DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsf and C04E6.11

DIOPT Version :9

Sequence 1:	NP_523596.2	Gene:	bsf / 35100	FlyBaseID:	FBgn0284256	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_504540.2	Gene:	C04E6.11 / 178978	WormBaseID:	WBGene00015425	Length:	995	Species:	Caenorhabditis elegans

Alignment Length:	1194	Identity:	220/1194 - (18%)
Similarity:	408/1194 - (34%)	Gaps:	357/1194 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GQFQNGFATNAAAKAELSLDKQIRRLDQDVRRIGRISR--------RDLEEVLDEIRSHRTATSS 99
            |.|:...|:....:|. :.|..:.|:.:::|:..|||.        |.:|........|...:..
Worm    49 GDFRGVVASKEKNRAS-NPDVVLSRIQENLRKNYRISGDVILFDVVRQMESGNQNFIDHVVRSPE 112

  Fly   100 QSL-LVIRCCGNLVPEELPEVRTA----LVQEIWKTLNALNVPMDISHYNALLRVYLENEHGFAP 159
            :.: ::|..||:    .|..:.||    :::.:|..|.:....:.:..:||..:|..|||..:.|
Worm   113 RWIPMLIHGCGH----SLSNIETASKNEILERLWAQLQSKLAKVPVYAWNARFQVLNENEVDWDP 173

  Fly   160 TDFLAEIEAKGIEPNRVTYQRLIARYCQQGDIEGATRILEFMRAKSLPVNENVFNSLILGHSQAN 224
            ...|..:|..|:||...|:..::.|....||::|...::..|..|...|:.::..:.:...|...
Worm   174 LKELDNMERSGVEPTIETFHAVVKRISASGDVDGCKNMVYNMARKGFSVDAHINAASVFAFSIRG 238

  Fly   225 DLESAKGILGVMMQAGLEPSADTYTTLLCAFARHGDLAAVKETLAECEQKEIILLDKDLLDIVYT 289
            ....|..:.....:.|.|.|.          ..||  |||:  .|.|..      |.|.|..|..
Worm   239 HYLKADSLCEASTKYGEEGSQ----------LAHG--AAVR--AAACRG------DNDRLRQVLR 283

  Fly   290 LTVNGNGEHVDDVLTKLRLSPGFNQDAVNVILRLVNKGHEDVGLKLLRVMPRSSRVNGEPVDVGA 354
            .:|.|:.:       ||.||   :.|.:..|.::..|..:..|
Worm   284 KSVIGSTK-------KLFLS---STDILETIWQMAEKSRDGKG---------------------- 316

  Fly   355 FFIRQMVKANRPVEKILSICKSLQSEGLNPKALTIATEAGLTNGVINNALPLLQEMKNAGLPIRQ 419
                  .:.::.||::|: | :|:..|...|                    |.:|       |.:
Worm   317 ------AECSQLVEQMLN-C-TLRDSGFFRK--------------------LFRE-------IER 346

  Fly   420 HYFWPLICSAESNQVLEIVRRMQQEFSVFPNSETVRDYVIPNLKEKNWERIVTSLRDAGVPNSTA 484
            |     |||          |......|:..:::.|.|.:....|.....::|..|.
Worm   347 H-----ICS----------RHYYTALSLLEDTKRVSDCLENQRKNAFLHQLVGRLS--------- 387

  Fly   485 VTSAVYSALVTHQIAEAAKIMEKNRAYYVPFLFKQPLILALSHTNDYASF-IRCVRQIHEGLQFR 548
             |..:.|....|.|.:.|     ||.::             :..|.|:.. ||    :::.|.|.
Worm   388 -TQLIRSHEPAHLIRDIA-----NRVHF-------------TFNNKYSKLKIR----MYDDLLFA 429

  Fly   549 --QGKDEEVEQVEGVAAVPTERITPDVVGAIVQEATTYFRRDRGATLEKILKGLVKQGLSISSDK 611
              ..||.:::          :|:.  ...:.|.|..|  ||:|               :.|:...
Worm   430 TLMLKDMDLD----------DRLR--YFRSFVDEIDT--RRER---------------IHITLPL 465

  Fly   612 ATQLSEQLGSELTPKISELLGKL--------SSGELEPV------PLPNSGKRSLDSLSINELER 662
            .|  |||   .|..::: :|.:|        ||.|.||:      ||.|||:.
Worm   466 MT--SEQ---NLDQRLA-ILYRLSTMGYRDWSSIENEPLVQIILQPLYNSGRP------------ 512

  Fly   663 FIVNVEGKGENANNIKRQLLNACFRSQN-LEKTLQVIEKLEAEKFQIPVGIYAQLIDLNTHHKKS 726
                                   ||:|: |:|..::::.         .||..:.:.:..|.
Worm   513 -----------------------FRNQSKLDKLARILKS---------YGISERQVWMILHR--- 542

  Fly   727 SEALEIYGKLKAKDATFQLDN------LKAVRLADLLLQEERVDAAFKILEENKKEVPVAEAEGS 785
                  :.|.|||....|.:.      .|.:|........|..::. |....|...:|
Worm   543 ------WSKQKAKQEAPQPEEQWSRPYAKDLRGWCRAYYSETFESP-KTTMNNSIPIP------- 593

  Fly   786 YNYMSTVWRILNSLAEAGQPERLRKLFDVLVGANYIVPTNV--LLGPLIKVHLVKDDIPKAIEAF 848
                   :..|.|..:.|.   :.|:..||....:.|.|:.  ::.|::.::|:.:.........
Worm   594 -------YEKLKSCVDQGD---ITKVSSVLCSNGWPVDTDFGEIVPPVLNLYLMHESWKNVRSML 648

  Fly   849 EEIC-------QKYKSTPWKN----ELACRLIQKEDAANLQKLTDLSTGIHGEVNSLYDLVFSFV 902
            |||.       :....:|.||    .:..|:.::||..:::.:||.:.    |:.:|:.....:.
Worm   649 EEIAAFSGEWNEDPSKSPMKNFHLLSVLRRMAEEEDTLSIRAITDYAY----ELRTLFPHATCYY 709

  Fly   903 ECGRVRQARKILETPGLRTRPQRINSAC-DRYKNEGL-LQPLEGLIEATKDLGHIDRNKI----- 960
            |        ...||   :|..:::...| :|.:.:|| ...::.||:..:.|..:|..::
Worm   710 E--------GFFET---QTEYKKLFVKCFERLERQGLTTSTVDELIDFLRCLVKLDLIQLHPSES 763

  Fly   961 ----YYTLLLSYDKADEAEKALGLWTKMQEENVTPNDAFLLK---LAEILSKKNIDVPFVVPETQ 1018
                :..:||.  :...|| ||..|.|.......||....|.   |.:...:..:::.||:....
Worm   764 LTVFFINILLK--RLGWAE-ALSTWQKFLSSLHCPNGTVALLRHCLQQNTDEARMNLQFVLHRGS 825

  Fly  1019 NEQAKAKKSKAKDATTTEAATETAKVAEQPKEKAAKKEPAKTETAKPPKTASHLSGFRKAIQAND 1083
            ...::::.|          |...|.:....|.:.|:|...:......|...........:::|..
Worm   826 TFLSQSRMS----------AMHFAVLISMRKFEDAEKFCDQLSHKVDPNDCLMAMRLMNSLKARS 880

  Fly  1084 PDAAISHKQSVLSGEKIGALDTSRLIELLVRADRLTEATKYVEELLGDKLHPQPKIFKFYLNKIA 1148
            .|.......:.|...|:|..|...:.:.: :||.|.         :.|..|..|...:.|
Worm   881 VDDQFMLDFAALCLRKLGLSDNKEVAQSM-QADLLR---------ICDTRHMGPTALRVY----- 930

  Fly  1149 AAGDLETMQRIGQQLNDEQKRLIS 1172
                 :.....|.:|.:|:|..::
Worm   931 -----DLFSEYGVELREEEKNRLA 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsf	NP_523596.2	PPR_2	139..187	CDD:289786	14/47 (30%)
		PPR repeat	142..169	CDD:276811	9/26 (35%)
		PPR_1	169..202	CDD:289614	8/32 (25%)
		PPR_2	173..222	CDD:289786	9/48 (19%)
		PPR repeat	177..204	CDD:276811	6/26 (23%)
		PPR repeat	210..239	CDD:276811	2/28 (7%)
		PPR_2	213..257	CDD:289786	5/43 (12%)
		PPR repeat	245..274	CDD:276811	7/28 (25%)
		Pterin_binding	<456..>543	CDD:294150	15/87 (17%)
		PPR repeat	681..704	CDD:276811	5/23 (22%)
		PPR repeat	710..739	CDD:276811	5/28 (18%)
		PPR repeat	780..818	CDD:276811	6/37 (16%)
		PPR repeat	825..854	CDD:276811	5/37 (14%)
C04E6.11	NP_504540.2	PPR repeat	189..218	CDD:276811	6/28 (21%)
C04E6.11	NP_504540.2	PPR repeat	224..248	CDD:276811	2/23 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106898
Panther	1	1.100	-	-	LDO	PTHR46669
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3680
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.890