back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kon and Fras1

DIOPT Version :10

Sequence 1:	NP_609881.3	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster
Sequence 2:	NP_780682.3	Gene:	Fras1 / 231470	MGIID:	2385368	Length:	4010	Species:	Mus musculus

Alignment Length:	2266	Identity:	455/2266 - (20%)
Similarity:	799/2266 - (35%)	Gaps:	628/2266 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 FAEMTISRSLA-----LNCLWKYPC--VEYNPCLKSGICSQHGVDGFICYCDQSYCIKADFQGPF 428
            ||:....|.:|     |.|..|..|  .:::..||||:|....|.||..:.....|..
Mouse  1040 FADHAKHRCIACPQGCLRCSHKDRCHLCDHSFFLKSGLCMPTCVPGFSGHSSNENCTD------- 1097

  Fly   429 KIFTETSPELELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQLL- 492
            |::|.:      |:|:....|  |...:.|  :|..|...::.....:.::||||..|..||||
Mouse  1098 KMYTPS------LHVNGSLTL--GIGSMKP--LDFSLLNIQHQDGRVEDLLFHVVSTPTNGQLLL 1152

  Fly   493 -----QYSAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATL---DMQIFGDVHKIPENIL 549
                 :...|||     ..|:..|:...|:::||:.::....:.:|   |.|.|.:    |:
Mouse  1153 SRNGKEVQLEKA-----GHFSWKDVNEKKVRFVHSKEKLRKGYFSLKISDQQFFSE----PQ--- 1205

  Fly   550 GKHRFLLHANITPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSP 614
                 |::........|..||   :::|.|.:|....:...|.:|.| |..|.:::..:|.....
Mouse  1206 -----LINIQAFSTQAPYVLR---NEVLHVSKGERATITTQLLDIRD-DDNPQDVVVNVLDPPLH 1261

  Fly   615 QETFGCFIVGGATTSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHP 679
            .:.........|:...|...|::.|.:.|.::.  ::|.|..:..|.:|| .:.:.:...|...|
Mouse  1262 GQLLQMPPAPAASIYQFHLDELSRGLLLYAHDG--SDSTSDIIVFQANDG-HSFQNILFHVKNIP 1323

  Fly   680 LE---LRLVNNTGLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKA-PQHGVLQRLRQI--- 737
            ..   ||||.|:.:.:.....|.|:...|......|... ||.|.|..: ||.|.:..|..:
Mouse  1324 KNDRALRLVTNSMVWVPEGGMLKITNRILKAQAPGVRAD-DIIYKITHSRPQFGEVVLLMNLPAD 1387

  Fly   738 -------------DGSWVN-VDWFSDSQLLLGHIRYLHSSDFPWQDEFKFIASFGFVTTQTFDFR 788
                         ||.... :..|:...:..|.:.|.|.......|.|:|..|......:..:..
Mouse  1388 SPAGPAEEGHHLPDGRMATPISTFTQQDIDDGVVWYRHLGAPTQSDSFRFQVSSATSAQEHLESH 1452

  Fly   789 ITFTRLRITSTRPSQISINGSREILLTSDVLSYETTPIGSFARS------VIYKITKPTRYGGIY 847
            :....:...:....::|:..|..:....|.||.......||.::      :||.||.|.......
Mouse  1453 MFNIAILPQAPEAPKLSLGTSLHMTAREDGLSVIQPQSLSFVKAESPSGKIIYNITVPLHPNQGI 1517

  Fly   848 VEGSRKAAKKLDSFTQQDIEKRRIRYQ-----THHTSYSSFS-----DHLEFVVSVAECDDVA-- 900
            :|...:....:..|||:||.:.:|.|:     .|.....:||     :.::|..:|::....:
Mouse  1518 IEHRDRPHSPIQYFTQEDINQGQIMYRPPVAPPHLQEIMAFSFAGLPESVKFYFTVSDGQHTSPE 1582

  Fly   901 -----GVLEINYRPPDELINKLGYQNHEP-LQVQEGERALITKNHFGIRFNIY------ESLQFQ 953
                 .:|..:.:||       .:|...| |:|..|.|..:     |::..:.      |.|.||
Mouse  1583 MALTIHLLHSDLQPP-------AFQVKAPLLEVSPGGRTSL-----GLQLLVRDAQVVPEELFFQ 1635

  Fly   954 VSLSPEHGVICKYDEQTGLTTPV-EMFTLEQLFRNDIYYCHDDTESTRDTFELLILSGDETDLQF 1017
            :..||:||::.||..::.:|... :.||.:::.||.:.|.||.:.:..|:.|:.:     ||...
Mouse  1636 LQKSPQHGMLVKYTAKSSVTMAAGDTFTYDEVERNVLQYVHDGSSAWEDSLEISV-----TDGLT 1695

  Fly  1018 VSNMEVHIKL-VNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDADVNTNHTDIHYIHVSSTN- 1080
            |:..||.::: .::|...|.|..          .:|:.||.....|.:..:|  :.|:..||::
Mouse  1696 VTTSEVKVEVSPSENRGPRLAPG----------SSLSMTVASQHTAIITRSH--LAYVDDSSSDP 1748

  Fly  1081 ------------GAFYK-SGHYID------SFTQDDIANRRIMFQ-------HTGADSGTASFIV 1119
                        |..:: ||..:|      :||.:||..:.|.:.       |:..|....|...
Mouse  1749 EIWIRLSSLPLYGVLFRSSGPDMDELSGDSNFTMEDINKKNIRYSAVFETDGHSVTDGFHFSVSD 1813

  Fly  1120 TDREHEVNGLLEIR---ASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKLDEIYYEVIK 1181
            .|..|..|.:..|.   |.:|...:...:...|.||....|....|....:.|...|:...::..
Mouse  1814 MDGNHVDNQVFTITVTPAENPPHIIAFADLITVDEGGRAPLSLHHFFATEDQDNLQDDAVIKLSA 1878

  Fly  1182 PPSYGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMDKV-------- 1238
            .|.||.:     .|.| .|.......|....::|...|:....:.|:.:...|::..
Mouse  1879 LPKYGCI-----ENTG-TGDRFGPGANSELEASFPIQDVLENYIYYFQSVHESIEPTHDVFSFYV 1937

  Fly  1239 -----RYRVHIKNITAE---GEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPN 1295
                 |..:|..|||.|   .|.     |.....||.|:.        |:.|.||...|.:...:
Mouse  1938 SDGSGRSEIHSINITIERKNDEP-----PRMTLRPLGVRL--------SSGVAISNSSLSLQDLD 1989

  Fly  1296 ISPGDITFLVTSSPMHGYLEMQSMSFDDEYNCKVFDQSSVNTEK------MFYIQAGVNQSTDYF 1354
            ....::.|::...|.||:|..:|.:.|...|..|.||.|..|.:      :.|:...:..:.|.|
Mouse  1990 TPDNELIFVLMKKPDHGHLLRRSTASDPLENGTVLDQGSSFTYQDVLAGLVGYLPGDIYMAVDEF 2054

  Fly  1355 VFDVTNGI---TWLRQLMIKIVIIPEKLYMHSNIISVVEGKTVQLNPTDIQPYSEYY-------- 1408
            .|.:|:|:   |...::.|:   :|.     :||..:...:.:||:...:...:|.:
Mouse  2055 RFSLTDGLHVDTGRMEIYIE---LPS-----TNIPHLAINRGLQLSAGSVARITEQHLKATDTDS 2111

  Fly  1409 -RGKILEYIVTITPSSGHVLAGNS----------KVKRFTQKQLEQGSIQYVHNGSE---NATDS 1459
             .|::: ||:...|.:|.:|...:          .::.|||..:.||.|:|.|...|   :....
Mouse  2112 EAGQVV-YIMKEDPGAGRLLMAKADNLEQISVRGPIRSFTQADVSQGQIEYSHGPGEPGGSFAFK 2175

  Fly  1460 ITLVAMARNKESVPFELEFAVVQVNDEE-PMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENL 1523
            ..:|....||.:   :..|::..:.|:. |:::||.||.:.......|....|.|.|.|:.|..|
Mouse  2176 FDVVDGEGNKLA---DQSFSIGVLEDKSPPVVITNRGLVLDENSVEKITTAQLSATDQDSKPTEL 2237

  Fly  1524 TF-VVNHIYGGYLARKSAPHQKIEHFTQAQINLEEIYFMHDSNS--RRNELSFVVTDGLFNTTTQ 1585
            .: :......|:|...::|..:|..||||.:....:.::..|.:  :.:..|||::||| :..||
Mouse  2238 IYRITTQPQLGHLEHVASPGIQISSFTQADLASRNVQYVRSSGTGKQSDAFSFVLSDGL-HEVTQ 2301

  Fly  1586 MLNIEIKPIEILAEHNENLHVFPLTKKQILRDYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDN 1650
            ...|.|.|::         ...||.:.:.:|                               :..
Mouse  2302 TFPITIHPVD---------DARPLVQNRGMR-------------------------------VQE 2326

  Fly  1651 GFTKEVSEFTQNDVDNGHIFYEHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLL 1715
            |..|.::||....||                      .|..||          :|..::
Mouse  2327 GVRKTITEFELKAVD----------------------VDTEAE----------SITFTI------ 2353

  Fly  1716 RFLPVNKLNVDEGGSVPIKLDFSKILEYLKTKAGINNPELFIEAIQKPTHGNI---GLGHEFKHM 1777
                                                        :|.|.||.|   ..|..|...
Mouse  2354 --------------------------------------------VQPPRHGTIERTARGQRFHQT 2374

  Fly  1778 QRYHPSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCN------LT-----IPVSINPIND 1831
            ..:...|.:..:|.|.||.|::|:|....:|.......|:..      :|     ..|.|.|::|
Mouse  2375 SSFTMEDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGEEIMTAAPQQFHVDILPVDD 2439

  Fly  1832 QPFHLVTH--LPQMTVVEGE-NRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPE 1893
            ....:||:  |..:..::|: ...||:.:|||.|.||...::||:|.:||..|.|......||.
Mouse  2440 GTPRIVTNLGLQWLEYMDGKATNLITKKELLTVDPDTEDSQLIYEVTTGPMHGYLENKLQPGRA- 2503

  Fly  1894 DLLAFSNQFTQADINNDRIIYVHFG---MPQSTTFCFTVSDGQSNPA--------YEIFTIKIDS 1947
                 :..|||..:|...|.||.:.   .....:|.|.|.|.:.|..        :.:.:.|..|
Mouse  2504 -----AATFTQEHVNLGLIRYVLYEEKIQKVMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTS 2563

  Fly  1948 IHLQPSAMQAPVKVQ----------------QGATTA---PMRLDHIGVSTNVHMER-------- 1985
            .::...|....|.||                ||..::   |.:.|::..:..|..:.
Mouse  2564 YNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSHPGQQDYMEYAGQVQFDEGEGTKSCT 2628

  Fly  1986 ------------LSYNV-TNSPLFGII-----------VYKHQPTLRFTQQQLETSQ-ISYMQTD 2025
                        .|:.| .:.|.:.::           ..:.:|||.|.::....:: ..::...
Mouse  2629 VIINDDDVFENIESFTVGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAP 2693

  Fly  2026 LNRSNDSFQ-VSAY---VP-------------GTNYVAQ-----------VDVVMEVEPVIQIND 2062
            :.|..||.. |||.   ||             |:::.::           ..|.:....|:.|:|
Mouse  2694 IKRQGDSSSTVSAVCYTVPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPGVTVSTCDVMVIDD 2758

  Fly  2063 IVMKEAE---------SSGGKI------KLITSLDND-NPLSLKLNKFNPKFVITRMPSTGQIRK 2111
            ...:|.|         |:..:|      |::.|..|| :.:||.    |..|.|:....|.:|..
Mouse  2759 SEYEEEEEFEIALADASNNARIGRQAVAKVLISGPNDASTVSLG----NTAFTISEDAGTVKIPV 2819

  Fly  2112 IIRSTGLTTDGQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQPAQATVS 2176
            |...|.|:|      .|:::                               ...:...||.||..
Mouse  2820 IRHGTDLST------FTSVW-------------------------------CATRPSDPASATPG 2847

  Fly  2177 IEYRSRVEETETVHLGSAGLSINYLAI------------GCAIFIVLICLLIVLLILKIRKLRKH 2229
            ::|   |..:..|..| .|::..|..:            |...|:|.:.             ...
Mouse  2848 VDY---VPSSRKVEFG-PGITEQYCTLTILDDTQYPVIEGLETFVVFLS-------------SAQ 2895

  Fly  2230 KADISK------------DQPPALPCPPDLTSVSPQHHLHH------------------HHGHHY 2264
            .|:::|            ...|::....||..|..:..:.|                  ..||..
Mouse  2896 GAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVKEKEGVLHIPIIRSGDLSYESSVRCYTQGHSA 2960

  Fly  2265 ASSE-------ADSVPAT---GNSTPLPGFSNIPHCKIIPVESYKHEYPDYDPDEE 2310
            ...|       |||...|   |..|        .:|.:     |.|:...::|:|:
Mouse  2961 QVMEDFEERRNADSSRITFLKGQKT--------KNCTV-----YIHDDSMFEPEEQ 3003

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.