DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and FREM1

DIOPT Version :10

Sequence 1:NP_609881.3 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:XP_016869805.1 Gene:FREM1 / 158326 HGNCID:23399 Length:2188 Species:Homo sapiens


Alignment Length:1944 Identity:400/1944 - (20%)
Similarity:718/1944 - (36%) Gaps:507/1944 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 IIFHVVHQPKYG---QLLQYSAEKAIFVPCRTFNLVDLATDKLKYV---HNGQENFNDHATLDMQ 536
            ::|::...|..|   .||.::.      |..:|...||:..::.|.   .:..|..:|...|::.
Human   341 LVFNITKAPLQGYVTHLLDHTR------PISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVY 399

  Fly   537 IFGDVHKIPENILGKHRFLLHANI-TPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSE 600
            .|......|..:        |.:| |...:.|::..::.  |.::||..|.:..:.|.:.|.|..
Human   400 DFFFERSAPMTV--------HISIRTADTNAPRVSWNTG--LSLLEGQSRAITWEQFQVVDNDDI 454

  Fly   601 PGNLIYTILPTQSPQETFGCFIVGGATTSAFSQAEVNVGKVSYLY-NSTTAESFSYELQLQVSDG 664
            ....:.|:...|     .|...:.|.....|:.|::..|.|.|.: :|.:.:.|   :..::.||
Human   455 GAVRLVTVGGLQ-----HGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDF---VVFRIFDG 511

  Fly   665 IETSETVYLPVSVHPLELR---LVNNTGL-------IMIHKSSLPISTANLSIGTNAVDDHIDIR 719
            ..:....: |::|.|.:..   |:.|..:       |:|..|.|..|..:.|      ||:  |.
Human   512 HHSIRHKF-PINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDAS------DDY--IF 567

  Fly   720 YDIVKAPQ-----------------HGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYLHSSDFPW 767
            ::|.|.||                 ||.|||           |.|:      |.|.|.|.....:
Human   568 FNITKPPQAGEIMKKPGPGLIGYPVHGFLQR-----------DLFN------GIIYYRHFGGEIF 615

  Fly   768 QDEFKFI-----ASFGFVTTQTFDFRITFTRLRITSTRPSQISINGSREILLTSDVLSYET---- 823
            :|.|:|:     ........|.....||....::....|..     ||.:::....::|.|    
Human   616 EDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGV-----SRHLVVKETEVAYITKKQL 675

  Fly   824 --TPIGSFARSVIYKITKPTRY---------GGIYVEGS------RKAAKKLDSFTQQDIEKRRI 871
              ....|:.|.::|.||.|..:         |.:::..|      ...|.:|.||||..:...::
Human   676 HFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKV 740

  Fly   872 RYQTHHTSYSSFSDHLEFVVSVAE---------CDDVAGVLEINYRPPDELINKLGYQNHEPLQV 927
            .|.............::|..||:.         |.::. :|.::.:.|:...|        ||:|
Human   741 AYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNIT-ILPVDNQVPEAFTN--------PLKV 796

  Fly   928 QEGERALITKNHFGIRFNIYESLQFQVSLS----PEHGVICKYDEQTGLTTPVE---MFTLEQLF 985
            .||.:::|:..|  |..:..::....:.||    |.||.:    |..|.  |:.   .|:...|.
Human   797 TEGGQSIISTEH--ILISDADTKLDNIDLSLRELPLHGRV----ELNGF--PLNSGGTFSWGDLH 853

  Fly   986 RNDIYYCHDDTESTRDTFELLILSGDETDLQFVSNMEVHIKLVNDNEPYRTA-IERVFHVVRNGI 1049
            ...:.|.||.||..:|...|.:..|..: .:||.::||.  .|||..|...| :..|.:....|.
Human   854 TLKVRYQHDGTEVLQDDLLLEVTDGTNS-AEFVLHVEVF--PVNDEPPVLKADLMPVMNCSEGGE 915

  Fly  1050 RTLNPTVLQYLDA-DVNTNHTDIHYIHV-SSTNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADS 1112
            ..:..   :|:.| ||::::..:.::.. ...:|...::|..:|.|:|.|:.:..:.::|||.:.
Human   916 VVITS---EYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEI 977

  Fly  1113 G------TASFIVTDREHEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMK 1171
            |      |.:.:|:|.|           :.|||:....|.                         
Human   978 GLMPCFDTITLVVSDGE-----------AGPFVNGCCYNG------------------------- 1006

  Fly  1172 LDEIYYEVIKPPSYGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIASMD 1236
                       |:..:.::.|                                            
Human  1007 -----------PNPSVPLHAS-------------------------------------------- 1016

  Fly  1237 KVRYRVHIKNITAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDI 1301
               :.|:..|||        :||... :|..:.......|:|..|..::.:.|....|:.:..|:
Human  1017 ---FPVYDLNIT--------VYPVDN-QPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDL 1069

  Fly  1302 TFLVTSSPMHGYLE--MQSMSFD--------DEYNCKVFDQSSVNTEKMFYIQA---GVNQSTDY 1353
            .|::.|.|..||||  :.|:.|:        |.:..|..:...:|     |:|:   .:..:.|.
Human  1070 EFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHIN-----YVQSRHLRIEPTADQ 1129

  Fly  1354 FVFDVTNGITWLRQLMIKIVIIPEK----LYMHSNIISVVEGKTVQLNPTDIQPYSEYYRGKILE 1414
            |...||:|.....::...|:|.|..    .::..| |:|.||:..:|:.:.|...........|.
Human  1130 FTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQN-ITVCEGQMKELDSSIISAVDLDIPQDALL 1193

  Fly  1415 YIVTITPSSGHVL-AGNSK-----------------VKRFTQKQLEQG-SIQYVHNGSENATDSI 1460
            :.:|..|..|.:: .|.||                 |..|:.:.|:.| .:.|:|:.||:..|..
Human  1194 FSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDF 1258

  Fly  1461 TLVAMARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTF 1525
            | :.::..|..:...:...|:.||||:||:.....:.:..|...:|.:..|.|.|.|:|.|.:.:
Human  1259 T-IQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYY 1322

  Fly  1526 VVNHI-YGGYLARK-------SAPHQKIEHFTQAQINLEEIYFMH----DSNSRRNELSFVVTDG 1578
            |...: ..|.|..|       .:|..|.   ||.:::|..:.:.|    ||.: ::..:|.:.||
Human  1323 VFERLPQNGQLQLKIGRDWVPLSPGMKC---TQEEVDLNLLRYTHTGAMDSQN-QDSFTFYLWDG 1383

  Fly  1579 LFNTTTQMLNIEIKPIE-----ILAEHNENLHVFPLTKKQILRDYLHFKC------SDEEREIRY 1632
            ...:......|.||.:|     ||.:        ||...:..|.:|....      :|:..|:.|
Human  1384 NNRSPALDCQITIKDMEKGDIVILTK--------PLVVSKGDRGFLTTTTLLAVDGTDKPEELLY 1440

  Fly  1633 NITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEHTAVIMEFRTNDSFYFDVVAERSDR 1697
            .||.||..|:|  |::..... .::.|:|.||....:.|.|.:.:..  ::|.|.|.:    |:.
Human  1441 VITSPPRYGQI--EYVHYPGV-PITNFSQMDVVGQTVCYVHKSKVTV--SSDRFRFII----SNG 1496

  Fly  1698 LLNQKFNIEISVSSGGLLRFLPVNKLNVDEGGSVPIKLDFSKILEYLKTKAGINNPEL------- 1755
            |..:....||::.:  :.|.|||...|              |.|...:...|:.:|:|       
Human  1497 LRTEHGVFEITLET--VDRALPVVTRN--------------KGLRLAQGAVGLLSPDLLQLTDPD 1545

  Fly  1756 -------FIEAIQKPTHGNI---GLG---HEFKHMQRYHPSDFFTKKVYYIHDHSDTLED--TIL 1805
                   |: .:|.|.||.:   |.|   |.|..      .|..:|.|.|.|...|:..|  |.:
Human  1546 TPAENLTFL-LVQLPQHGQLYLWGTGLLQHNFTQ------QDVDSKNVAYRHSGGDSQTDCFTFM 1603

  Fly  1806 MSVYLTQGNIFLCNLTI---PVSINPINDQPFHLVTHLPQMTVVEGENRT-----------ITRN 1856
            .:....||  |:.|..:   ||......||   |....|::|::...::.           ||..
Human  1604 ATDGTNQG--FIVNGRVWEEPVLFTIQVDQ---LDKTAPRITLLHSPSQVGLLKNGCYGIYITSR 1663

  Fly  1857 DLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMP- 1920
            .|...|.||..::||:.::.||..|.|...|...      ....:|:|.|:|:..|:|:.  .| 
Human  1664 VLKASDPDTEDDQIIFKILQGPKHGHLENTTTGE------FIHEKFSQKDLNSKTILYII--NPS 1720

  Fly  1921 ---QSTTFCFTVSDGQSNPAY-EIFTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLDHIGVSTNV 1981
               .|.|..|.:.|...|.|. :|..:|..  |::.|  |...:|.:.....|:.:...|.|.:.
Human  1721 LEVNSDTVEFQIMDPTGNSATPQILELKWS--HIEWS--QTEYEVCENVGLLPLEIIRRGYSMDS 1781

  Fly  1982 HMERLSYNVTNSPL---FGIIVYKHQPTLRFTQQQLETSQISYMQTDLNRSNDSFQVSAYVPGTN 2043
            ....:..|..::.:   |.:|..|                  .:|.|...|...:.::....|  
Human  1782 AFVGIKVNQVSAAVGKDFTVIPSK------------------LIQFDPGMSTKMWNIAITYDG-- 1826

  Fly  2044 YVAQVDVVMEVEPVIQINDIV-------MKEAESSGGKIKLITSLDNDN------------PLSL 2089
             :.:.|.|.||.....:|.::       :|..:|.||:.....|.:...            |...
Human  1827 -LEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGS 1890

  Fly  2090 KLNKFNPKFVITR--MPSTGQIRKIIR--------STGLTT-------DGQSDRSTNIFSYKELR 2137
            ..:..:..|.:.|  :||:.|: .:||        ||.|:.       :|::.|.::::     |
Human  1891 SSSTTSGSFHLERRPLPSSMQL-AVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVY-----R 1949

  Fly  2138 SGVVYFVPHESVEETEADHDSF---DYQLLIKTVQPAQATVSI---EYRSRVEETETVH 2190
            :|......:..:...:.:.|||   ..:..:..:...|.|:.:   ....:||.|...|
Human  1950 NGTDIIYNYHGIVSLKLEDDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSH 2008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_609881.3 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058
Cadherin_3 <445..535 CDD:465048 13/62 (21%)
Cadherin_3 552..664 CDD:465048 22/113 (19%)
Cadherin_3 667..773 CDD:465048 31/132 (23%)
Cadherin_3 781..892 CDD:465048 24/131 (18%)
Cadherin_3 921..1005 CDD:465048 24/90 (27%)
Cadherin_3 1025..1121 CDD:465048 23/104 (22%)
Cadherin_3 <1149..1230 CDD:465048 2/80 (3%)
Cadherin_3 1264..1361 CDD:465048 25/109 (23%)
Cadherin_3 1369..1464 CDD:465048 27/117 (23%)
Cadherin_3 1470..1578 CDD:465048 28/119 (24%)
Cadherin_3 1821..1932 CDD:465048 30/128 (23%)
FREM1XP_016869805.1 Frem_N 29..269 CDD:466034
Cadherin_3 <324..400 CDD:465048 13/64 (20%)
Cadherin_3 405..511 CDD:465048 23/123 (19%)
Cadherin_3 513..625 CDD:465048 32/137 (23%)
Cadherin_3 633..764 CDD:465048 26/135 (19%)
Cadherin_3 775..878 CDD:465048 28/119 (24%)
Cadherin_3 880..993 CDD:465048 27/118 (23%)
Cadherin_3 1016..1137 CDD:465048 32/181 (18%)
Cadherin_3 1140..1265 CDD:465048 27/126 (21%)
Cadherin_3 1267..1383 CDD:465048 28/119 (24%)
Cadherin_3 1393..1496 CDD:465048 30/119 (25%)
Cadherin_3 1498..1607 CDD:465048 29/131 (22%)
Cadherin_3 1622..1734 CDD:465048 30/122 (25%)
Calx-beta 1755..1838 CDD:413355 18/105 (17%)
CLECT 2062..2184 CDD:214480
Blue background indicates that the domain is not in the aligned region.

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