DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsf and LRPPRC

DIOPT Version :9

Sequence 1:	NP_523596.2	Gene:	bsf / 35100	FlyBaseID:	FBgn0284256	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_573566.2	Gene:	LRPPRC / 10128	HGNCID:	15714	Length:	1394	Species:	Homo sapiens

Alignment Length:	1406	Identity:	425/1406 - (30%)
Similarity:	694/1406 - (49%)	Gaps:	154/1406 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ATNAAAKAELSLDKQIRRLDQDVRRIGRISRRDLEEVLDEIRSHRTATSSQSLLVIRCCGNLVPE 114
            :|.::.|.....|..:.|||..|||.|||.::.|::|.::.........|.:||::|.||:|:||
Human    72 STFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPE 136

  Fly   115 ELPEVRTALVQEIWKTLNALNVPMDISHYNALLRVYLENEHGFAPTDFLAEIEAKGIEPNRVTYQ 179
            ...|.||.....||.||..|....|:|||||||:|||:||:.|:||||||::|...|:|||||||
Human   137 LKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQ 201

  Fly   180 RLIARYCQQGDIEGATRILEFMRAKSLPVNENVFNSLILGHSQANDLESAKGILGVMMQAGLEPS 244
            ||||.||..||||||::||.||:.|.|||.|.||::|:.||::|.|:|:|:.||.||..||:||.
Human   202 RLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPG 266

  Fly   245 ADTYTTLLCAFARHGDLAAVKETLAECEQKEIILLDKDLLDIVYTLTVNGNGEHVDDVLTKLRLS 309
            .|||..||.|:|..||:..||:||.:.|:.|:.|:|:|||.|:::.:..|..::|.::|.|:...
Human   267 PDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCE 331

  Fly   310 PGFNQDAVNVILRLVNKGHEDVGLKLLRVMPRSSRVNGEPVDVGAFFIRQMVKANRPVEKILSIC 374
            ..:..||:|:||.||.:..|||.|::|...| .|:.:| |...|:||::..|..|.||||:...|
Human   332 RRYIPDAMNLILLLVTEKLEDVALQILLACP-VSKEDG-PSVFGSFFLQHCVTMNTPVEKLTDYC 394

  Fly   375 KSLQSEGLNPKALTIATEAGLTNGVINNALPLLQEMKNAGLPIRQHYFWPLICSAESNQ----VL 435
            |.|:...::...|.......|.....:.|..|::.:|..|.|||.||||||:......:    ::
Human   395 KKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGII 459

  Fly   436 EIVRRMQQEFSVFPNSETVRDYVIPNLKEKNWERIVTSLRDAGVPNSTAVTSAVYSALVTHQIAE 500
            ||::.| ||..|.|:.||..|||||.....|..|.:  |::.|..:.:.:.|         |...
Human   460 EILKGM-QELGVHPDQETYTDYVIPCFDSVNSARAI--LQENGCLSDSDMFS---------QAGL 512

  Fly   501 AAKIMEKNRAYYVPFLFKQPLILALSHTNDYASFIRCVRQIHEGLQFRQGKD----EEVEQVEGV 561
            .::....|..:.:.||....|.::|....  :|.:         |.||:..:    .|:
Human   513 RSEAANGNLDFVLSFLKSNTLPISLQSIR--SSLL---------LGFRRSMNINLWSEI------ 560

  Fly   562 AAVPTERITPDVVGAIVQ------EATTYFRRDRGATLEKILKGLVKQGLSISSDKATQLSEQLG 620
                ||.:..|  |...|      ||..||       |..::..:....:....:...|...||
Human   561 ----TELLYKD--GRYCQEPRGPTEAVGYF-------LYNLIDSMSDSEVQAKEEHLRQYFHQL- 611

  Fly   621 SELTPKISELLGKLSSGELEPVPLPNSGK--------RSLD-----SLSINELERFIVNVEGKGE 672
            .::..||.|.:.:.....||...:|...|        ::||     .|:.:|||..:..::.:.:
Human   612 EKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQ 676

  Fly   673 NANNIKRQLLNACFRSQNLEKTLQVIEKLEAEKFQIPVGIYAQLIDLNTHHKKSSEALEIYGKLK 737
            ...::.:||:......:|::|.|::..|.|::   :..|.||.||:|...|.|..:||.:..:..
Human   677 PIRDVLKQLILVLCSEENMQKALELKAKYESD---MVTGGYAALINLCCRHDKVEDALNLKEEFD 738

  Fly   738 AKDATFQLDNLKAVRLADLLLQEERVDAAFKILEENK-KEVPVAEAEG-SYNYMSTVWRILNSLA 800
            ..|::..||..|.|.|..:|.:..::..|..||:|.| |:|.:.:... |:.:|      ||..|
Human   739 RLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHM------LNGAA 797

  Fly   801 EAGQPERLRKLFDVLVGANYIVPTNVLLGPLIKVHLVKDDIPKAIEAFEEICQKYKSTPWKNELA 865
            ..|:.|.:::|.:.:|......|:..:..||:.|||.|.|:..|:|...:..:|||..|..:::.
Human   798 LRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVL 862

  Fly   866 CRLIQKEDAANLQKLTDLSTGIHGEVNSLYDLVFSFVECGRVRQARKILETPGLRTRPQRINSAC 930
            |:|::|.:...:||..|..:...||:..||||.|:|::.|..::|:||:||||:|.|..|:...|
Human   863 CKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFC 927

  Fly   931 DRYKNEGLLQPLEGLIEATKDLGHIDRNKIYYTLLLSYDKADEAEKALGLWTKMQEENVTPNDAF 995
            ||......::.||.|:|.|:.|...||:::||.||..|....:.::|..:|.|:|||||.|.:..
Human   928 DRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKT 992

  Fly   996 LLKLAEILSKKNIDVPFVVPETQNEQAKAKKSKAKDATTTEAATETAKVAEQPKEKA-------- 1052
            |..|||||.:.|.:|||.|||...|..|...:.:..:||.....:...:|.:..:|.
Human   993 LRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLN 1057

  Fly  1053 AKKEPAKTETAKPPKTASHL-------SGFRKAIQANDPDAAISHKQSVLSGEKIGALDTSRLIE 1110
            ||::    ......:|.|:|       ..|.:|::..      :..::.:.|..:.....||||.
Human  1058 AKEQ----NIVFNAETYSNLIKLLMSEDYFTQAMEVK------AFAETHIKGFTLNDAANSRLII 1112

  Fly  1111 LLVRADRLTEATKYVEELLGDKLHPQPKIFKFYLNKIAAAGDLETMQRIGQQLNDEQKRL----I 1171
            ..||.|.|.||...::.:|..:..|........:..:|..||:|.::.:.:.||..:..:    :
Human  1113 TQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKM 1177

  Fly  1172 SFDNRFCHANIVAGK---AEEFLKHLTTEIDAAKTPEESTKLAEKFPRGGAVGILEKHPE-LVPQ 1232
            .|.|....|.|....   |.|.::::.|..:....| :...||..|.:     ::|:..| .|.:
Human  1178 VFINNIALAQIKNNNIDAAIENIENMLTSENKVIEP-QYFGLAYLFRK-----VIEEQLEPAVEK 1236

  Fly  1233 YQSLAEKFAAHNQLG---PMNVLWMHLISTGQEAASKEIWDK--HLSNAPRLMFQRVLQTAREQQ 1292
            ...:||:.|  ||..   |:...::.|:..|:...::.:..:  .::....::...:|:.:|:|.
Human  1237 ISIMAERLA--NQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQG 1299

  Fly  1293 DEKLASTVISQLK-----NSKISEGAIGNAYSCLIDIQTTKGN--SDKAMVVLANAIKDVSLEN- 1349
            .   ||||.|.|:     |.|      ..||:.|:....::.:  |.||:.....| |:..|::
Human  1300 K---ASTVKSVLELIPELNEK------EEAYNSLMKSYVSEKDVTSAKALYEHLTA-KNTKLDDL 1354

  Fly  1350 -INRTALLRLKQAVE-----EKSQKFPYTIPEKRTKADDSS 1384
             :.|.|.| ||.|.|     |..:.|.:...:.|...::||
Human  1355 FLKRYASL-LKYAGEPVPFIEPPESFEFYAQQLRKLRENSS 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsf	NP_523596.2	PPR_2	139..187	CDD:289786	34/47 (72%)
		PPR repeat	142..169	CDD:276811	19/26 (73%)
		PPR_1	169..202	CDD:289614	23/32 (72%)
		PPR_2	173..222	CDD:289786	33/48 (69%)
		PPR repeat	177..204	CDD:276811	19/26 (73%)
		PPR repeat	210..239	CDD:276811	14/28 (50%)
		PPR_2	213..257	CDD:289786	22/43 (51%)
		PPR repeat	245..274	CDD:276811	14/28 (50%)
		Pterin_binding	<456..>543	CDD:294150	17/86 (20%)
		PPR repeat	681..704	CDD:276811	6/22 (27%)
		PPR repeat	710..739	CDD:276811	10/28 (36%)
		PPR repeat	780..818	CDD:276811	9/38 (24%)
		PPR repeat	825..854	CDD:276811	9/28 (32%)
LRPPRC	NP_573566.2	PPR 1	126..160		14/33 (42%)
		PPR repeat	126..156	CDD:276811	13/29 (45%)
		PPR_2	161..209	CDD:289786	34/47 (72%)
		PPR 2	161..195		22/33 (67%)
		PPR repeat	164..191	CDD:276811	19/26 (73%)
		PPR	192..224	CDD:295754	23/31 (74%)
		PPR_2	195..244	CDD:289786	33/48 (69%)
		PPR 3	196..230		24/33 (73%)
		PPR repeat	199..226	CDD:276811	19/26 (73%)
		PPR 4	231..265		16/33 (48%)
		PPR repeat	232..261	CDD:276811	14/28 (50%)
		PPR_2	235..278	CDD:289786	22/42 (52%)
		PPR 5	266..300		15/33 (45%)
		PPR repeat	267..296	CDD:276811	14/28 (50%)
		PPR 6	301..335		9/33 (27%)
		PPR repeat	303..327	CDD:276811	7/23 (30%)
		PPR 7	403..437		6/33 (18%)
		PPR 8	438..472		13/34 (38%)
		PPR 9	678..709		7/33 (21%)
		PPR 10	710..746		11/35 (31%)
		PPR repeat	714..740	CDD:276811	9/25 (36%)
		PPR repeat	746..777	CDD:276811	11/30 (37%)
		PPR 11	747..784		12/36 (33%)
		PPR 12	785..820		9/40 (23%)
		PPR repeat	786..810	CDD:276811	8/29 (28%)
		PPR 13	821..856		12/34 (35%)
		PPR 14	954..988		14/33 (42%)
		PPR 15	1031..1065		5/37 (14%)
		PPR repeat	1039..1061	CDD:276811	4/21 (19%)
		PPR 16	1066..1102		6/41 (15%)
		PPR repeat	1067..1098	CDD:276811	5/36 (14%)
		PPR 17	1103..1137		11/33 (33%)
		PPR repeat	1104..1128	CDD:276811	10/23 (43%)
		RNA-binding	1121..1394		62/291 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32695
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1281
Isobase	1	0.950	-	0.759104	Normalized mean entropy	S7417
OMA	1	1.010	-	-		QHG46855
OrthoDB	1	1.010	-	-		D64969at33208
OrthoFinder	1	1.000	-	-		FOG0005169
OrthoInspector	1	1.000	-	-		oto91475
orthoMCL	1	0.900	-	-		OOG6_106898
Panther	1	1.100	-	-	LDO	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X345
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720