DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncm and Cwc22

DIOPT Version :9

Sequence 1:	NP_609877.2	Gene:	ncm / 35099	FlyBaseID:	FBgn0086707	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001349586.1	Gene:	Cwc22 / 80744	MGIID:	2136773	Length:	909	Species:	Mus musculus

Alignment Length:	972	Identity:	472/972 - (48%)
Similarity:	624/972 - (64%)	Gaps:	91/972 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 KQSRSPDGKRRRPRSSSRSPSPSSRRRRRSRSKGSRTRSRSKSPIRRRSNSLERRRVERQRRHEE 293
            |||   .|..||...||         .|||.|...|...:.:||..|..:...|...||.||...
Mouse     9 KQS---SGHNRRETHSS---------YRRSSSPEDRYTEQERSPRDRGYSDYSRSDYERSRRGYS 61

  Fly   294 RDKRDEERAKEREKRHQKGEPTSSRRRDDSREKKRSPERKRDRSSSTPKSKSSKTPRHTETTETN 358
            .|...|.|:::||||.:       |.||       :..|||.|.|.:|....::....:...|
Mouse    62 YDDSMESRSRDREKRRE-------RERD-------ADHRKRSRKSPSPDRSPARGGGQSSPQE-- 110

  Fly   359 ADNETVTEPAAKITERQRKTVDVLTSRTGGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKKSI 423
                   ||..|   :::..:|.|.:||||||||||||||||.|||||||.||||::||||||||
Mouse   111 -------EPTWK---KKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEALKKSI 165

  Fly   424 HGYINKVNVTNIAIITRELLRENIVRGRGLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNIGE 488
            :|.|||||::||:||.:|||:|||||||||||||::|||:|||.|||||||||:|||||||.|||
Mouse   166 NGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGE 230

  Fly   489 LLLKRLVIQFRRAFRRNDKMVCMSATRFIGHLVNQRVAHEILALEILTLLVETPTDDSVEVAIAF 553
            |:||||::.||:.:|||||.:|::|::|:.||:||.||||:|.||:||||:|.||||||||||.|
Mouse   231 LILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGF 295

  Fly   554 LKECGMKLTEVSSKGIGAIFEMLRNILHEGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVE 618
            |||||:|||:||.:||.||||.|||||||.::||||||||||:|.:||||||||..::..|:|||
Mouse   296 LKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVE 360

  Fly   619 EDDQFTHLMMLDEATETEDILNVFKFDDNYAENEDKYKGLSREIL---GSDDGSSSGSGSGSDSD 680
            |||||||::.|::....||:|||||.|.|:.|||:|||.:.:|||   .||..:..|:||..|.:
Mouse   361 EDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEE 425

  Fly   681 SDSDGESGSDAEKKAEAGDIIDSTETNLIALRRTIYLTINSSLDYEECAHKLMKMQLKPGQEIEL 745
            .:.:.|.|.| |:..:...|.|.||.||::.||||||.|.||||:|||||||:||:....|..||
Mouse   426 EEDEEEEGED-EEGGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKEL 489

  Fly   746 CHMFLDCCAEQRTYEKFYGLLAQRFCNINKIYIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHL 810
            |:|.|||||:|||||||:||||.|||.:.|.|:..||.|||:.|.|.|||:||:||||:|.||||
Mouse   490 CNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHL 554

  Fly   811 LFTDAISWDVLECIQLNEDDTTSSSRIFIKILFQELAEYMGLGKLNAKLKDDVLVESIAGLFPKD 875
            |:||::.|.|||||:|:|:.||||||||:||.||||.|||||.||||:|||:.|.....||.|:|
Mouse   555 LYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRD 619

  Fly   876 NPRNTRFSINFFTSIGLGGLTDDLRRFLKNAPKSVPAINAEILANAGGNPFRDGSAPAGNTKVAP 940
            |||||||:||||||||||||||:||..|||.||.:.|          ..|..:...||..:..:.
Mouse   620 NPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVA----------QKPEAEQKKPALTSSSSE 674

  Fly   941 SSSSSSSSSSDTDSEDSSEEDSS--SDSSSESSSSDSSSEPKKKRKRKDKDKKKSKKATKEKSKK 1003
            |||:|.||.|::||.:||.|.||  ||||| |||:.||:........|...||:..||..|:..|
Mouse   675 SSSASDSSDSESDSSESSSESSSDASDSSS-SSSTQSSTSGITAHSAKGTRKKRQGKARGEEVDK 738

  Fly  1004 TKNKKKKKKAEKEQEKEKEKQRKSKKEKEKDKKRKKEEKKAAKKK---SKH-RRKSQESSDS--- 1061
            .....:..:..:|..:|.::.::.:.|:.:.::|:.:..:.|..:   :|| ..:|.|:|.|
Mouse   739 LARGHQALERRREGGREDQRHQEGRTERARSERRRAQNSRDADWRDPLAKHIDDRSHENSHSRVG 803

  Fly  1062 SGSEDSDKSTSESSDSSNSSSDESDAEPQAKIKRQEHVEKN-KFRGRTQDSDEFNLEGPGSKNRF 1125
            :|.|          ..|:...::...||:.:.:|::...:| |.|.|.||||..
Mouse   804 NGRE----------QGSHREPEDRHGEPKKRRERRDSFSENEKQRSRNQDSDNV----------- 847

  Fly  1126 QPNGNGQRRRDNSTGRERNRENSSYDRERNRGNSSYDRERKRGNSSYDRERNRESSYDKERK 1187
                   ||:|.|..|||:|.:|.:..:..|..:|.:|..::.....::.|..:.|.|:.|:
Mouse   848 -------RRKDRSKSRERSRRHSGHKGDDARCQNSAERRWEKPGRRPEQSRESKRSQDRRRE 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	MIF4G	421..602	CDD:214713	131/180 (73%)
		MA3	711..817	CDD:280933	70/105 (67%)
		PHA02896	<1107..1300	CDD:165222	21/81 (26%)
Cwc22	NP_001349586.1	U2AF_lg	9..>168	CDD:273727	78/196 (40%)
		MIF4G	163..344	CDD:214713	131/180 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..443		12/39 (31%)
		MA3	455..561	CDD:367215	70/105 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..909		76/289 (26%)
		PRK12678	717..>902	CDD:237171	47/212 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849311
Domainoid	1	1.000	218	1.000	Domainoid score	I2641
eggNOG	1	0.900	-	-		E1_KOG2140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	839	1.000	Inparanoid score	I444
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002777
OrthoInspector	1	1.000	-	-		otm44082
orthoMCL	1	0.900	-	-		OOG6_101743
Panther	1	1.100	-	-	LDO	PTHR18034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R268
SonicParanoid	1	1.000	-	-		X1867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790