DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10283 and Ccdc50

DIOPT Version :9

Sequence 1:	NP_001163006.1	Gene:	CG10283 / 35102	FlyBaseID:	FBgn0032681	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	XP_017453409.1	Gene:	Ccdc50 / 288022	RGDID:	727841	Length:	479	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	132/638 - (20%)
Similarity:	212/638 - (33%)	Gaps:	230/638 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VNEVCKEWLVREDGALAYKLQSQEINDFYKGNRYRNAVVREDFPTA---LHEQIKEKEQAQRRVD 84
            |.|||:::.|.||..||:.||.|||......|..||.:|:.|...|   ..|.:|.:.|.|:|..
  Rat    14 VKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNIQRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYK 78

  Fly    85 AYRRRLTEQEEHDKRVAKEIADKL-----ERDLQEQQQKELMQSELIAKQMQEIYVNLPPVPPPV 144
            |.       |:||..:|:||.:||     .|.:||::.:::.:. |..|::||          ..
  Rat    79 AL-------EQHDCEIAQEIQEKLTIEAERRRIQEKKDEDIARL-LQEKELQE----------EK 125

  Fly   145 TRDKSRPPPRPAKASIHLQQQQQTQQTQSTQQQH-----------QPEPSTSQQARYHSQLQQQQ 198
            .|.|..|......||......:...|::|.:.:.           |.:..|.:|   ...|:.:|
  Rat   126 KRKKHTPEFSGGSASGDNYYYEDGDQSRSRRDRELGSGHSKSGRLQNDGKTVKQ---KENLRHRQ 187

  Fly   199 QQPLQLQQQHFSQTDNYVGLSLIPNIVDLPGAT---------AACTTPSRNAQAHNQLLVSDVLP 254
            :...:|.:||             |:...||..:         .||....|..:...:...|. ||
  Rat   188 ENLEELDEQH-------------PSERPLPSVSWGRGRDDVHTACEQQERKQRGRERPWKSP-LP 238

  Fly   255 ------------------SPQQQQQQHHSRFHHAQQPPQQQQHQSSSPARRARAPTNAITSATTN 301
                              ||.....:..|| ||.:..|:..|                    .|.
  Rat   239 KISGEVFLTGSEDWEANCSPGTPSWEKQSR-HHGRLSPKSSQ--------------------KTG 282

  Fly   302 MPSTSSITQHPPTHTEHPADIDELVDYADVADSIRDYNIAATSATATSASVVDAAATSLQKQRSP 366
            :|                  ..|:|...|:...
  Rat   283 LP------------------CKEIVYGRDLGQG-------------------------------- 297

  Fly   367 SHENLLRTEPKFQKLSPEKYDQLVGNFGLGSVSGLGSGSVSGSGSGSAKAAERHMQQHADDIELY 431
            :|.. .|..|:....|.:|      ......|:|:.|..::.:.|..|:.:.|       |.|.|
  Rat   298 NHRE-RRHRPRTSPFSEDK------ELRHHHVAGMKSRGINEAVSAPARVSHR-------DQEWY 348

  Fly   432 VDPCDYASLREIGLPLEEIQEISKKMKQEQKDELLARRLQAIESKDCVRQEHRDRLLAIEAQDKE 496
                              ..||::|:   |::||||              .|.|...|..|||:|
  Rat   349 ------------------DAEIARKL---QEEELLA--------------THMDIRAAQVAQDEE 378

  Fly   497 LAKML--QDRMNSKKLFSCRYNYLGFRKE----KAKAKRAKEKARLRKTQQKEAAEAANGNGNLL 555
            :|::|  :::...||......:.|..||.    |:|||.|..|::.....|:...:.
  Rat   379 IARLLMAEEKKAYKKAKDREKSSLDKRKHDYDCKSKAKSAHSKSKEGDETQRAKIDR-------- 435

  Fly   556 CGTNSHCGPLLPLPPDCLSSNANQSQADIDVEAYSNP-IDVLNSSREQRPHNG 607
                    |..|.||      |..:..|:|...::|. .:..:.|:.:..|.|
  Rat   436 --------PSRPPPP------AAMAPEDVDPTHFTNQHSNTRHFSKSESSHKG 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10283	NP_001163006.1	RILP-like	14..132	CDD:304877	39/116 (34%)
CG10283	NP_001163006.1	HTH_MerR-SF	<440..497	CDD:295384	14/56 (25%)
Ccdc50	XP_017453409.1	CCDC50_N	7..126	CDD:291941	41/129 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354540
Domainoid	1	1.000	61	1.000	Domainoid score	I10240
eggNOG	1	0.900	-	-		E1_2B49I
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005601
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22115
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800