DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncm and AT1G80930

DIOPT Version :9

Sequence 1:	NP_609877.2	Gene:	ncm / 35099	FlyBaseID:	FBgn0086707	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_178208.1	Gene:	AT1G80930 / 844433	AraportID:	AT1G80930	Length:	900	Species:	Arabidopsis thaliana

Alignment Length:	990	Identity:	406/990 - (41%)
Similarity:	572/990 - (57%)	Gaps:	124/990 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSESSSSESSGREEEEAKQEESAKDAKKT-DDTDRGEKRAKERDAGQDEQPTEQKKTPAAEPRSE 91
            |..|||.|.......:.::.|.:.|.::: .:||...:|.:..|   ||           :.:|.
plant     3 RHGSSSDEEERVRRRDRRRRERSPDVRRSRTETDDVARRVRVSD---DE-----------DRKSS 53

  Fly    92 RQHISHSAGVEKQQEEAVAAAEAESEKLNEAKKVETPVQRKEEAEASSVTKELNSPKAQEENAAR 156
            |:.:          |.....|:.|..:.::.::.||....:....:....||.||  ..|::..:
plant    54 RRDL----------EIGGTVADGEGRRGDKVRRKETSDDEELARRSRKDRKEANS--GSEDDRGK 106

  Fly   157 ELEERRKDEEQPVTTNGSSKESPVEAAAETVKPPTADHIEEGEITDKDEDDLPTKEEKKAVASKS 221
            .:|         |.::|..:.                .:.:|..||:...|..:.||.....:|.
plant   107 RIE---------VDSDGDGER----------------RVNKGRNTDRVRADTSSDEEDDLKGNKK 146

  Fly   222 PPKET-----QRKQSRSP-----DGKRRRPRSSS-RSPSPSSRRRRRSRSKGSRTRSRSKSPIRR 275
            .|.|.     :|.:.|||     .|:.|..|.|. .:..||.....|.||:|.|..|:.|....|
plant   147 EPMEVDDDYGRRGRRRSPKVMEKQGRERSHRGSRVIADKPSDEEDDRQRSRGGRRESQRKRRDHR 211

  Fly   276 RSNSLERRRVERQRRHEERDKRDEERAKEREKRHQ---KGEPTSSRRRDDSREKKRSPERKRDRS 337
            .|:..|...:..:||.:|::.|..|...:|::|.:   .|....||||:..|         :|||
plant   212 ASDDDEEGEIRSERRGKEKNDRGSEGLLKRDRRERDLTDGHENGSRRRESER---------KDRS 267

  Fly   338 SSTPKSKSSKTPRHTETTETNADNETVTEPAAKITERQRKTVDV----------------LTSRT 386
            ......:..|..||.:..:.:..::...|.:.|   |:.|.::|                ...:|
plant   268 RRDDGVRDEKERRHNDKYDDSQRDKLRKEDSRK---REEKKIEVPKPKLAELNPSENNAMALGKT 329

  Fly   387 GGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKKSIHGYINKVNVTNIAIITRELLRENIVRGR 451
            ||.||||.||..|..::.||||..|||:.|:||:|||:|.:||||.:||..|..||..||::|||
plant   330 GGVYIPPFKLARMMKEVEDKSSVEYQRLTWDALRKSINGLVNKVNASNIKNIIPELFAENLIRGR 394

  Fly   452 GLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNIGELLLKRLVIQFRRAFRRNDKMVCMSATRF 516
            ||..||.:::|.|||.||.|:||||::||:|||.:.||||||:|:|.:||::||||...::|.:|
plant   395 GLFCRSCMKSQMASPGFTDVFAALVAVINAKFPEVAELLLKRVVLQLKRAYKRNDKPQLLAAVKF 459

  Fly   517 IGHLVNQRVAHEILALEILTLLVETPTDDSVEVAIAFLKECGMKLTEVSSKGIGAIFEMLRNILH 581
            |.|||||:||.||:|||::|:|:..|||||||||:.|:.|||..|.:||.:|:..|||..|.|||
plant   460 IAHLVNQQVAEEIIALELVTILLGDPTDDSVEVAVGFVTECGAMLQDVSPRGLNGIFERFRGILH 524

  Fly   582 EGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVEEDDQFTHLMMLDEATETEDILNVFKFDD 646
            ||::||||||:||.||..||..|:.|.||.|||:||||  :::|.:.||...:.|..|::||.|.
plant   525 EGEIDKRVQYLIESLFATRKAKFQGHPAVRPELDLVEE--KYSHDLSLDHEIDPETALDIFKPDP 587

  Fly   647 NYAENEDKYKGLSREILGSDDGSSSGSGSGSDSDSDSDGESGSDAEKKAEAGDIIDSTETNLIAL 711
            ::.|||.||:.|.:|:|| |:.|....||.:.|:.:.:.|..|| |:..|...|.|.|||||:.|
plant   588 DFVENEKKYEALKKELLG-DEESEDEDGSDASSEDNDEEEDESD-EEDEEQMRIRDETETNLVNL 650

  Fly   712 RRTIYLTINSSLDYEECAHKLMKMQLKPGQEIELCHMFLDCCAEQRTYEKFYGLLAQRFCNINKI 776
            ||||||||.||:|:||..|||:|::|:||||:|||.|.|:||:::|||.::||||.||||.||||
plant   651 RRTIYLTIMSSVDFEEAGHKLLKIKLEPGQEMELCIMLLECCSQERTYLRYYGLLGQRFCMINKI 715

  Fly   777 YIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHLLFTDAISWDVLECIQLNEDDTTSSSRIFIKI 841
            :...||:.|...|...|||:||:||||:|||||||.|||:.|.||..|:|.|:||||||||||||
plant   716 HQENFEKCFVQQYSMIHRLETNKLRNVAKFFAHLLGTDALPWHVLAYIRLTEEDTTSSSRIFIKI 780

  Fly   842 LFQELAEYMGLGKLNAKLKDDVLVESIAGLFPKDNPRNTRFSINFFTSIGLGGLTDDLRRFLKNA 906
            |||||:|::|:..||.:|:|..:.||:..:||||||:||||:|||||||||||:|::||.:|||.
plant   781 LFQELSEHLGIRLLNERLQDPTMQESLESIFPKDNPKNTRFAINFFTSIGLGGITENLREYLKNM 845

  Fly   907 PKSVPAINAEILANAGGNPFRDGSAPAGNTKVAPSSSSSSSSSSDTDSEDSSEEDSSSDSSSESS 971
            |..:                     .....:||.|.|.|||.|..:|||..||..|||     ||
plant   846 PSLI---------------------MQRQKQVAESESGSSSGSDSSDSESESESGSSS-----SS 884

  Fly   972 SSDSSSEPKKKRKRK 986
            |||.|...|:||:|:
plant   885 SSDESDREKRKRRRR 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	MIF4G	421..602	CDD:214713	106/180 (59%)
		MA3	711..817	CDD:280933	68/105 (65%)
		PHA02896	<1107..1300	CDD:165222
AT1G80930	NP_178208.1	PRK12678	33..>283	CDD:237171	69/309 (22%)
		MIF4G	364..546	CDD:214713	107/181 (59%)
		MA3	650..756	CDD:367215	68/105 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	390	1.000	Domainoid score	I148
eggNOG	1	0.900	-	-		E1_KOG2140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	679	1.000	Inparanoid score	I145
OMA	1	1.010	-	-		QHG53878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002777
OrthoInspector	1	1.000	-	-		oto3371
orthoMCL	1	0.900	-	-		OOG6_101743
Panther	1	1.100	-	-	LDO	PTHR18034
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830