DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kon and CSPG4

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001888.2 Gene:CSPG4 / 1464 HGNCID:2466 Length:2322 Species:Homo sapiens


Alignment Length:2560 Identity:615/2560 - (24%)
Similarity:1054/2560 - (41%) Gaps:443/2560 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LAWLAILQLQTVAAMKVSLFGDGYVSMPLQEAKMSTNIRVKFRTRQENAFLFLAAGRTDYCLLRL 78
            ||....|.:....|...|.||:.::.:|:..|....:::::|.|.|..|.|.||||..|:.||:|
Human    14 LALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQL 78

  Fly    79 ESGLISFSYKIERDVVQLRSPKKQKLNDLEWHDVAVQRFENNITLQVDGYI-MRKQLPGDLAALN 142
            .||.:.....:.::.::|::|.:..|:|...|.|.:...|...||.|||:: ....:||  |.|.
Human    79 YSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPG--APLE 141

  Fly   143 IHFGTFLGGVGDFTAEFLDDVI-GFRGCISDVFYNNINIIKRAKDRTSHTTSTGVAWTCSTEFEG 206
            :.:|.|:||.|.....:|.... ..|||:.....|..::::        ..:..|...|:.||..
Human   142 VPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSLLR--------PLTPDVHEGCAEEFSA 198

  Fly   207 SIQDSISFMRNDSYSLMMKESYAMGETLSLQFRTMAS----AGVIFFNGGY--DFILLEIEDQHL 265
            |  |.::...:..:||....::...:..:|:| |:.:    |.:.|..||.  |||.::|.:.||
Human   199 S--DDVALGFSGPHSLAAFPAWGTQDEGTLEF-TLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHL 260

  Fly   266 KVTFNKAGSLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLEK-- 328
            :....|....|....:..::||:.|.|.:..||...|:|:|...     ||.:.......||.  
Human   261 RAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYP-----THTSNRGVLSYLEPRG 320

  Fly   329 SVFFGGVQEEMRRRLISKGLRI----NEISFKGCMRDILVNDLPLGFAEMTISRSLALNCLWKYP 389
            |:..||:..|..|.|....|.:    ...|..|||.|:.||....|..|..::|::|..|  :..
Human   321 SLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGC--RLE 383

  Fly   390 CVEYNPCLKSGICSQHGVDGFICYCDQSYCIKADFQGPFKIFTETSPE----------------- 437
            ..||.                    |.:|       |.::.|:..:||                 
Human   384 EEEYE--------------------DDAY-------GHYEAFSTLAPEAWPAMELPEPCVPEPGL 421

  Fly   438 -------LELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQL-LQY 494
                   .:||.:||:.:.|||||:|....:...|||.. ..|.:..::|.|....::|:| |..
Human   422 PPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLME-AELRKSQVLFSVTRGARHGELELDI 485

  Fly   495 SAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHAN 559
            ...:|    .:.|.|:|:...|.:::|:|.|:.:|...|::.:...| .:|..:.....:||...
Human   486 PGAQA----RKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARV-PMPSCLRRGQTYLLPIQ 545

  Fly   560 ITPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQS--PQETFGCFI 622
            :.|:||||.:......::.::|..::.|..::|...||||....|.:.:|.|.|  |.|...   
Human   546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRD--- 607

  Fly   623 VGGATTSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLP-VSVHPLELRLVN 686
            ..|...:.||..|:..|.:.|::....|:    :|..:||||::.|....|. |::.| .:::..
Human   608 QPGEPATEFSCRELEAGSLVYVHRGGPAQ----DLTFRVSDGLQASPPATLKVVAIRP-AIQIHR 667

  Fly   687 NTGLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDW----- 746
            :|||.:...|::||..||||:.||||...:.:.:.:..|.|.|.||  :|..|.....:|     
Human   668 STGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ--KQGAGGVEGAEWWATQA 730

  Fly   747 FSDSQLLLGHIRYLHSSDFPWQDEFKFIASF------GFVTTQTFDFRITFTRLRITSTRPSQIS 805
            |....:..|.:||| |:| |....:..:.:.      |........|.:|..|..:...|...:.
Human   731 FHQRDVEQGRVRYL-STD-PQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLH 793

  Fly   806 INGSREILLTSDVLSYETTPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRR 870
            ...:::..||:..|.......|....:..|::.:..|.|.:.::|:|.:..:  .|||.||:..|
Human   794 TQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQ--GFTQDDIQAGR 856

  Fly   871 IRYQTHHTSYSSFSDHLEFVVSVAECDDVAGVLEINY-RPPDE--LINKLGYQNHEPLQVQEGER 932
            :.|.....:..:..|...|.|:............|:. ..||.  |.|.|       |.|.||..
Human   857 VTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLTNVL-------LVVPEGGE 914

  Fly   933 ALITKNHFGIRFNIYESLQFQVSLSPEHGVICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTE 997
            .:::.:|..::.....|..::|...|.||.:.....| ..||.|..||.|.|.|..:.|.|||:|
Human   915 GVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQ-DKTTMVTSFTNEDLLRGRLVYQHDDSE 978

  Fly   998 STRDTFELLIL-----SGDETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVL 1057
            :|.|....:..     |||....:......|.|:.|||:.|.:| |.|:|||.|.|.|.|....:
Human   979 TTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQT-ISRIFHVARGGRRLLTTDDV 1042

  Fly  1058 QYLDAD-------VNTNHTDIHY---IHVSSTNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADS 1112
            .:.|||       :.....|:.:   :.|.......|:       |||:|:..||::|.|:|||.
Human  1043 AFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR-------FTQEDLRKRRVLFVHSGADR 1100

  Fly  1113 GTASFIVTDREHEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKL-DEIY 1176
            |.....|:|.:|:...|||::||:|::.:...::.:|.:|....:......|:||||::. ||::
Human  1101 GWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVH 1165

  Fly  1177 YEVIKPPSYGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVY-WNTEIASMDKVRY 1240
            |.|...|.:|.|:   ||  |:..|.            |:..|:....::| .|..::..|.:.:
Human  1166 YHVTAGPRWGQLV---RA--GQPATA------------FSQQDLLDGAVLYSHNGSLSPRDTMAF 1213

  Fly  1241 RVHIKNITAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLV 1305
            .|....:..:..:...|.......||::.::..:||.:..:..|.||.||.....:.|.||.|.|
Human  1214 SVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSV 1278

  Fly  1306 TSSPMHGYLEMQSM--------SFDDEYNCKVFDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGI 1362
            .|.|..|||.|.|.        |.|.   .:.|.|.:|:|.::.|:.:.....:|.|..||.:|:
Human  1279 KSPPSAGYLVMVSRGALADEPPSLDP---VQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGL 1340

  Fly  1363 -TWLRQLMIKIVIIPEKLYMHSNIISVVEGKTVQLNPTDIQ---PYSEYYRGKILEYIVTITPSS 1423
             ..|..:::::.::|..:.:.:...||.||.::.|.|..::   ||.....|..|:  |...|..
Human  1341 GAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ--VLEPPQH 1403

  Fly  1424 GHVLAGNSKVKR----FTQKQLEQGSIQYVHNGSENATDSITLVAMA--RNKESVPFELEFAVVQ 1482
            |.:...:....|    |:.:.:|:..|:|||:|||..|||..|:|.|  .:::|.|......|:.
Human  1404 GALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVLMANASEMDRQSHPVAFTVTVLP 1468

  Fly  1483 VNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIEH 1547
            |||:.|::.||||||:|.|....|....|.:.|.|:..|:|.:.:.....|.:..:.||..::..
Human  1469 VNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRS 1533

  Fly  1548 FTQAQINLEEIYFMH----DSNSRRNELSFVVTDG-------LFNTTTQMLNIEIKPIEILAEHN 1601
            |||||::...:.|.|    |...|     |.::||       .|..|.|      |.:.:..:.:
Human  1534 FTQAQLDGGLVLFSHRGTLDGGFR-----FRLSDGEHTSPGHFFRVTAQ------KQVLLSLKGS 1587

  Fly  1602 ENLHVFPLTKKQILRDYLHFKCS--DEEREIRYNITVPPSLGRIVNEFIDNGFTKE-VSEFTQND 1663
            :.|.|.|.:.:.:....|....|  .:.:.:.|.:...|.|||:.:...|:  |.| :..|||.:
Human  1588 QTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDS--TGEALVNFTQAE 1650

  Fly  1664 VDNGHIFYEHTAV---------IMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLLRFLP 1719
            |..|:|.|||...         .:|.:.:.....||.|           .:.::||........|
Human  1651 VYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAA-----------TLAVAVSFEAACPQRP 1704

  Fly  1720 ----VNK-LNVDEGGSVPI---KLDFSKILEYLKTKAGINNP-----ELFIEAIQKPTHGNIGLG 1771
                .|| |.|.||....|   .||.|.:|      |.:.:|     ::..:..|.|:.|.:.:.
Human  1705 SHLWKNKGLWVPEGQRARITVAALDASNLL------ASVPSPQRSEHDVLFQVTQFPSRGQLLVS 1763

  Fly  1772 HEFKHMQRYH--PSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCNLTIP----------- 1823
            .|..|..:.|  .|.....::.|.|....|.:|          |..|..:|..|           
Human  1764 EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQD----------GFHFRAHLQGPAGASVAGPQTS 1818

  Fly  1824 ----VSINPINDQPFHLVTHLPQMTVVEGENRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLR 1884
                :::..:|::|......:| :.:..|....|:|..|...|.|:.|.||.|:|...|..|.|.
Human  1819 EAFAITVRDVNERPPQPQASVP-LRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLS 1882

  Fly  1885 KITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQSTTFCFTVSDGQSNPAYEIFTIKIDSIH 1949
            .:.....|      ..:|||||:::.|:.:|..|...:..|..::|||.|.|.  ..::.:|   
Human  1883 LVGGGLGP------VTRFTQADVDSGRLAFVANGSSVAGIFQLSMSDGASPPL--PMSLAVD--- 1936

  Fly  1950 LQPSA----MQAPVKVQQGATTAPMRLDHIGVSTNVHMERLSYNVTNSPLFGIIVYKHQPTLRFT 2010
            :.|||    ::||::|.|....:.:....:.|.::......:|.:...|.:|.::...:||..|:
Human  1937 ILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQGPQYGHLLVGGRPTSAFS 2001

  Fly  2011 QQQLETSQISYMQTDLNRSNDSFQVSAYVPGTNYVAQVDVVMEVEPVIQINDIVMKEAESSGGKI 2075
            |.|::..::.:..|:.:.|:|.|:|.|...|.|..|.|:|.:..     :..:........|..:
Human  2002 QFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVNVTVRA-----LLHVWAGGPWPQGATL 2061

  Fly  2076 KLITSLDNDNPLSLKLNKFNPKFVITRMPSTGQIRKIIRSTGLTTDGQSDRSTNIFSYKELRSGV 2140
            :|..::.:...|:.:.... |:|.:...|..|::.::.|:   .|:....:....|:.::|..|.
Human  2062 RLDPTVLDAGELANRTGSV-PRFRLLEGPRHGRVVRVPRA---RTEPGGSQLVEQFTQQDLEDGR 2122

  Fly  2141 VYF-VPHESVEETEADHDSFDYQLLIKTVQPAQAT------------------VSIEYRSRVE-- 2184
            :.. |............||...:|..:.|.||.|:                  :|:...:|.|  
Human  2123 LGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDFATEPYNAARPYSVALLSVPEAARTEAG 2187

  Fly  2185 ----ETETVHLG----------SAGLSINYLAIGCAIFIVLICLLIVLLIL---------KIRKL 2226
                .|.|...|          :.|..:::|.......|:.:||:::||.|         |..|.
Human  2188 KPESSTPTGEPGPMASSPEPAVAKGGFLSFLEANMFSVIIPMCLVLLLLALILPLLFYLRKRNKT 2252

  Fly  2227 RKHKADISKDQPPALPCPPDLTSVSPQHHLHHHHGHHYASSEADSVPATGNSTPLPGFSNIPHCK 2291
            .||...:             ||                      :.|..|.:.....|..:...:
Human  2253 GKHDVQV-------------LT----------------------AKPRNGLAGDTETFRKVEPGQ 2282

  Fly  2292 IIPVESYKHEYPDYDPDEEETDDQCDPQQMMLPQRYNPYHMEHDAWSSSCDMANDFAGYASVPQS 2356
            .||:.:...:.|       ....|.||:.:.                           :...|  
Human  2283 AIPLTAVPGQGP-------PPGGQPDPELLQ---------------------------FCRTP-- 2311

  Fly  2357 ISGSVSSPPSAPPTNPLLRRNQYWV 2381
                          ||.|:..||||
Human  2312 --------------NPALKNGQYWV 2322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058 45/147 (31%)
LamG 211..365 CDD:238058 42/165 (25%)
Cadherin_3 507..664 CDD:292802 41/158 (26%)
Cadherin_3 631..776 CDD:292802 45/150 (30%)
Cadherin_3 747..892 CDD:292802 31/150 (21%)
Cadherin_3 861..1005 CDD:292802 42/146 (29%)
Cadherin_3 979..1121 CDD:292802 50/156 (32%)
Cadherin_3 1093..1242 CDD:292802 44/150 (29%)
Cadherin_3 <1264..1361 CDD:292802 32/104 (31%)
Cadherin_3 1330..1464 CDD:292802 39/141 (28%)
Cadherin_3 1436..1578 CDD:292802 49/147 (33%)
Cadherin_3 1789..1932 CDD:292802 36/157 (23%)
Cadherin_3 2009..2163 CDD:292802 29/154 (19%)
CSPG4NP_001888.2 LamG 29..176 CDD:238058 45/148 (30%)
Globular or compact configuration stabilized by disulfide bonds 30..639 167/668 (25%)
Neurite growth inhibition. /evidence=ECO:0000250 30..639 167/668 (25%)
LamG 203..361 CDD:238058 42/163 (26%)
Cadherin_3 494..645 CDD:292802 41/158 (26%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201, ECO:0000269|PubMed:12220645 553..645 24/98 (24%)
Interaction with COL6A2. /evidence=ECO:0000250 574..1040 132/488 (27%)
Cadherin_3 616..743 CDD:292802 39/133 (29%)
Interaction with COL5A1. /evidence=ECO:0000250 631..1446 228/863 (26%)
Cadherin_3 731..878 CDD:292802 31/150 (21%)
Cadherin_3 847..989 CDD:292802 42/149 (28%)
Cadherin_3 960..1110 CDD:292802 50/157 (32%)
Cadherin_3 1187..1336 CDD:292802 37/151 (25%)
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201, ECO:0000269|PubMed:12220645 1356..1449 27/94 (29%)
Cadherin_3 1420..1563 CDD:292802 49/147 (33%)
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201, ECO:0000269|PubMed:12220645 1473..1563 28/94 (30%)
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201, ECO:0000269|PubMed:12220645 1581..1679 23/99 (23%)
Neurite growth inhibition. /evidence=ECO:0000250 1586..2221 145/684 (21%)
Cysteine-containing 1587..2221 145/683 (21%)
Cadherin_3 1646..1802 CDD:292802 42/182 (23%)
Cadherin_3 1774..1924 CDD:292802 37/166 (22%)
Cadherin_3 2000..2123 CDD:292802 26/131 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2182..2206 5/23 (22%)
PDZ-binding 2320..2322 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159688
Domainoid 1 1.000 61 1.000 Domainoid score I10515
eggNOG 1 0.900 - - E1_KOG3597
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 555 1.000 Inparanoid score I1113
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46545
OrthoDB 1 1.010 - - D119072at33208
OrthoFinder 1 1.000 - - FOG0003479
OrthoInspector 1 1.000 - - oto91048
orthoMCL 1 0.900 - - OOG6_106870
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4086
SonicParanoid 1 1.000 - - X2369
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.700

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