DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsf and lrpprc

DIOPT Version :9

Sequence 1:	NP_523596.2	Gene:	bsf / 35100	FlyBaseID:	FBgn0284256	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_001136064.1	Gene:	lrpprc / 557195	ZFINID:	ZDB-GENE-030131-7887	Length:	1436	Species:	Danio rerio

Alignment Length:	1558	Identity:	409/1558 - (26%)
Similarity:	702/1558 - (45%)	Gaps:	286/1558 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASILRTGKLLRYFAGFTRNVLVNSVRENETSNLLNNA--------------------------- 38
            ||::||:.:||:..:.....|:.||........|.:.|
Zfish     1 MAALLRSARLLKTSSASLIQVIGNSKHAPAAGRLYSGAIGTLRVGVCGRQTVPGRLNANSLFSYR 65

  Fly    39 ---PCM-CGQF-----QNGFATNAAAKAELS-----LDKQIRRLDQDVRRIGRISRRDLEEVLDE 89
               ||: |.|:     |:|...:.|:.|..|     .|..:.:||..|||.||:::..|..:..:
Zfish    66 PALPCVSCRQYAVVPEQSGQVKDEASLAVRSKQAQQFDWALSKLDSSVRRTGRVTKTLLLHIFHD 130

  Fly    90 IRSHRTATSSQSLLVIRCCGNLVPEELPEVRTALVQEIWKTLNALNVPMDISHYNALLRVYLENE 154
            |......:.:|:||::|.||:|:||.....||.||:.||..|..|.|..|:|||||||:.||:||
Zfish   131 ICRTGYPSGNQALLLLRSCGSLLPEVPLAERTELVKRIWDKLLELGVSYDVSHYNALLKTYLQNE 195

  Fly   155 HGFAPTDFLAEIEAKGIEPNRVTYQRLIARYCQQGDIEGATRILEFMRAKSLPVNENVFNSLILG 219
            ..|:||||||::||..::|||||||||||.||::|:||||:.||.||:.|.||:.|.|||||::|
Zfish   196 FRFSPTDFLAKMEAANVQPNRVTYQRLIAAYCEEGNIEGASAILGFMKNKDLPITEAVFNSLVVG 260

  Fly   220 HSQANDLESAKGILGVMMQAGLEPSADTYTTLLCAFARHGDLAAVKETLAECEQKEIILLDKDLL 284
            |::|.|:.|::|||.||..||:||..|||.:||..:|..||:..:|:||...|..:..|:|:||:
Zfish   261 HARAGDITSSEGILSVMKSAGIEPGPDTYLSLLNMYAEKGDIDKIKQTLDVVENADFFLMDRDLM 325

  Fly   285 DIVYTLTVNGNGEHVDDVLTKLRLSPGFNQDAVNVILRLVNKGHEDVGLKLLRVMPRSSRVN-GE 348
            .:|.:|...|:.:||.::::::|...|:..||:|:.|.|:..|||.....:|:.:......: |:
Zfish   326 QLVSSLARTGHEQHVPEIVSRMRHERGYVPDAINLCLNLITHGHEKTAFSVLKSLTGMLDTHTGD 390

  Fly   349 PVDVGAFFIRQMVKANRPVEKILSICKSLQSEGLNPKALTIATEAGLTNGVINNALPLLQEMKNA 413
            ..|.|.||:|..|..::..|.|:..||.|:..||:...|....:..|.....:.::.|::.||..
Zfish   391 TPDFGNFFLRHCVNMDKSAEDIVGFCKDLKDLGLHSTPLQFTLQCALEGKKTSLSIGLMKRMKAE 455

  Fly   414 GLPIRQHYFWPLICSAESNQ----VLEIVRRMQQEFSVFPNSETVRDYVIPNLKEKNWERIVTSL 474
            .|||:.|||.||......::    ::|::|.| ||.||.|:.:....|::|:.  .:.:....||
Zfish   456 SLPIKPHYFLPLFAHHHKDKNIPAIIEVLRGM-QEMSVSPDVDAFSFYILPSF--PSLDNAKASL 517

  Fly   475 RDAGVPNSTAVTSAVYSALVTHQI------AEAAKIMEKNRAYYVPFL----FKQPLILALSHTN 529
            ::|||..:|       ..|:..::      ...||::....:..:|.:    |:..||.......
Zfish   518 KEAGVDVNT-------DGLIVAELRVQAYSGNLAKLLSLMSSPALPTIDLSVFRAGLIAGFKRFQ 575

  Fly   530 DYASFIRCVRQIHEGLQFR--------------------------QGKDEEVEQVEGVAAVPTER 568
            :..:..:....:::..:|.                          |..:|::.:..|:.......
Zfish   576 NVENMAKITELLYKDARFAADGHDASENVGYFLYNLIDSMSETELQSNEEKIREYFGLLKSMNIN 640

  Fly   569 ITPDVVGAIVQEATTYFRRDRGATLEKILKGLVKQGLSISSDKATQLSEQLGSELTPKISELLGK 633
            |:.::           ||..|.......:..|||:.|:: .||...::|           .::.:
Zfish   641 ISVNI-----------FRGIRNILESHHVPELVKEALTL-VDKTDDMTE-----------VMMFR 682

  Fly   634 LSSGELEPVPLPNSGKRSLDSLSINELERFIVNVEGKGENANNIKRQLLNACFRSQNLEKTLQVI 698
            .|.|.                  |:.|.:.:...:.:|:.|:...::|:|.....:.||:.|.:.
Zfish   683 SSEGR------------------ISALVKTLAEQKAEGKPAHLTLKKLINVLSIEEKLEQALDLK 729

  Fly   699 EKLEAEKFQIPVGIYAQLIDLNTHHKKSSEALEIYGKLKAKDATFQLDNLKAVRLADLLLQEERV 763
            .|.|.:   :....||.||:|...|..:.|||::..::..||:...||..|.:.|..:|.:..::
Zfish   730 SKYEDD---MTPAAYATLINLCCRHDNAEEALKLKIEMARKDSEVALDAQKYIALVRVLSKHGKL 791

  Fly   764 DAAFKILEENK-KEVPVAEAEGSYNYMSTVWRILNSLAEAGQPERLRKLFDVLVGANYIVPTNVL 827
            :.|..||:|.| |.:.:.:     |.:..:...:||:|..|..:.:|:|.:.:.......|:|.|
Zfish   792 EEALDILKEMKEKNIMIRD-----NLIGFLTFTMNSIAMKGDADAIRRLQETIFTLGLAKPSNGL 851

  Fly   828 LGPLIKVHLVKDDIPKAIEAFEEICQKYKSTPWKNELACRLIQKEDAANLQKLTDLSTGIHGEVN 892
            ..||:..:|...|...|.:|..|..::|...|..::|.|.|::|.||..|||:.:..|...||:.
Zfish   852 CSPLVTCYLESGDHAGAFDAVMECHKQYNQLPKIHDLMCSLVEKGDALLLQKVMEFLTLERGEMM 916

  Fly   893 SLYDLVFSFVECGRVRQARKILETPGLRTRPQRINSACDRYKNEGLLQPLEGLIEATKDLGHIDR 957
            .||||.|:|::.||.|:||||:||||||.|..|:....::......::|||.|::.|..|...||
Zfish   917 MLYDLFFAFLQTGRNREARKIIETPGLRARSNRLQWFAEKCIAAQQMEPLENLVDMTVKLFECDR 981

  Fly   958 NKIYYTLLLSYDKADEAEKALGLWTKMQEENVTPNDAFLLKLAEILSKKNIDVPF---------- 1012
            :::|:.|.....:.::..||..:|.||||||:.|.:..|..|||||...|.:|||
Zfish   982 DEMYHYLFRLCKETNDWRKAEAIWMKMQEENLAPRERTLRLLAEILKSNNQEVPFEVPKVWFEDD 1046

  Fly  1013 -----VVPETQNEQAKAKKS------------KAKDATTTEAATETAKVAEQPKEKAAKKEPA-- 1058
                 ||||.:...|.|||:            |.:.......|.|...:.::...|.....||
Zfish  1047 KGQSEVVPEKEESSAVAKKTDDRSRLNATIRLKLQSLCKKGEAQEAFDILKEVDSKGIVPGPAIY 1111

  Fly  1059 ----KTETAKPPKTASHLSGFRKAIQANDPDAAISHKQS-VLSG-----------EKIGALDTSR 1107
                |...||        .....||...  |.|:.|..| :||.           :|....|:.:
Zfish  1112 DAIIKALLAK--------GNIEDAISVK--DIAVGHIPSFILSDVANNLLIISHVKKCQMKDSVQ 1166

  Fly  1108 LIELLVRADRLTE---ATKYVEELLGD-------KLHPQPKIF-------KFYLNKIAAA----G 1151
            ::..:::||::..   .|:.|:.|..:       ::....|.|       ..::|..|.|    |
Zfish  1167 VLRDMLKADQMPSQLAITRLVQGLADEGNLKDIQEVEAMTKAFGSFNLSNMLFVNNTALALLNNG 1231

  Fly  1152 DLETMQRIGQQL---NDEQKRLISFDNRFCHANIVAGKAEEFLKHLTTEIDAAKTPEESTKLAEK 1213
            |:::...:.|..   |.|::     :|...|.         |.|.|....|||.  ::.:.:||:
Zfish  1232 DVDSAVDMLQTFYTENTERQ-----NNSIAHV---------FRKVLNANNDAAM--DKLSAMAER 1280

  Fly  1214 FPRGGAVGILEKHPELVPQYQSLAEKFAAHNQLGPMNVLWMHLISTGQEAASKEIWDK--HLSNA 1276
                                  |..:||::.   ....|::..:.||:...:|.:..:  .:...
Zfish  1281 ----------------------LCNQFASYR---AATDLFLVYVDTGRTEEAKFLLQRCAAVGEQ 1320

  Fly  1277 PRLMFQRVLQTAREQQDEKLASTVISQLKNSKISEGAIGNAYSCLI-------DIQTTKGNSDKA 1334
            ..|:|..||:.:::........:::..:.:.:..|    :.||.|:       |:.:.|...::.
Zfish  1321 KDLLFSYVLRASQQPGQAAKVMSLMELIPDIREKE----DIYSQLMKCHGLDQDLASAKALYERM 1381

  Fly  1335 MVVLANAIKDVSLENINRTALLRLKQAVEEKSQKFPYTIPEK--RTKADDSSSSSSSSSSDDD 1395
            .|   ..::      |:...|.||.:...:..:..|:..|.:  |..||......:.|::..|
Zfish  1382 QV---EGVR------IDELTLKRLAKLYRDSGEPVPFEEPAESFRFYADKLKDQRTQSTASID 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsf	NP_523596.2	PPR_2	139..187	CDD:289786	33/47 (70%)
		PPR repeat	142..169	CDD:276811	18/26 (69%)
		PPR_1	169..202	CDD:289614	21/32 (66%)
		PPR_2	173..222	CDD:289786	33/48 (69%)
		PPR repeat	177..204	CDD:276811	18/26 (69%)
		PPR repeat	210..239	CDD:276811	16/28 (57%)
		PPR_2	213..257	CDD:289786	23/43 (53%)
		PPR repeat	245..274	CDD:276811	12/28 (43%)
		Pterin_binding	<456..>543	CDD:294150	15/96 (16%)
		PPR repeat	681..704	CDD:276811	7/22 (32%)
		PPR repeat	710..739	CDD:276811	9/28 (32%)
		PPR repeat	780..818	CDD:276811	7/37 (19%)
		PPR repeat	825..854	CDD:276811	9/28 (32%)
lrpprc	NP_001136064.1	PPR repeat	183..210	CDD:276811	18/26 (69%)
		PPR	211..243	CDD:295754	21/31 (68%)
		PPR_2	214..263	CDD:289786	33/48 (69%)
		PPR repeat	218..245	CDD:276811	18/26 (69%)
		PPR repeat	251..280	CDD:276811	16/28 (57%)
		PPR repeat	286..310	CDD:276811	10/23 (43%)
		PPR repeat	708..735	CDD:276811	7/26 (27%)
		PPR repeat	738..769	CDD:276811	10/30 (33%)
		PPR repeat	775..804	CDD:276811	8/28 (29%)
		PPR	778..806	CDD:279828	8/27 (30%)
		PPR repeat	812..842	CDD:276811	6/29 (21%)
		PPR repeat	1080..1102	CDD:276811	2/21 (10%)
		PPR repeat	1108..1135	CDD:276811	8/36 (22%)
		PPR repeat	1145..1173	CDD:276811	2/27 (7%)
		PPR repeat	1180..1209	CDD:276811	4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32695
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1367
OMA	1	1.010	-	-		QHG46855
OrthoDB	1	1.010	-	-		D64969at33208
OrthoFinder	1	1.000	-	-		FOG0005169
OrthoInspector	1	1.000	-	-		oto41704
orthoMCL	1	0.900	-	-		OOG6_106898
Panther	1	1.100	-	-	LDO	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X345
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880