DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and C48E7.6

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001361945.1 Gene:C48E7.6 / 172317 WormBaseID:WBGene00016751 Length:1996 Species:Caenorhabditis elegans


Alignment Length:2266 Identity:517/2266 - (22%)
Similarity:908/2266 - (40%) Gaps:439/2266 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 ILLEIEDQHLKVTFNKAGSLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANET 320
            |:|....::|.::|:........:....||:.:.....|:   .|:.:||.     ::..|||..
 Worm    30 IILSTPSKNLSLSFHNGHIYADSIPVSAISENETTSFSLK---CISHISLH-----FQSPHANSL 86

  Fly   321 KASINLEKSVFFGGVQEEMRRRLISKGLRINEISFKGCMRDILVNDLPLGFAEMTISRSLALNCL 385
            ..|..|..:.              :.||.|||.:.||||.||..:                    
 Worm    87 VYSPTLCSAP--------------NIGLTINETALKGCMFDITQS-------------------- 117

  Fly   386 WKYPCVEYNPCLKSGICSQHGVDGFICYCDQSYCIKADFQGPFKIFTETSPELELLYVS-PMQLL 449
                         |.|.:|.     ||..|.....|...:||             :||: |::|.
 Worm   118 -------------SSILTQR-----ICGIDSKNAAKNPEKGP-------------IYVAEPVELN 151

  Fly   450 EGGT-------AFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEKAIFVPCRTF 507
            |||:       .:..|...|:        :.:...|.|.:|...|:|::      :...|...:|
 Worm   152 EGGSMPLQWKNVYFMPSSQDV--------NFSHTDIFFTIVESAKHGEV------RIDDVVTSSF 202

  Fly   508 NLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHK--IPENILGKHRFLLHANITPINDPPQL- 569
            ....|...::.|.|:|.|...|..:..:: |...||  ||..   ...:.|...|..:||||:| 
 Worm   203 TYAQLLARRVIYKHDGTETREDRLSFQIE-FAVKHKQLIPAE---SKTYSLRIKINGVNDPPELV 263

  Fly   570 -RLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFI-VGGATTSAFS 632
             |....|:|....| .||:..::..:.|.|..|..:...::      |:.|..| |.|...:.||
 Worm   264 KRSKDEKLLIASRG-SRVITNEILILTDADDRPEKVRVQVV------ESSGVHIEVHGQKVNEFS 321

  Fly   633 QAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLELRLVNNTGLIMIHKSS 697
            ..::....||.:...|  |..|..::|...|....|..|.|......::::||:||||.::|.||
 Worm   322 HKQLIEELVSLVDEGT--ELGSGRIRLIARDREARSGVVILETQSTKVDVKLVHNTGLKLLHHSS 384

  Fly   698 LPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLHS 762
            ..::..|||... ::.|.| :.|.||..|..||::.|::.|..:.....|:.:|:....:|:.|:
 Worm   385 ALLTNKNLSFDA-SIQDMI-VAYRIVDMPDTGVVECLQENDDKFSMCTTFTQAQVNEEQVRFRHT 447

  Fly   763 --SDFPWQDEFKFIASFGFVTTQTFDFRITFTRLRITSTRPSQISINGSREILLTSDVLSYETTP 825
              |..| .|.|.|....|...:....|||.|..:.|.........:||:..:.::...|...|.|
 Worm   448 SQSSSP-SDMFSFQVEAGEFASMVHVFRIDFIPMNIKVFTREPFVLNGTETMSISRQNLFSWTFP 511

  Fly   826 IGSFARSVIYKITKPTRYGGIYVEGSRKAA----KKL---DSFTQQDIEKRRIRYQTHHTSYSSF 883
            ....|.::||.|.:|.:.|.:    |||.|    :::   .:||||||::..|.|:.|:..||..
 Worm   512 KSFSAHNLIYHIDEPPKLGTL----SRKLAVGKQRRIGVSSNFTQQDIDEGAISYKLHYQQYSIV 572

  Fly   884 SDHLEF-VVSVAECDDVAGVL---EINYRPPD---ELINKLGYQNHEPLQVQEGERALITKNHFG 941
            :|...| |||.|    |:..|   :|.|.|.:   .|:||       .:.|:|.|.|.||.:...
 Worm   573 NDFFVFRVVSPA----VSSPLLRFDIVYVPKESSIRLVNK-------TIVVKEEEIASITPDFLS 626

  Fly   942 IRFNIYESLQFQVSLSP--------EHGVICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTES 998
            :......:..|:| :||        :.|.:.|.|..         ||.:.:.::.:.|.|...|:
 Worm   627 LSTPDDSNFIFRV-VSPTLHGQIRLQIGEVLKKDSN---------FTSDDIAKHRLTYSHSGDET 681

  Fly   999 TRDTFELLILSGDETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDAD 1063
            ..|...||.:|......:....:...|.|:|||.| :.|.....::|..|.|.|:|.:|.::|.|
 Worm   682 RTDECRLLAISRQNPMRKVPLTLSFSIILLNDNAP-KLAQNVTVYMVERGERVLHPFLLPWVDED 745

  Fly  1064 VNTNHTDIHYIH-----VSSTNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADSG-TASFIVTDR 1122
            |:.:.....:..     :.||...:..    :.||||.||...::|.:|.|.... ...:.|:|.
 Worm   746 VDASALMFDFTQNKDAAILSTVSPYLP----LTSFTQHDIDEGKVMIRHLGHHGEFYIGYTVSDG 806

  Fly  1123 EHEVNGLLEIRASDPFVSMMATNASIVQEGKF---VVLKNKDFILETNLDMKLDEIYYEVIKPPS 1184
            .|.|.|.:.:.|:.|.|.:......::....|   :.|.:.:..:.||||::|::|.|..     
 Worm   807 VHRVEGKMHVLAAKPDVWIEKAEIVLICGAHFPQTIRLSSNNLTVLTNLDVRLEDIIYSC----- 866

  Fly  1185 YGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMDKVRYRVHIKNITA 1249
                        ..|.:..:..:.......|:..|||.|.:.|......|:::::..|..:|:  
 Worm   867 ------------SSNFSRFFVGSQRKPARGFSQKDIENESVWYSVPNEDSIERLKVAVADRNL-- 917

  Fly  1250 EGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGD----ITFLVTSSPM 1310
              ||..|:...........:|:..|.|....:|||.:::||     ||..|    |.:.|...|.
 Worm   918 --EVELRVRCENSRGSFSYQQHRMLRVPVGGAVLIDKNLLE-----ISLVDAERPIIYKVMKQPN 975

  Fly  1311 HGYLEMQSMSFDDEYNCKV--FDQSSVNTEKMFYIQAGV---NQSTDYFVFDVTNGITWLRQLMI 1370
            :|||   |:.::..::.::  |..:.|.:..:.|:....   |.|.|:.|..::..:::  .|.:
 Worm   976 NGYL---SLDYEKSFSSRISTFTDTDVTSGSVQYVHNNADHSNDSIDFQVHVISRNLSF--HLKL 1035

  Fly  1371 KIVIIPEKLYMHSNIISVVEGKTVQLNPTDIQPYSEYYRGKILEYIVTIT--PSSG-------HV 1426
            :|.:....:.:.:::.||.....|.:...    :.:....:..|.::|:.  |:||       |.
 Worm  1036 EIDVFQRNITISTSLFSVPAAGRVPITSN----FLKVTTSENEEAVITVVSPPTSGWVTTDSVHN 1096

  Fly  1427 LAGNSKVKRFTQKQLEQGSIQYVHNGSENATDSITLVAMARNKESVPFELEFAVVQVNDEEPMMV 1491
            :...|.:..||.:.:|.|.:.:|.:|| :..|||.:.|...::.:....::..|.::|::.|:|:
 Worm  1097 ITSISSIATFTTRMIENGQVWFVSDGS-HGNDSIGVRACVHDQCTGIHLMQITVSRINEKGPVMI 1160

  Fly  1492 TNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIEHFTQAQINLE 1556
            .|..|:| :|.:.:|.|:.|..:|.|||..::|:::.....|.:.:.|...:.:.:|||..|:..
 Worm  1161 RNEVLRV-SGNKALITNSHLDVEDTDTPTNSITYIIAQPSNGRVVKASQMEEVMTNFTQFDIDQS 1224

  Fly  1557 EIYFMHDSNSRR-NELSFVVTDGLFNTTTQMLNIEIKPIEILAEHNENLHVFP----LTKKQILR 1616
            .:.|:..::|.. ...||.||||......:..:.|:.....:.|.|..|...|    :...::||
 Worm  1225 NVAFLATNHSNPFGGFSFHVTDGKHKIGPEWFSTELSSSSTILEANGRLVASPSSATVIGTELLR 1289

  Fly  1617 DYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEHTAVI--ME 1679
            ..:.....|   ||.:.|..|...|.|:.:.|.|      :.|||..::...:.|......  .|
 Worm  1290 GNMPGTRPD---EIIFTILKPARYGEILVDGIKN------TVFTQLQINRRQVVYSTVGFSDQNE 1345

  Fly  1680 FRTNDSFYFDVVAERSDRLL--NQKFNIE---ISVSSGGLLRFLPVNKLNVDEGGSVPIK---LD 1736
            :...|||.|.|....|.:.|  |:||.|.   .::|...|.:::....|.|..|||....   ||
 Worm  1346 WSRRDSFSFRVHKNNSAQFLNSNEKFRITTTFAAISDKVLSKYITTRPLVVSRGGSACFNQSHLD 1410

  Fly  1737 FSKILEYLKTKAGINNPELFIEAIQKPTHGNIGLGHEFKHMQRYHPSDFFTK-----KVYYIHDH 1796
            .|.:.:      .::...:.||...:|..|.:    |:...:|...|  :|:     .:.|.|..
 Worm  1411 VSALAD------AVDKEIVMIEIGTEPRAGTL----EWLDNERNRVS--WTELRTSFHLLYKHTA 1463

  Fly  1797 SDTLEDTILMSVYLTQGNIFLCN---LTIPVSINPINDQPFHLVTHLPQMTVVEGENRTITRNDL 1858
            :|:|.|:::..:|..:.:....:   :::.:.|....|....:|.....::::...:..:..:.|
 Worm  1464 TDSLSDSLIFHIYAARESTRRASRIRISVDIQITNPPDPDVQVVLFPDSVSILNSGSTPLLADIL 1528

  Fly  1859 LTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFG---MP 1920
            :|.....||:.|:|........||..:     |.:|.:   .||:|.|:|:.:|...|..   .|
 Worm  1529 MTRHKTVPPQSIVYSTQQRGANGVTIR-----RGDDEI---KQFSQQDVNDGKISIWHTANRHQP 1585

  Fly  1921 QSTTFCFTVSDGQSNPAYEIFTIK-IDSIHLQPSAMQAPVKVQQGATTAPMRLDHIGVSTNVHME 1984
            .:|.....|.|.:.:....|..|: :|.:....:.:..|    ||.|...:..:|:|..:..:..
 Worm  1586 AATWHDVIVLDIEGHTRSLIIDIRPLDLMLKNHTTIWYP----QGKTYVVLNSEHLGAFSMGNRS 1646

  Fly  1985 RLSYNVTNSPLFGII--VYKHQPTLRFTQQQLETSQISYMQTDLNRSNDSFQV-----SAYVPGT 2042
            .|.|.:|:.|..|..  |...:....|:|:.::..::.|.|.:::..:|.|..     |..|...
 Worm  1647 TLKYKITSGPENGTFYWVAGEKEAKEFSQKDIDEGRVLYAQLNMHSFHDKFDFVVENDSRDVLRN 1711

  Fly  2043 NYVAQVDVVMEVEPVIQINDIVMKEAESSGGKIKLITSLDNDNPLSLKLNKFNPKFVITRMPSTG 2107
            :...:|..::.|:|||       .||:::   ..|.||..|.:.|   ||. :|:|.:|.....|
 Worm  1712 SSELRVRALVSVQPVI-------VEADTA---TPLTTSQINASTL---LNS-SPRFFLTSPLKFG 1762

  Fly  2108 QIRKIIRSTGLTTDGQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQPAQ 2172
            :         ||.|..::.||..|:..:::.|:||:....:.||.   |:....::....||||:
 Worm  1763 R---------LTFDPNTNYSTYYFTNTDIQKGIVYYKAFSTEEEV---HEIVQLEVRADNVQPAR 1815

  Fly  2173 ATVSIE-YRSRVE--------------------ETETVHLGSAGLSINYL-AIGCAIFIVLICLL 2215
            .|:.|. .|:.:|                    .|:....|...|.:..| ||..|...||||..
 Worm  1816 FTLPITILRADMENYDPSTTGDQMIPYSNGGSDSTKFSIFGENNLPVVILGAIVAATIFVLICRR 1880

  Fly  2216 IVLLILKIRKLRKHKADISK--DQPPALP----------CPPDL--TSVSPQHHLHHHHGHHYAS 2266
            ..    :.:|..|.:..|:.  |.|..||          .||||  |:|             :| 
 Worm  1881 CG----EGKKKNKTRTPINAKLDTPTRLPPSPSESIDHEKPPDLLGTTV-------------FA- 1927

  Fly  2267 SEADSVPATGNSTPLPGFSNIPHCKIIPVESYKHEYPDYDPDEEETDDQCDPQQMMLPQRYNPYH 2331
                ||....:...:..|:..|.    |..|...:.|:                   |:|.|...
 Worm  1928 ----SVRQAEDRMTMKSFNKPPK----PESSSSRKPPN-------------------PRRQNVSS 1965

  Fly  2332 MEHDAWSSSCDMANDFAGYASVPQSISGSVSSPP------SAPPTNPLLRRNQYWV 2381
            :             |:||..|         .:||      ....|.|   .|.|||
 Worm  1966 L-------------DYAGITS---------DTPPPMRLFEQVAQTQP---TNHYWV 1996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058 26/108 (24%)
Cadherin_3 507..664 CDD:292802 41/161 (25%)
Cadherin_3 631..776 CDD:292802 43/146 (29%)
Cadherin_3 747..892 CDD:292802 44/154 (29%)
Cadherin_3 861..1005 CDD:292802 44/158 (28%)
Cadherin_3 979..1121 CDD:292802 37/147 (25%)
Cadherin_3 1093..1242 CDD:292802 33/152 (22%)
Cadherin_3 <1264..1361 CDD:292802 25/105 (24%)
Cadherin_3 1330..1464 CDD:292802 29/145 (20%)
Cadherin_3 1436..1578 CDD:292802 39/142 (27%)
Cadherin_3 1789..1932 CDD:292802 29/148 (20%)
Cadherin_3 2009..2163 CDD:292802 38/158 (24%)
C48E7.6NP_001361945.1 Cadherin_3 <146..230 CDD:374418 20/97 (21%)
Cadherin_3 244..344 CDD:374418 28/108 (26%)
Cadherin_3 371..461 CDD:374418 31/92 (34%)
Cadherin_3 468..580 CDD:374418 33/115 (29%)
Cadherin_3 606..685 CDD:374418 20/95 (21%)
Cadherin_3 698..806 CDD:374418 28/112 (25%)
Cadherin_3 <937..1022 CDD:374418 23/92 (25%)
Cadherin_3 <1057..1129 CDD:374418 16/76 (21%)
Cadherin_3 1143..1247 CDD:374418 28/104 (27%)
Cadherin_3 1266..1356 CDD:374418 24/98 (24%)
Cadherin_3 1488..1579 CDD:374418 19/98 (19%)
Cadherin_3 <1648..1701 CDD:374418 12/52 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167229
Domainoid 1 1.000 55 1.000 Domainoid score I7483
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 349 1.000 Inparanoid score I1343
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46545
OrthoDB 1 1.010 - - D119072at33208
OrthoFinder 1 1.000 - - FOG0003479
OrthoInspector 1 1.000 - - oto17190
orthoMCL 1 0.900 - - OOG6_106870
Panther 1 1.100 - - LDO PTHR15036
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4086
SonicParanoid 1 1.000 - - X2369
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.800

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