...|..::.|.|.|....
  Rat  1564 D------HLQLTDPDTPPENLTFFLVQLPRHGYLYLRGKVLQH--NFTQQDVDSRVVAYQHAGGG 1620

  Fly  1799 TLED--TILMSVYLTQGNIFLCNLTIPVSINPINDQPFHLVTHL-------PQMTVVEGENRT-- 1852
            ..||  |.|.:....||  |:.:       ..:..:|...:..:       |::|.:...::.  
  Rat  1621 AQEDCFTFLATDRKNQG--FVVD-------GKVQKEPVLFIIQVDQLDKKAPRITRLHSPSQVGL 1676

  Fly  1853 ---------ITRNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADIN 1908
                     ||.:.|...|.||..::||:.::.||..|.|...|...      ....||:|.|::
  Rat  1677 LKNGCYGIYITSHVLKASDPDTEDDQIIFKILRGPLHGRLENTTTGE------FIHEQFSQKDLS 1735

  Fly  1909 NDRIIYVHFGMPQSTTFCFTVSDGQSNPAYEIFTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLD 1973
            ...|:|:                  .||     :::::|..|:..||.     ..|.|..|.||:
  Rat  1736 RKTILYI------------------INP-----SLQVNSDILEFQAMD-----PTGNTAPPQRLE 1772

  Fly  1974 HIGVSTNVHMERLSYNV-TNSPLFGIIVYKHQPTLRFTQQQLETSQIS-------------YMQT 2024
            .  ..:.:...:..|.| .|..|..:.|.:...::......:|.:|:|             .:|.
  Rat  1773 L--KWSYIEWSQTEYEVCENVGLLTLEVTRRGYSMDSAYVDIEVNQVSAVVGKDFTVTPSKLLQF 1835

  Fly  2025 DLNRSNDSFQVSAYVPGTNYVAQVDVVMEVEPVIQINDIV-------MKEAESSGGKIKLITSLD 2082
            |...|...:.::....|   :.:.|.|.||.....:|.::       :|..:|.||:.....|.:
  Rat  1836 DPGMSTKMWNIAITYDG---LEEDDEVFEVILNSPVNAVLGTQTKAAVKILDSKGGRCHPSNSFN 1897

  Fly  2083 ND----------NPL---SLKLNKFNPKFVITRMPSTGQIRKIIRSTGLTTDGQSDRST-----N 2129
            ..          :||   |..|.......:..|.|.:......:|...||...|...:|     :
  Rat  1898 QSKHSTWGKGRWHPLPSGSSSLTTSGSPHLERRPPPSITKGDALRGFDLTDLSQRKMTTQGNGKS 1962

  Fly  2130 IFSYKELRSGVVYFVPHESVEETEADHDSFD---YQLLIKTVQPAQATVSI---EYRSRVEETET 2188
            :......|:|......:..:...:.:.|.|.   .:..|..::..|.||.:   ....:||.|..
  Rat  1963 VLPSSVCRNGTDTIYNYHGIVSLKLEGDRFSAHKRKAKISVIRQPQRTVKVAELPLADKVEPTTD 2027

  Fly  2189 VHLGSAGL 2196
            .:..|.||
  Rat  2028 SNFLSQGL 2035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058
Cadherin_3 507..664 CDD:292802 33/162 (20%)
Cadherin_3 631..776 CDD:292802 41/158 (26%)
Cadherin_3 747..892 CDD:292802 33/227 (15%)
Cadherin_3 861..1005 CDD:292802 34/197 (17%)
Cadherin_3 979..1121 CDD:292802 40/148 (27%)
Cadherin_3 1093..1242 CDD:292802 22/154 (14%)
Cadherin_3 <1264..1361 CDD:292802 24/104 (23%)
Cadherin_3 1330..1464 CDD:292802 30/147 (20%)
Cadherin_3 1436..1578 CDD:292802 34/152 (22%)
Cadherin_3 1789..1932 CDD:292802 32/162 (20%)
Cadherin_3 2009..2163 CDD:292802 32/194 (16%)
Frem1NP_001178686.1 Cadherin_3 364..508 CDD:292802 33/162 (20%)
Cadherin_3 477..622 CDD:292802 41/168 (24%)
Cadherin_3 592..729 CDD:292802 28/156 (18%)
Cadherin_3 770..917 CDD:292802 33/159 (21%)
Cadherin_3 886..1032 CDD:292802 40/149 (27%)
Cadherin_3 997..1176 CDD:292802 46/281 (16%)
Cadherin_3 1142..1292 CDD:292802 30/151 (20%)
Cadherin_3 1260..1410 CDD:292802 34/152 (22%)
Cadherin_3 1378..1523 CDD:292802 40/167 (24%)
Cadherin_3 1491..1632 CDD:292802 44/159 (28%)
Cadherin_3 1602..1760 CDD:292802 38/195 (19%)
Calx-beta 1778..1864 CDD:295344 16/88 (18%)
CLECT 2083..2205 CDD:214480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I11855
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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