Protein Alignment APP and CG16713

DIOPT Version :10

• Sequence 1: NP_000475.1
• Gene: APP / 351
• HGNCID: 620
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_608799.1
• Gene: CG16713 / 33591
• FlyBaseID: FBgn0031560
• Length: 82
• Species: Drosophila melanogaster
• Alignment Length: 42
• Identity: 19/42 - (45%)
• Similarity: 23/42 - (54%)
• Gaps: 0/42 - (0%)

Human   300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
            |.|.|..|.:|....:|..|.|||||||.|.|::.|.|...|
  Fly    39 CEAYIPSWSYDADRNECVKFIYGGCGGNNNRFNSREICEDKC 80

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP	NP_000475.1	A4_EXTRA	24..188	CDD:128326
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	28..123
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	131..189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..284
		Kunitz_ABPP-like	294..341	CDD:438650	18/40 (45%)
		OX-2. /evidence=ECO:0000269|PubMed:2649245	344..365
		APP_E2	366..548	CDD:463752
		Heparin-binding	391..423
		Heparin-binding	491..522
		Collagen-binding. /evidence=ECO:0000269|PubMed:8576160	523..540
		JMTM_Notch_APP	693..767	CDD:425406
		Interaction with PSEN1. /evidence=ECO:0000269|PubMed:30630874	695..722
		Basolateral sorting signal	724..734
		Interaction with G(o)-alpha	732..751
		Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000269|PubMed:17062754	756..770
		YENPXY motif, contains endocytosis signal. /evidence=ECO:0000269|PubMed:10383380	757..762
CG16713	NP_608799.1	Kunitz_SCI-I-like	24..80	CDD:438677	18/40 (45%)