DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and cspg4b

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:XP_002941158.3 Gene:cspg4b / 100145673 XenbaseID:XB-GENE-5893460 Length:2393 Species:Xenopus tropicalis


Alignment Length:2578 Identity:679/2578 - (26%)
Similarity:1143/2578 - (44%) Gaps:411/2578 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LAIL----QLQTVAAMKVSLFGDGYVSMPLQEAKMSTNIRVKFRTRQENAFLFLAAGRTDYCLLR 77
            ||::    :|.|:||   |.:|:.:|.:...|:...:.:.:||||.:.:..||||||:..|.||.
 Frog    14 LAVVVSSSRLHTLAA---SFYGESFVELKTAESFSKSTLHLKFRTSKPDGLLFLAAGKKQYSLLE 75

  Fly    78 LESGLISFSYKIE-RDVVQLRSPKK-QKLNDLEWHDVAVQRFENNITLQVDGYIMRK-QLPGDLA 139
            |.||.:  ..||: .:..|:..||. .:|:|||||.|.:.....::.|.||.:|... ::.|.|.
 Frog    76 LHSGHV--QGKIDFGEGEQILLPKNGPRLDDLEWHVVKLHHENADVVLSVDQHINSSLRVAGGLQ 138

  Fly   140 ALNIHFGTFLGGVGDFTAEFLDDVIG-FRGCISDVFYNNINIIKRAKD----RTSHTTSTGVAWT 199
            ..::|:|.::||..|....:...:.. ||||:.:|.:||..::...:.    :..|..|.|    
 Frog   139 EFSVHYGLYVGGFSDLDVSYAKILPNHFRGCLDEVVFNNQELLSSLRPYPGLKNVHEVSLG---- 199

  Fly   200 CSTEFEGSIQDSISFMRNDSYSLMMKESYAMGETLSLQFRTMASAGVIFFNGGY--DFILLEIED 262
            ||.||..|..|.:|...:.||.::...:...|.......::.|..|::.:..|.  :||.|||:|
 Frog   200 CSDEFFVSEDDPMSLFSSKSYVVLPPWTLEEGGVWECLLQSSAGKGLLLYQSGSVGNFISLEIQD 264

  Fly   263 QHLKVTFNKAGSLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLE 327
            ..||....|..||:|..|...|::.|||.:.|:.:|....|:||:.|          .|||:.|.
 Frog   265 YILKAHLRKGNSLIQLSTLNPITEHKWHHIKLKLSAKHFHLTLDEET----------VKASLTLN 319

  Fly   328 KSV-------FFGGVQEEMRRRLISK-----GLRINEISFKGCMRDILVNDLPLGFAEMTISRSL 380
            ..:       |.|||.:..|:.|||.     |.....:|||||:::|.||....|......::.:
 Frog   320 SKIAHLNGPLFVGGVNDAARKVLISSLGAVPGKHAKVVSFKGCIKNIKVNSKIYGLKNALATKDV 384

  Fly   381 ALNCLWKYPCVEYNPCLKSGICSQHGVDGFICYCDQSYCIKADFQGPFKIF-------TETSPEL 438
            :..|..:. .:..:|..|:               |:.:...|   .|....       |:.:.:.
 Frog   385 SPGCKTEM-LLTTSPVNKA---------------DEMHLNTA---APSTSLVTTTTAATQNNAKH 430

  Fly   439 ELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEKAIFVP 503
            ..:.::.:.:.|||.|.|....|.:.||.::. .:.:..|.|.:|..|:.|||       .|.||
 Frog   431 HFIVLNNLVVQEGGRAPLQSKHIKLNLDFKKL-GVRQSQITFKIVKYPQSGQL-------KIDVP 487

  Fly   504 CR----TFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHANITPIN 564
            ..    .|.::||...::.|:|:|.|..||:.|..:..... ::||..:.|..:.|....:||.|
 Frog   488 TTQNKDVFTMLDLWHGRITYIHDGSEGTNDNFTFTVTATSK-NEIPFYLDGTQQHLFSITVTPTN 551

  Fly   565 DPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFIVGGATT- 628
            |.|:|.|....:..::|..::.|..:|..:.|.|::|.||.:.:|...:..   ..|:|.|... 
 Frog   552 DAPELSLPEGNLFVLLENSKKRLPANLLKVSDVDTDPQNLNFVVLGNLNAD---AGFLVNGRDAG 613

  Fly   629 ---SAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLELRLVNNTGL 690
               |.||.:|:..|.:.|:::...    :..|.|:||||.:.|.||.|.:...||:.:||||||:
 Frog   614 KGISIFSYSELLDGNIFYVHHGVK----NSRLVLRVSDGDKVSNTVVLRILAVPLDYKLVNNTGI 674

  Fly   691 IMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLG 755
            ::....|..|.|:||.:.|||.:..::||||:::.|::|.:|| |.:...|.:.:.|:...|...
 Frog   675 VVTQGESTLILTSNLGVDTNAENQDMEIRYDVMELPKYGQIQR-RSVGNEWKSANSFTQRSLERE 738

  Fly   756 HIRYLHS----SDFPWQDEFKFIASFGFVTTQTFDFRITFTRLRITSTRPSQISINGSREILLTS 816
            .||||.:    .:....:.|||..:....:::.:.|.|:...|:.|..:.|.:::...:.:..|:
 Frog   739 RIRYLSTFNEVQEADGTEYFKFKVTIANKSSEEYLFPISVQWLKYTLVKHSALNVENRKPVTFTT 803

  Fly   817 DVLSYETTPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRRIRYQTHHTSYS 881
            |.:....|.|.:.|:.:.:|:....:.|.|.|  ::...|:.|.|:|.||...::.|:.......
 Frog   804 DNIFSVVTGISTAAKEIYFKVLSLPKKGRILV--NKNNLKENDMFSQVDITDLKVEYELTDQPRQ 866

  Fly   882 SFSDHLEFVVSVAECDDVAGVLEINYRPPDELINKLGYQNHEPLQVQEGERALITKNHFGIRFNI 946
            ...|...|.:.....:......:||.:..   :|.: :..:..|.:.||:..|||:|...::...
 Frog   867 DSRDFFSFSLFTKHAESKPHEFQINIKAD---LNSI-FLTNNGLSLAEGDSKLITRNELFVQTLN 927

  Fly   947 YESLQFQVSLSPEHGV--ICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTESTRDTFELLILS 1009
            .::..::|..||:||.  :..:.:.......:..|:.:.:....:.|.|||||:|.|:|.:|..|
 Frog   928 NKTFSYKVQKSPQHGKLRLINFSDSVLSNDNITAFSSQDILGERLMYAHDDTETTADSFTVLATS 992

  Fly  1010 ---------GDETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDADVN 1065
                     |::...:.:.|:.:.:|  ||.:|.| .::::|||||||.|.:....|.|.|:|.:
 Frog   993 LSSEDESPNGNKVHAEVIFNISIELK--NDEKPIR-MVDKLFHVVRNGQRLVTLEDLCYHDSDTD 1054

  Fly  1066 TNHTDIHYIHVSSTNGAFYKSGH---YIDSFTQDDIANRRIMFQHTGADSGTASFIVTDREHEVN 1127
            .....:.|......||....:..   .:..|||:|:..:|::|.|.|:|.|.....|||.:|..:
 Frog  1055 FTDGQLLYTRRGIPNGDLVSANDPSTKLYQFTQEDLEKKRVLFMHQGSDYGRFVLFVTDGKHYTS 1119

  Fly  1128 GLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMK-LDEIYYEVIKPPSYGILMYL 1191
            .|||:.||:|:|.::.....:||:||..::...:..:.|||.:: ..||.|.:...|.||.::..
 Frog  1120 SLLEVSASEPYVKVVNNTGLLVQKGKEQIITISNISIATNLYIESYKEIVYNIASSPKYGKILVQ 1184

  Fly  1192 SRANEGENGTTIYKATNYTSLSNFTHLDIERERLVYWNTEIAS-MDKVRYRVHIKNITAEGEVMF 1255
            ..|.|                 :||||||:...:.:.:.:..: :|.....|.:|||....|:..
 Frog  1185 GSAAE-----------------SFTHLDIKSGHVTFRHDDSNNLLDAFNLTVTLKNIAVNIEIKV 1232

  Fly  1256 RIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLVTSSPMHGYL----EM 1316
            |:|..::.....|...:.|.||:...|.|....|:|||.:..|.:|.:.|.|.|.|||:    .:
 Frog  1233 RVYLESHQRLPTVLNLNILVVEQGRPVKIDERKLQVVHEDNLPKEIIYSVISPPSHGYIRKFESV 1297

  Fly  1317 QSMSFDDEYNCKVFDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGITWLRQLMIKIVIIPEKLYM 1381
            :.....::.:...|.|..:|...:.|:|:...|..|.|..|:||||..:..:.:.:.|||..:.:
 Frog  1298 EGHLTAEKNSILTFTQQDINDGLIHYVQSDPGQLQDNFTVDITNGIRIISGITVSVDIIPLLIPL 1362

  Fly  1382 HSNIISVVEGKTVQLNPTDIQPYSEYYRGKILEYIVTITPSSGHVLAGNS-----KVKRFTQKQL 1441
            .:..|:|.||.:..|....:...::::.|...|:.|...|.:|::  .|:     |:.|||:||:
 Frog  1363 ATQNITVKEGASKALTDEQLNISNKHFAGLNFEFEVIDLPKNGYI--ENTRFPGIKLNRFTRKQV 1425

  Fly  1442 EQGSIQYVHNGSENATDSITLVA--MARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRY 1504
            ||..|.|||:.||...|:.|::.  ...:|.|:|..:...|..:|||.|.:..|:..:||.|...
 Frog  1426 EQELIYYVHDDSETLNDNFTILVNDTDLSKHSLPSTIFVTVSPINDEFPFITANSIFRVWVGSVT 1490

  Fly  1505 VIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIEHFTQAQINLEEIYFMHDSNSRRN 1569
            .:...||.|:|.||.|.:|.|.:.....|:||.||.|::.|.:|||..|:.:.:.|:| |.|...
 Frog  1491 EVTCEDLCAKDKDTSPSDLVFSITPPSNGHLALKSYPNKSILNFTQQHIDDKHLVFVH-SGSMSG 1554

  Fly  1570 ELSFVVTDGLFNTTTQMLNIEIKPIEILAEHNENLHVFPLTKKQILRDYLHFKCSDE----EREI 1630
            ..:|.|||||.....|:.:|..:.:.|..|.|:.|.|||.|::.|..|:|....:||    .|.:
 Frog  1555 GFNFQVTDGLNFAPRQIFSITARTLVINLEANKGLDVFPGTRRAITSDHLKAVTNDESNMKNRTV 1619

  Fly  1631 RYNITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIFYEHT---AVIMEFRTNDSFYFDVVA 1692
            .:.:.|||..|.::  |..:..|:|||.|:|..||.|.||||||   |::  :.|.|||.|...:
 Frog  1620 TFTVVVPPKHGLLM--FGLHNATEEVSGFSQLMVDEGVIFYEHTDNEALL--WNTQDSFTFTASS 1680

  Fly  1693 -----ERSDRLLNQKFNI-------EISVSSGGLLRFLPVNKLNVDEGGSVPI---KLDFSKILE 1742
                 |.|..|:...:.|       .:..::|.          :|:|||.|.|   |||.|.:|.
 Frog  1681 PPAFLESSVFLITISYEINDPARKSRLRANTGA----------SVEEGGKVLIDKSKLDGSNLLL 1735

  Fly  1743 YL-KTKAGINNPELFIEAIQKPTHGNIGLGHEFKHMQRYHPSDFFTKK--VYYIHDHSDTLEDTI 1804
            .| :|:..  :.|::.:....|.||.|.:|.......:.:.|.:...|  :.|:||.|::|.|..
 Frog  1736 KLPETQRA--SYEVWYQVTSLPNHGMIIVGDRNITKDKPNFSQYIVNKFGITYMHDGSESLADRF 1798

  Fly  1805 LMSVYLTQGNIFLCNLTIPVSINP---------------INDQPFHLVTHLPQMTVVEGENRTIT 1854
            ..:.:|        ||....::.|               :|||...|.|..|.:.|::|:...|.
 Frog  1799 TFATWL--------NLKSKSAVKPDTDVLEEMFNFTIIGVNDQSPELKTKRPYLKVLQGQMIAIG 1855

  Fly  1855 RNDLLTEDADTPPEEIIYDVMSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGM 1919
            .::|..||.|.|||:|.|.::|.|..|.|      ...|:|.|..:.|||||||:..:.:|..|.
 Frog  1856 SDNLNVEDLDNPPEDIKYTIISTPNNGFL------ANHENLNASVDHFTQADINDGHVWFVQDGS 1914

  Fly  1920 PQSTTFCFTVSDGQSNPAYEIFTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLDHIGVSTNVHME 1984
            ..|..|.|:|:||:..|.|::|.|.:.|:.: ....|..:.:.|..|..|:...|:..:|:...:
 Frog  1915 TSSGVFYFSVTDGKHKPLYKLFNIDVTSVSI-TLVNQTNLVLTQSQTFLPITNMHLAATTDGRSK 1978

  Fly  1985 RLSYNVTNSPLFGIIVYKHQPTLRFTQQQLETSQISYMQTDLNRSNDSFQVSAYV---------- 2039
            .:.|.|...|.:|.::..:.|..:|.|..|...::.|...:|..|.|||::.|..          
 Frog  1979 EILYEVVQMPTYGQVMIDYAPVTKFGQIDLNLGKVKYHVRNLTESQDSFELMAMTSESNLTGLVL 2043

  Fly  2040 -----PGTNYVAQVDVVMEVEPVIQINDIVMKEAESSGGKIKLITSLDNDNPLSLKLNKFNPKFV 2099
                 |..:.::::::..|...:|||.|:...|..:..|.                    :|:|.
 Frog  2044 NVTLKPLVHVISKLEIPTETIYIIQIKDLDASELANVTGS--------------------DPEFH 2088

  Fly  2100 ITRMPSTGQI--RKIIRSTGLTTDGQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQ 2162
            |...|..|::  ||:.:|     |...|.:  :|:..|:.:|.|......::..||..:|||.:.
 Frog  2089 IIDEPGYGRLMRRKMPQS-----DAYEDIA--MFTQAEIETGRVLLEVSANLTYTEMQNDSFSFL 2146

  Fly  2163 LLIKTVQPA----------------QATVSIEYRSRVEETETVHLGS------------------ 2193
            |....|.||                ||..|..|.| ...||:.|..|                  
 Frog  2147 LKASNVPPALGVFSYSVVPNDPLLFQAVTSEGYLS-ASTTESSHTSSVYEKRTPNYWLNNTSTVV 2210

  Fly  2194 ----------------------------------------------AGLSINYLAIGCAIFIVLI 2212
                                                          |..|.|..::...|.:|::
 Frog  2211 PNIKNVPKWGNRNRWGNQNNEELLFSEATTSSFREATVGANPISPKAEASQNGSSLSVIIPLVIL 2275

  Fly  2213 CLLIVLLILKIRKLRKHKADISKDQPPALPCPPDLTSVSPQHHLHHHHGHHYASSEADSVPATGN 2277
            .|||:..||.:..|.|.|                 |..:|||          ..|.:.||.....
 Frog  2276 VLLILAAILIVWFLMKRK-----------------TKKAPQH----------VKSNSYSVVPQVP 2313

  Fly  2278 STPLPGFSNIPHCKIIPVESYKHEY----PDYDPDEEETDDQCDPQQMMLPQRYNPYHMEHDAWS 2338
            |..:...:.||...:.|::. .|||    |...|.:..|.....|......|:.:..||:     
 Frog  2314 SPYMERSATIPTVTVTPLQK-SHEYVSVSPLLPPRQAHTYASSSPSLTENAQQNSWLHMD----- 2372

  Fly  2339 SSCDMANDFAGYASVPQSISGSVSSPPSAPPTNPLLRRNQYWV 2381
                           |:.:.       ....|||.|:.|||||
 Frog  2373 ---------------PEMLQ-------HCRTTNPTLKNNQYWV 2393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058 48/149 (32%)
LamG 211..365 CDD:238058 49/167 (29%)
Cadherin_3 507..664 CDD:292802 43/160 (27%)
Cadherin_3 631..776 CDD:292802 50/148 (34%)
Cadherin_3 747..892 CDD:292802 32/148 (22%)
Cadherin_3 861..1005 CDD:292802 32/145 (22%)
Cadherin_3 979..1121 CDD:292802 45/153 (29%)
Cadherin_3 1093..1242 CDD:292802 43/150 (29%)
Cadherin_3 <1264..1361 CDD:292802 28/100 (28%)
Cadherin_3 1330..1464 CDD:292802 43/138 (31%)
Cadherin_3 1436..1578 CDD:292802 53/143 (37%)
Cadherin_3 1789..1932 CDD:292802 49/159 (31%)
Cadherin_3 2009..2163 CDD:292802 37/170 (22%)
cspg4bXP_002941158.3 Laminin_G_2 53..178 CDD:396680 44/126 (35%)
LamG 215..369 CDD:238058 48/163 (29%)
Cadherin_3 433..524 CDD:406568 28/98 (29%)
Cadherin_3 538..648 CDD:406568 30/116 (26%)
Cadherin_3 652..763 CDD:406568 39/111 (35%)
Cadherin_3 882..991 CDD:406568 26/112 (23%)
Cadherin_3 1009..1114 CDD:406568 33/107 (31%)
Cadherin_3 1133..1220 CDD:406568 22/103 (21%)
Cadherin_3 1243..1342 CDD:406568 28/98 (29%)
Cadherin_3 1349..1450 CDD:406568 30/102 (29%)
Cadherin_3 1456..1563 CDD:406568 38/107 (36%)
Cadherin_3 1569..1679 CDD:406568 42/113 (37%)
Cadherin_3 1689..1800 CDD:406568 30/122 (25%)
Cadherin_3 1822..1927 CDD:406568 38/110 (35%)
Cadherin_3 2041..2145 CDD:406568 27/130 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9007
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H136179
Inparanoid 1 1.050 792 1.000 Inparanoid score I501
OMA 1 1.010 - - QHG46545
OrthoDB 1 1.010 - - D119072at33208
OrthoFinder 1 1.000 - - FOG0003479
OrthoInspector 1 1.000 - - otm49119
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4086
SonicParanoid 1 1.000 - - X2369
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.010

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