DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kon and Frem2

DIOPT Version :9

Sequence 1:	NP_001260539.1	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster
Sequence 2:	NP_766450.2	Gene:	Frem2 / 242022	MGIID:	2444465	Length:	3160	Species:	Mus musculus

Alignment Length:	2252	Identity:	482/2252 - (21%)
Similarity:	788/2252 - (34%)	Gaps:	681/2252 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 SLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLEKSVFFGGVQEE 338
            |||.:::.:....|          ||:..|       |..||                 .||..|
Mouse    32 SLVSYVSTQAAGPG----------AALQSL-------GLSGT-----------------SGVPTE 62

  Fly   339 MRRRLISKGLRI---NEISFKGCMRDILVNDLPLGFAEMTISRSLALNCLWKYPCVEYNPCLKSG 400
            ....:.::|||:   .|: :...:||:::...|.....:|:..:.||             ..:.|
Mouse    63 EAIVVANRGLRVPFGREV-WLDPLRDLVLQVQPGDRCTVTVLDNDAL-------------AQRPG 113

  Fly   401 ICSQHGVDGFICYCDQSYCIKADFQGPFKI----FTETSP-----ELELLYVSPMQLLEGGTAFL 456
            ..|.   ..|.|          |: ||.::    ....||     .|:|.|.:|      |.|.:
Mouse   114 HLSP---KRFAC----------DY-GPGEVRYSHLGARSPSRDRVRLQLRYDAP------GGAIV 158

  Fly   457 SP-------HFIDIILDLRRYP-----------SLNEQSIIFHVVHQ-----------------P 486
            .|       .|..:.:..|..|           :|:::|:.|  .:|                 |
Mouse   159 LPLALEVEVVFTQLEIVTRNLPLVVEELLGTSNALDDRSLEF--AYQPETEECRVGILSGLSALP 221

  Fly   487 KYGQLLQY----------SAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDV 541
            :||:||.|          ...|.:.:.|:.|..:.     ::|.|.......:...|.|.:
Mouse   222 RYGELLHYPQVQGGAGDRGTSKTLLMDCKAFQELG-----VRYRHTAPSRSPNRDWLPMVV---- 277

  Fly   542 HKIPENILGKHRFLLHANITPINDPPQLRLHSHKILRVIEGIER-----------VLDVDLFNI- 594
                         .||:...|...|...|.|...::|:..|.|.           :::||.|.:
Mouse   278 -------------ELHSRGAPEGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLT 329

  Fly   595 ---------DDPDSEPGNLIYTILPTQSPQETFGCFIVG----GATTSAFSQAEVNVGKVSYLYN 646
                     :|.:|:|..||:.:.....|.:.   ::|.    ....|:|:|.::.:.|::|...
Mouse   330 ALTPDMLAAEDAESDPDLLIFNLTSAFQPGQG---YLVSTDDRSLPLSSFTQRDLRLLKIAYQPP 391

  Fly   647 STTAES---FSYELQLQVSDGIETSETVYLPVSVHPLELR---LVNNTGLIMIHKSSLPIS---- 701
            |..::.   |..||::...:|..:....:: |.|.|:...   :..|||||:......|::
Mouse   392 SEDSDQERLFELELEIVDPEGAASDPFAFM-VVVKPMNTLAPVVTRNTGLILYEGQYRPLTGPIG 455

  Fly   702 --TANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLH-SS 763
              ..||.|...  ||...:|.::|...:||.|..|.. ..|......|:.::|..|.:.|.| ..
Mouse   456 SGPQNLVISDE--DDLEAVRLEVVAGLRHGHLVILGS-PSSDSAPKTFTVAELAAGQVVYQHDDK 517

  Fly   764 DFPWQDEFKFIASFGFVTTQT-FDFRITFTRLRITSTRPSQISINGSREI------------LLT 815
            |....|......|.|....|. |.|.||...:   ..:|..::.|....:            |..
Mouse   518 DGSLSDNLVLRMSDGGGRHQVQFLFPITLVPV---DDQPPVLNANTGLTVAEGETVPIPPLTLSA 579

  Fly   816 SDVLSYET-------TPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRRIRY 873
            :|:.|.::       .|..|....::.:...|....|::.:......:.:..:.||||.:.::.|
Mouse   580 TDIDSDDSQLVFVLLPPFSSLGHLLLRQRHVPQEEQGLWQKQGSFYERTVTEWRQQDITEGKLFY 644

  Fly   874 QTHHTSYSSFSDHLEFVVSVAECDD---VAGV--LEINYRPPDELINKLGYQNHEPLQVQEGERA 933
            : |...:|......:|:..|.:..|   .:|:  ..|...|.|.|..:||......:.|||.:..
Mouse   645 R-HSGPHSPGPVMDQFMFRVQDNHDPPNQSGIQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLT 708

  Fly   934 LITKN--HFGIRFNIYESLQFQVSLSP-----EH-----GVICKYDEQTGLTTPVEMFTLEQLFR 986
            .:.|.  |:.........||:.|:..|     .|     |.:...|..   :..|..||..|:..
Mouse   709 PLRKRWLHYTDLDTDDRELQYTVTQPPTDTDENHSPAPLGTLVFTDNP---SVVVSHFTQAQVNH 770

  Fly   987 NDIYYCHDDTESTRDTFELLILSGDETDLQFVSNMEVHIKLVN-------------DNEPYRTAI 1038
            :.|.|        |...:.|.::......||    :|..:..|             ||:| ...:
Mouse   771 HKIAY--------RPPGQELGVAARVAQFQF----QVEDRAGNVAPGTFTLYLQPVDNQP-PEIV 822

  Fly  1039 ERVFHVVRNGIRTLNPTVLQYLDADVNTNHTDIHYIHVSST----NGAFYKSG---HYIDSFTQD 1096
            ...|.|...|...|..|.|...|.|     ||:.:|..:.|    :|....||   |....|..:
Mouse   823 NTGFTVEEKGHHILRETELHVSDVD-----TDVTHISFTLTQAPKHGHMQISGRPLHVGGQFHLE 882

  Fly  1097 DIANRRIMFQHTGADSGT--ASFIVTDREHEVNGLL--EIRASDPFVSMMATNASIVQEGKFVVL 1157
            ||.:.||.:.::|.:|.|  .|..|:||.|.|...|  .:|..|             :||...||
Mouse   883 DIKHGRISYWNSGDESLTDSCSLEVSDRHHVVPITLRVNVRPGD-------------REGPMSVL 934

  Fly  1158 KNKDFILETNLDM---KLDEIYYEVIK-----------------PPSYGILMYLSRANEGENGTT 1202
            ...  .||:.||:   ...|:...:||                 |||||.::
Mouse   935 PAG--TLESYLDVLENGATEVTANIIKGAYQGTDDLMLTFLLEGPPSYGEIL------------- 984

  Fly  1203 IYKATNYTSLSNFTHLDIERERLVYWNT--EIASMDKV------------RYRVH---IKNITAE 1250
                .|......||..||....:||.:|  ||..:.|.            .:|:.   ::.:|
Mouse   985 ----VNGAPAEQFTQRDILEGSVVYAHTSGEIGLLPKADSFNLSLSAMSQEWRIGSSIVQGVT-- 1043

  Fly  1251 GEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYLE 1315
              |...|.|.....| ::.......|.|....:||...|.....:....|:...:...|..||:|
Mouse  1044 --VWVTILPVDSQAP-EISLGEQFVVLEGDKSVISLTHLSAEDMDSLKDDLLCTIVIQPTSGYVE 1105

  Fly  1316 MQSMSFDDE----------YNCKVFDQSSVNTEKMFYIQA---GVNQSTDYFVFDVTNGITWLRQ 1367
            ..|.:...|          :..|...|..:|     |:|:   ||....|.|:|..::||.:..:
Mouse  1106 NISPAPGSEKSRAGVAISAFTLKDLRQGHIN-----YVQSVHRGVEPVEDRFIFRCSDGINFSER 1165

  Fly  1368 LMIKIVIIP---EKLYMHSNIISVVEGKTVQLN-------PTDIQPYSEYYRGKILEYIVTITPS 1422
            .:..|||||   |:..|......|:||.::.:|       ..|| |..:      |.:.:|..|:
Mouse  1166 QIFPIVIIPTNDEQPEMFMREFMVMEGMSLVVNRLILNAADADI-PRDD------LTFTITRFPT 1223

  Fly  1423 SGHV----LAGNSKVKRFTQKQ-LEQGSIQYVHNGSENATDSITLVAMARNKESVPFELEFAVVQ 1482
            .|||    :.|...|:.||..| :|..||.|.|:.||...||. ::.:...|.||...:...|:.
Mouse  1224 HGHVMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSF-VIKLTDGKHSVEKMVLIVVIP 1287

  Fly  1483 VNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIE- 1546
            |:||.|.|..|.||::..|...||.|..|:|.|.|:..::|.:::.:..|..|.::..|....|
Mouse  1288 VDDETPRMTINNGLEIEIGETKVINNKVLMATDLDSDDKSLVYIIRYGPGHGLLQRQKPLGAFEN 1352

  Fly  1547 -----HFTQAQINLEEIYFMH-DSNSRRNELSFVVTDGLFNTTTQMLNIEIKPIEILAEHNENLH 1605
                 :|||.:::...|.::| .....|:.:.|.||||......:...:.|..::|
Mouse  1353 ITLGMNFTQDEVDRNLIQYVHFGQEGIRDLIKFDVTDGTNALIDRYFYVTIGSVDI--------- 1408

  Fly  1606 VFPLTKKQILRDYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIF 1670
            |||
Mouse  1409 VFP-------------------------------------------------------------- 1411

  Fly  1671 YEHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLLRFLPVNKLNVDEGGSVPIKL 1735
                              ||                  ||.|          :::.|||.|.:..
Mouse  1412 ------------------DV------------------VSKG----------VSLKEGGKVTLTT 1430

  Fly  1736 DFSKILEYLKTKAGINNPE--LFIEAIQKPTHGNI------GLG-HEFKHMQRYHPSDFFTKKVY 1791
            |       |.:.:.:|:|:  |.....:.|..|::      ||. ..|..:|      ....|:|
Mouse  1431 D-------LLSTSDLNSPDENLVFTITRAPMRGHLECTDRRGLSITSFTQLQ------LAGNKIY 1482

  Fly  1792 YIHDHSDTLEDTILMSVY---LTQGN--IFLCNLTIPVSINPI-NDQPFHLVTHLPQMTVVEGEN 1850
            |||    |.||.:.|..:   :|.|.  :|   .|..:||:.: |.:|   |..:..:.|.|.|:
Mouse  1483 YIH----TAEDEVKMDSFEFQVTDGRNPVF---RTFRISISDVDNKKP---VVTIHNLVVSESES 1537

  Fly  1851 RTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQ-----FTQADINND 1910
            :.||..:|..||.|||...:.:.|...|..|             .|.|:|.     ||:.|:|.:
Mouse  1538 KLITPFELTVEDRDTPDRLLKFIVTQVPVHG-------------HLLFNNTRSVMVFTKQDLNEN 1589

  Fly  1911 RIIYVHFGMPQST--TFCFTVSDGQSNPAY----EIF------TIKIDSIHLQPSAMQAPVKVQQ 1963
            .|.|.|.| .:||  :|.|||:||..:..|    .:|      .:||..:.:..|..|  :.|.:
Mouse  1590 LISYKHDG-TESTEDSFSFTVTDGTHSDFYVFPDTVFETRRPQVMKIQVLPVDNSVPQ--IVVNK 1651

  Fly  1964 GATT-APMRLDHIGV-----------STNVHMERLSYNVTNSPLFGIIVY----KHQPTLRFTQQ 2012
            ||:| ..:...|:|.           ..::|.. |.:.||.:|..|.::.    .|..| :|||.
Mouse  1652 GASTLRTLATGHLGFMITSKILKVEDRDSLHFS-LRFIVTEAPQHGYLLNLGQGNHSVT-QFTQA 1714

  Fly  2013 QLETSQISY-MQTDLNRSNDSFQVSAYVPGTNYVAQVD-------VVMEVEPVIQIN------DI 2063
            .::..:|.| ::...|.::|.|.......|.|.:....       :..|.|..: ||      ||
Mouse  1715 DIDDMKICYVLRERANATSDMFHFIVEDDGGNRLTNQHFRLNWAWISFEKEYYL-INEDSKFLDI 1778

  Fly  2064 VMKEAESSGGKIKLIT------SLDNDNPLSLKLNK---FNPKFVITRMPSTGQIRKIIRSTGLT 2119
            |:.. ....|:...|:      :.:.|.....|..|   |||          ||.|...| ..:.
Mouse  1779 VLTR-RGYLGETSFISIGTRDGTAEKDRDFKGKAQKQVQFNP----------GQTRASWR-VRIL 1831

  Fly  2120 TDGQSDRSTN-----------IFSYKELRSGVV--------YFVPHE--SVEETEAD-----HDS 2158
            :||:.:.|..           |..:..:.:..:        .|:|..  ||||...:     ..|
Mouse  1832 SDGEHEHSETFQVVLSEPVLAILEFPTVTTVEIIDPGDESTVFIPQSEYSVEEDVGELFIPIRRS 1896

  Fly  2159 FDYQ---LLIKTVQPAQATVSI--------EYRSRVEETETV 2189
            .|..   ::|...|...||.::        :|.||.|:..:|
Mouse  1897 GDISRELMVICYTQQGTATSTVRTSVLSYSDYISRPEDHSSV 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kon	NP_001260539.1	LamG	30..176	CDD:238058
		LamG	211..365	CDD:238058	19/93 (20%)
		Cadherin_3	507..664	CDD:292802	33/184 (18%)
		Cadherin_3	631..776	CDD:292802	37/157 (24%)
		Cadherin_3	747..892	CDD:292802	31/165 (19%)
		Cadherin_3	861..1005	CDD:292802	36/160 (23%)
		Cadherin_3	979..1121	CDD:292802	40/163 (25%)
		Cadherin_3	1093..1242	CDD:292802	44/186 (24%)
		Cadherin_3	<1264..1361	CDD:292802	23/109 (21%)
		Cadherin_3	1330..1464	CDD:292802	45/151 (30%)
		Cadherin_3	1436..1578	CDD:292802	46/149 (31%)
		Cadherin_3	1789..1932	CDD:292802	49/155 (32%)
		Cadherin_3	2009..2163	CDD:292802	41/205 (20%)
Frem2	NP_766450.2	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	312..406		18/96 (19%)
		Cadherin_3	376..532	CDD:292802	38/159 (24%)
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	431..530		25/101 (25%)
		Cadherin_3	500..665	CDD:292802	32/168 (19%)
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	553..664		17/111 (15%)
		Cadherin_3	634..797	CDD:292802	40/178 (22%)
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	689..796		24/121 (20%)
		Cadherin_3	763..909	CDD:292802	40/163 (25%)
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	817..908		26/96 (27%)
		Cadherin_3	879..1026	CDD:292802	44/178 (25%)
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	934..1026		24/110 (22%)
		Cadherin_3	993..1159	CDD:292802	38/175 (22%)
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1055..1157		23/107 (21%)
		Cadherin_3	1125..1273	CDD:292802	46/160 (29%)
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1178..1271		29/100 (29%)
		Cadherin_3	1241..1390	CDD:292802	46/149 (31%)
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1292..1388		25/95 (26%)
		Cadherin_3	1359..1503	CDD:292802	46/277 (17%)
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1409..1501		32/216 (15%)
		Cadherin_3	1471..1612	CDD:292802	51/170 (30%)
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1521..1610		32/105 (30%)
		Cadherin_3	1581..1742	CDD:292802	44/165 (27%)
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1644..1741		23/100 (23%)
		Calx-beta	1760..1847	CDD:295344	22/99 (22%)
		Calx-beta	1871..1971	CDD:295344	17/68 (25%)
		Calx-beta	1999..2091	CDD:295344
		Calx-beta	2117..2209	CDD:295344
		Calx-beta	2239..2330	CDD:295344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3130..3160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12109
eggNOG	1	0.900	-	-		E1_KOG3597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810