DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP and Ppn

DIOPT Version :9

Sequence 1:	NP_000475.1	Gene:	APP / 351	HGNCID:	620	Length:	770	Species:	Homo sapiens
Sequence 2:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	87/382 - (22%)
Similarity:	128/382 - (33%)	Gaps:	119/382 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    58 GTKTCIDTKEGILQYCQEVYPELQITNVVEANQPV-------TIQNW----------------CK 99
            ||....|:    |:.||......:  |:....|||       ..:.|                ||
  Fly  1706 GTNNRFDS----LEQCQGTCAASE--NLPTCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCK 1764

Human   100 RGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWH-TVAKETC----- 158
            ..:....|  .....|.|      ....::.|:|. |.::..|..|....|| :.:::.|
  Fly  1765 GNKNNYPT--EHACNYNC------RQPGVLKDRCA-LPKQTGDCSEKLAKWHFSESEKRCVPFYY 1820

Human   159 SEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEE----SDNVDSADAEEDDS---DVWWGGADTD 216
            |....|.:::..|..|.....|.|....|.:..|    ::.|.|...:..|.   ..::||
  Fly  1821 SGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGG---- 1881

Human   217 YADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTE 281
             ..|:|::.  ..||..:|..:.:                  .||             ||||...
  Fly  1882 -CGGNENRF--PTEESCLARCDRK------------------PEP-------------TTTTPAT 1912

Human   282 SVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMS 346
            ..:...::||.|:...|.|...:.:|:||...|.|..|:||.||||.|.|:||..|...|
  Fly  1913 RPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRC----- 1972

Human   347 QSLLKTTQEPLA----------RDPVKLPTTA----ASTPDAVDK------YLETPG 383
                 .:|||.|          |.|...||.|    .:.|...||      |.||.|
  Fly  1973 -----LSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKWALHWNYNETEG 2024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP	NP_000475.1	A4_EXTRA	24..188	CDD:128326	30/158 (19%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	28..123		16/87 (18%)
		Heparin-binding. /evidence=ECO:0000269\|PubMed:8158260	96..110		4/29 (14%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	131..189		15/63 (24%)
		Zinc-binding	181..188		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..284		16/92 (17%)
		Kunitz_BPTI	294..341	CDD:333766	19/46 (41%)
		OX-2. /evidence=ECO:0000269\|PubMed:2649245	344..365		6/30 (20%)
		APP_E2	366..548	CDD:372388	9/28 (32%)
		Heparin-binding	391..423
		Heparin-binding	491..522
		Collagen-binding. /evidence=ECO:0000269\|PubMed:8576160	523..540
		Beta-APP	677..713	CDD:367525
		Interaction with PSEN1. /evidence=ECO:0000269\|PubMed:30630874	695..722
		APP_amyloid	716..766	CDD:371108
		Basolateral sorting signal	724..734
		Interaction with G(o)-alpha	732..751
		Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000269\|PubMed:17062754	756..770
		YENPXY motif, contains endocytosis signal. /evidence=ECO:0000269\|PubMed:10383380	757..762
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443	6/18 (33%)
		Kunitz_BPTI	1729..1781	CDD:278443	9/59 (15%)
		Kunitz_BPTI	1789..1840	CDD:278443	11/51 (22%)
		Kunitz_BPTI	1848..1899	CDD:278443	12/57 (21%)
		KU	1920..1973	CDD:238057	23/62 (37%)
		Kunitz_BPTI	2001..2051	CDD:278443	7/24 (29%)
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9914
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810