DRSC/TRiP Functional Genomics Resources

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Protein Alignment APP and CG13748

DIOPT Version :9

Sequence 1:NP_000475.1 Gene:APP / 351 HGNCID:620 Length:770 Species:Homo sapiens
Sequence 2:NP_610430.1 Gene:CG13748 / 35896 FlyBaseID:FBgn0033355 Length:113 Species:Drosophila melanogaster


Alignment Length:53 Identity:24/53 - (45%)
Similarity:32/53 - (60%) Gaps:0/53 - (0%)


- Green bases have known domain annotations that are detailed below.


Human   289 EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
            :.|...|..|.|||:|.||.:|..:.||..|.:|||.||.|||.:.:.||:.|
  Fly    58 QFCLMPARKGVCRALIPRWRYDPEQKKCVEFKFGGCDGNENNFASYKDCMSTC 110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APPNP_000475.1 A4_EXTRA 24..188 CDD:128326
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 28..123
Heparin-binding. /evidence=ECO:0000269|PubMed:8158260 96..110
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 131..189
Zinc-binding 181..188
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..284
Kunitz_BPTI 294..341 CDD:333766 22/46 (48%)
OX-2. /evidence=ECO:0000269|PubMed:2649245 344..365
APP_E2 366..548 CDD:372388
Heparin-binding 391..423
Heparin-binding 491..522
Collagen-binding. /evidence=ECO:0000269|PubMed:8576160 523..540
Beta-APP 677..713 CDD:367525
Interaction with PSEN1. /evidence=ECO:0000269|PubMed:30630874 695..722
APP_amyloid 716..766 CDD:371108
Basolateral sorting signal 724..734
Interaction with G(o)-alpha 732..751
Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000269|PubMed:17062754 756..770
YENPXY motif, contains endocytosis signal. /evidence=ECO:0000269|PubMed:10383380 757..762
CG13748NP_610430.1 Kunitz_BPTI 59..110 CDD:278443 23/50 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2378
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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