DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kon and LOC110440062

DIOPT Version :9

Sequence 1:	NP_001260539.1	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster
Sequence 2:	XP_021334936.1	Gene:	LOC110440062 / 110440062	-ID:	-	Length:	1341	Species:	Danio rerio

Alignment Length:	1424	Identity:	409/1424 - (28%)
Similarity:	663/1424 - (46%)	Gaps:	159/1424 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FGW---LWLAWLAILQLQTVAAMKVSLFGDGYVSMPLQEAKMSTNIRVKFRTRQENAFLFLAAGR 70
            |.|   |.|.|.|:   ||..|   |.:|||:|.:...|....|:|.|:|||...:..||||||.
Zfish    11 FLWRVFLLLTWTAV---QTFGA---SFYGDGFVHLKTVELSSQTSIHVRFRTSGSSGLLFLAAGE 69

  Fly    71 TDYCLLRLESGLISFSYKIERDVVQLRSPKKQKLNDLEWHDVAVQRFENNITLQVD-GYIMRKQL 134
            .|:..:.|.||.|....:.......:||.|...||||.||.|.:|....||||.|| ..:...::
Zfish    70 KDFLWVGLHSGRIEVRIEFGSGEQTVRSEKGIPLNDLTWHAVELQHDHENITLTVDKNSVTTVRM 134

  Fly   135 PGDLAALNIHFGTFLGGVGDFTAEFL---DDVIGFRGCISDVFYNNINIIKRAKDRTSHTTSTGV 196
            ||....|::..|.|:|||||....:|   |...|||||:.:|.:|..|::...:..:.:.....|
Zfish   135 PGPDLELDVQDGLFVGGVGDLEKSYLSADDSSFGFRGCVDEVLFNEHNLLSSLRPYSGYKMIHEV 199

  Fly   197 AWTCSTEFEGSIQDSISFMRNDSY-SLMMKESYAMGETLSLQFRTMASAGVIFFN--GGYDFILL 258
            :..||.||..::.:||||..:.:| ||.|.:....| ....:.||:.|.|:..::  |..|:|.|
Zfish   200 SLGCSPEFSATVNNSISFFSSKAYMSLPMWDVPQEG-VFECELRTVYSEGIFLYSSAGQGDYIAL 263

  Fly   259 EIEDQHLKVTFNKAGS----LVQFMTNEHISDGKWH--RVFLRYNAAIAELSLDDATSGYRGTHA 317
            ||:..|| |...|.|:    |...|.   ::||.||  |::|........|.|:...|.: |.:|
Zfish   264 EIQKGHL-VAILKIGATKTVLRSLMV---VNDGAWHILRLYLSPLNLQFTLGLEMHNSSF-GINA 323

  Fly   318 NETKASINLEKSVFFGGVQ----EEMRRR-LISK-GLRINEISFKGCMRDILVNDLPLGFAEMTI 376
                :::.....:|.|||.    .::|:. |:|. |.||...|||||:|:|.||...:|..:..:
Zfish   324 ----SALQFIGPLFLGGVDANTYTDVRKNGLLSMLGKRIAGGSFKGCLRNIRVNYQRMGLPKALV 384

  Fly   377 SRSLALNCLWKYPCVEYNPCLKS----GICSQHGVDGFICYCDQSYCIKADFQGPFKIFTETSPE 437
            ::.:::.|   .|...:.|...|    .:.|::                         :|:...|
Zfish   385 TKDISVGC---EPEKLFGPTTASPSTNALYSEN-------------------------YTDVPAE 421

  Fly   438 LE---LLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQL-LQYSAEK 498
            |:   .|.:..:::|||..|.|....|.|.||.|:. .:.:..|:|.:..||.:||| |...::
Zfish   422 LDKRNFLLLKDLEVLEGSRAPLESKHIKINLDFRKL-GIRQSQIMFRIEEQPVHGQLRLDVDSD- 484

  Fly   499 AIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGK--HRFLLHANIT 561
               :...||:::||...::.|||.|.|:..|.....: :.....::|..:.|.  |||  :.:||
Zfish   485 ---LGENTFSMLDLWHKRVMYVHGGSEDLFDFFMFSI-LTSSKKEVPSCLKGNRLHRF--NISIT 543

  Fly   562 PINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFIVG-- 624
            |:||.|:|.|....:..::|...|.|..|:..:.|||:...:|.:|:|         |..||.
Zfish   544 PVNDAPELSLPEGSLFIMVEHSRRHLSTDVLRVIDPDTNSTDLKFTVL---------GNLIVNSG 599

  Fly   625 --------GATTSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLE 681
                    |...::||.:::..|||:|::....    :..:.|:||||.:.|.||...:...|||
Zfish   600 FIEIDEHPGKAVTSFSLSDLEEGKVNYVHKGVK----NSRMALRVSDGDKVSNTVVFRIIAVPLE 660

  Fly   682 LRLVNNTGLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDW 746
            .:|.||||:.:|...:..||..||:|..|.....:||||||...|.:|.||||.. .|.|.....
Zfish   661 YKLTNNTGVEVIQGDATFISNKNLAIQVNVPKQAVDIRYDITVPPVYGELQRLHS-SGQWKQTST 724

  Fly   747 FSDSQLLLGHIRYLHSSDFPWQ----DEFKFIASFGFVTTQTFDF--RITFTRLRITSTRPSQIS 805
            |:...|....:|||.:.....|    |.||:.|:.|.|.|..|.|  |:.:.|.|||.   :::.
Zfish   725 FTQKLLEKERLRYLSTFHGTQQSNITDSFKYKATLGSVITDEFLFLIRVRWIRYRITK---NKVE 786

  Fly   806 INGSREILLTSDVLSYETTPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRR 870
            |.|.:::.|:.......|.........:..::....|.|.:.::  .|..|:..:|:|..|.|::
Zfish   787 IEGKQKVTLSPQEFHVVTKGARLTENDLHIRLLTLPRKGHLLLD--NKILKRNSTFSQDCIAKQK 849

  Fly   871 IRYQTHHTSYSSFSDHLEFVVSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGERALI 935
            ::|:....::....|...|.|.....  ::|:.|.......: |:.:...|| .|.|.|||..:|
Zfish   850 LQYELLEKAHDDARDMFHFQVFSKYA--MSGIHEFKISIKAD-IHDIILSNH-GLSVLEGESKVI 910

  Fly   936 TKNHFGIRFNIYESLQFQVSLSPEHGVICKYD--EQTGLTTPVEMFTLEQLFRNDIYYCHDDTES 998
            |.............:.:.|:..|:||::.|.:  ..:.....:..||.:.:....|.|.|||:|:
Zfish   911 TNTMLFSETASSRMVHYTVTNIPKHGILQKINLSNSSSRNDTITEFTNQDILDERIMYVHDDSET 975

  Fly   999 TRDTFELLILSGD--ETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLD 1061
            |:|.|..:...|.  ...|.......:.|:||||.:|.| .:::|||||.|..|.|....|.|.|
Zfish   976 TQDAFRFVASFGSLKNKTLGTEGVFNISIQLVNDEKPVR-VVDKVFHVVHNSQRLLTLEDLCYHD 1039

  Fly  1062 ADVNTNHTDIHYIHVSSTNGAFY---KSGHYIDSFTQDDIANRRIMFQHTGADSGTASFIVTDRE 1123
            .|.:.:..|:.|.......|...   .:.|.:..|.|.|:..:|::|.|.||..|.....::|.:
Zfish  1040 PDTDFDDKDLLYTRRKIPTGELVLVNDTTHKLYQFHQRDLEEKRVLFIHKGASYGRFILFISDSK 1104

  Fly  1124 HEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKLD-EIYYEVIKPPSYGI 1187
            |..:.:||:.|.||||.:......:||:|:..:|...:|.:.||:|::.| |:.:||..|||:|
Zfish  1105 HYTSTVLEVSAQDPFVEVGNNTGLLVQKGQAAILGVANFSISTNMDVRHDEEVVFEVFLPPSHG- 1168

  Fly  1188 LMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYW--NTEIASMDKVRYRVHIKNITAE 1250
                          |:|  .|....:.||..|::.:.::|.  :.||.. |.......:|.:..:
Zfish  1169 --------------TLY--CNGIKTNTFTQHDVKMDHVIYHHDDNEILE-DFFNITSKVKGLHLD 1216

  Fly  1251 GEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYLE 1315
            ..|..::|..::.:|..|..|:.:.|:|...|.|:::||:|:|.:..|.:..:.|..:|.||:|.
Zfish  1217 VSVNIKVYLESHQQPPTVIHNNPILVDEGKPVKITKEVLQVIHEDNKPYEFLYTVKVAPAHGFLR 1281

  Fly  1316 MQSMSFDDEYN------CKVFDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGITWLRQL 1368
            : ||..:..|.      .:.|.|..:|...:.|:|.......|.|..||||||..||::
Zfish  1282 I-SMVKESHYRGSQESPIESFSQGDINEGHVQYVQNEKGYVNDSFALDVTNGILTLREV 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kon	NP_001260539.1	LamG	30..176	CDD:238058	58/149 (39%)
		LamG	211..365	CDD:238058	54/168 (32%)
		Cadherin_3	507..664	CDD:292802	45/168 (27%)
		Cadherin_3	631..776	CDD:292802	52/148 (35%)
		Cadherin_3	747..892	CDD:292802	35/150 (23%)
		Cadherin_3	861..1005	CDD:292802	36/145 (25%)
		Cadherin_3	979..1121	CDD:292802	45/146 (31%)
		Cadherin_3	1093..1242	CDD:292802	44/151 (29%)
		Cadherin_3	<1264..1361	CDD:292802	30/102 (29%)
		Cadherin_3	1330..1464	CDD:292802	15/39 (38%)
		Cadherin_3	1436..1578	CDD:292802
		Cadherin_3	1789..1932	CDD:292802
		Cadherin_3	2009..2163	CDD:292802
LOC110440062	XP_021334936.1	LamG	28..179	CDD:238058	59/153 (39%)
		LamG	217..373	CDD:238058	51/165 (31%)
		Cadherin_3	<433..518	CDD:318425	28/89 (31%)
		Cadherin_3	538..643	CDD:318425	32/119 (27%)
		Cadherin_3	647..758	CDD:318425	41/111 (37%)
		Cadherin_3	877..985	CDD:318425	28/109 (26%)
		Cadherin_3	998..1102	CDD:318425	32/104 (31%)
		Cadherin_3	1109..1207	CDD:318425	33/115 (29%)
		Cadherin_3	1230..1332	CDD:318425	30/102 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119072at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010