DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsf and Lrpprc2

DIOPT Version :9

Sequence 1:	NP_523596.2	Gene:	bsf / 35100	FlyBaseID:	FBgn0284256	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_569913.1	Gene:	Lrpprc2 / 31095	FlyBaseID:	FBgn0027794	Length:	1072	Species:	Drosophila melanogaster

Alignment Length:	981	Identity:	257/981 - (26%)
Similarity:	449/981 - (45%)	Gaps:	118/981 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 GNLVPEELP----EVRTALVQEIWKTLNALNVPMDISHYNALLRVYLENEHGFAPTDF---LAEI 166
            |:.|||.||    :.|..|.:.:|..|..|..| .::||:..|:|..:|.  ...||:   ||||
  Fly   128 GSCVPELLPAQSSQERLQLFKGLWAQLIKLGQP-TLAHYHTKLQVLRQNR--LPLTDYRSLLAEI 189

  Fly   167 EAKGIEPNRVTYQRLIARYCQQGDIEGATRILEFMRAKSLPVNENVFNSLILGHSQANDLESAKG 231
            .......:...|..|:......|::..||.||..||.:||.:.|:.|::|:|||:::.||..|:.
  Fly   190 AVYHGAADSTLYGALLDVAGAAGNMRMATEILSEMRERSLALTEHNFHALLLGHARSGDLPGAES 254

  Fly   232 ILGVMMQAGLEPSADTYTTLLCAFARHGDLAAVKETLAE---------CEQKEIILLDKDL-LDI 286
            :|..|..||::..:.|......|...:|.||..||.|..         .:....:|..||: .|:
  Fly   255 VLASMRAAGIQQGSSTQAIWFEALLENGQLAQAKELLQVEHGFTAPQLLQMLRGLLASKDVDTDL 319

  Fly   287 VYTLTVNGNGEHVDDVLTKLRLSPGFNQDAVNVILRLVNKGHEDVGLKLLRVMPRSS-RVNGEPV 350
            :..|.    .|...:.||.:.|.|...    ::.::||::|..:|.::|:..:|... .:..:.|
  Fly   320 IQLLV----KELPREFLTGIDLPPAIR----SLCIQLVHQGRTEVVIQLVGALPAPKFELQNQNV 376

  Fly   351 D-VGAFFIRQMVKANRPVEKILSICKSLQSEGLNPKALTIATEAGLTNGVINNALPLLQEMKNAG 414
            | .||..:::..:|..|:::.:.....|.....|.:||.:..|..|.... ::||..|:::..||
  Fly   377 DEYGALLLQEFFRAQVPLDQTIQFAGQLVQRNQNVRALHLVAELALRRQP-SSALRCLEDLSAAG 440

  Fly   415 LPIRQHYFWPLIC-----SAESNQVLEIVRRMQQEFSVFPNSETVRDYVIPNLKEKNWERI--VT 472
            ..:|.|||||||.     ..||. :|.:|..|:: ..|..:.||:|.|:.|:|::...:.:  |.
  Fly   441 EELRPHYFWPLILHHYRREGESG-MLRLVSEMRR-LRVECDEETLRHYLFPHLRQTLVQPLEAVK 503

  Fly   473 SLRDAGVPNSTAVTSAVYSALVTHQIAEAAKIMEKNRAYYVPFLFKQPL-ILALS--HTNDYASF 534
            :|..|||..|..:...|...|..||::|...::::...........||| .||::  .|..:..|
  Fly   504 ALESAGVKPSQTLCPVVSHLLQQHQMSEVLDLLDRYPTRLDLATLLQPLSSLAVNARATKRFEVF 568

  Fly   535 IRCVRQIHEGLQFRQGKDEEVEQVEGVAAVPTERITPDVVGAIVQEAT---TYFRRDRGATLEKI 596
            .:.:    :.||.:..|..|                 |.||:::.:.|   |..|:| ..:|.:.
  Fly   569 AKVI----QALQQKALKRGE-----------------DFVGSLLLQMTGPQTRLRQD-ATSLRRF 611

  Fly   597 LKGLVKQGLSISSDKATQLSEQLGS---------ELTPKISELLGKLSSGEL----EPVPLPNSG 648
            |..|.:..|.||    ...||.|.|         :|...:::.|.|:.:.:|    :.|.|....
  Fly   612 LHELRRLELQIS----PAASEALLSVVRHATDDVDLIQDLAKTLQKMKNPQLALPADTVSLHGGF 672

  Fly   649 KRSLDSLSINELERFIVNVEGKGENANNIKRQLLNACFRSQNLEKTLQVIEKLEAEKFQIPVGIY 713
            .:....:||:|||..:|.:|.|..|...:.|:||....||..||:..|::.|.:..|.|...|:.
  Fly   673 IKHPRDMSIDELECHLVELESKQLNPRGVLRRLLQLSVRSGRLERAQQLLAKCQVLKVQESAGMM 737

  Fly   714 AQLIDLNTHHKKSSEALEIYGKLKAKDATFQLDNLKAVRLADLLLQEERVDAAFKILEENKKEVP 778
            |.:.||:...:....|.|...:|.:....||:|..|.:..|.||:|.::::||.::|:...::..
  Fly   738 ASIFDLHIKLRDLPRAQESLERLSSMYPAFQIDEHKVIDYAALLVQGQQLEAAKQLLQRRAEQHK 802

  Fly   779 VAEAEGSYNYMSTVWRILNSLAE------AG-----QPERLRKLFDVLVGANYIVPTNVLLGPLI 832
            |  ..|.| .|..||::|.::.:      ||     |..:.|:..|.|.|..|....|.||||::
  Fly   803 V--VGGDY-VMKNVWQLLTNVGQLAASSHAGGESSKQLNQTREWLDFLRGLGYCQSQNALLGPVV 864

  Fly   833 KVHLVKDDIPKAIEAFEEICQKYKSTPWKNELACRLIQ----------------KEDA-ANLQKL 880
            :..|:|.::..|:..|:.:...:|.||.:.||...|::                .|.| .:|..:
  Fly   865 REWLLKGNLDAAVAEFQRLANTHKHTPLQFELLSLLVRLGNGDEQELTRFPGVTAESAQQHLAVV 929

  Fly   881 TDLSTGIHGEVNSLYDLVFSFVECGRVRQARKILETPGLRTRPQRINSACDRYKNEGLLQPLEGL 945
            |...:.|||..|....|:.:..|.|:..|.|:::..|..|...:.:...|:....||.::.|..|
  Fly   930 TATVSRIHGAANMNSALLLALAESGKETQLRRLIINPEFRINHELLVKNCEHLGQEGAVRTLLRL 994

  Fly   946 IEATKDLGH-IDRNKIYYTLLLSYDKADEAEKALGLWTKMQ-EENVTPNDAFLLKLAEILSKKNI 1008
            ....:.:.. ||..|||..||..:.::::.|.||.|:.::: ::.:..:..||..|.::|....:
  Fly   995 ARGVRGVQRTIDEQKIYDLLLAQFCRSNDYEAALDLFERLEADDELKVSHEFLRNLVQLLQVNQV 1059

  Fly  1009 DVPFVV 1014
            ::|..:
  Fly  1060 EIPSTI 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsf	NP_523596.2	PPR_2	139..187	CDD:289786	13/50 (26%)
		PPR repeat	142..169	CDD:276811	11/29 (38%)
		PPR_1	169..202	CDD:289614	7/32 (22%)
		PPR_2	173..222	CDD:289786	17/48 (35%)
		PPR repeat	177..204	CDD:276811	9/26 (35%)
		PPR repeat	210..239	CDD:276811	11/28 (39%)
		PPR_2	213..257	CDD:289786	14/43 (33%)
		PPR repeat	245..274	CDD:276811	8/37 (22%)
		Pterin_binding	<456..>543	CDD:294150	21/91 (23%)
		PPR repeat	681..704	CDD:276811	8/22 (36%)
		PPR repeat	710..739	CDD:276811	7/28 (25%)
		PPR repeat	780..818	CDD:276811	12/48 (25%)
		PPR repeat	825..854	CDD:276811	9/28 (32%)
Lrpprc2	NP_569913.1	PLN03218	<197..>292	CDD:215636	31/94 (33%)
		PPR repeat	201..227	CDD:276811	9/25 (36%)
		PPR repeat	233..262	CDD:276811	11/28 (39%)
		PPR repeat	268..292	CDD:276811	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457817
Domainoid	1	1.000	76	1.000	Domainoid score	I8940
eggNOG	1	0.900	-	-		E1_KOG4318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2075
Isobase	1	0.950	-	0.759104	Normalized mean entropy	S7417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D5844at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3507
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.850