Protein Alignment ncm and CWC22

DIOPT Version :10

• Sequence 1: NP_609877.2
• Gene: ncm / 35099
• FlyBaseID: FBgn0086707
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_065994.1
• Gene: CWC22 / 57703
• HGNCID: 29322
• Length: 908
• Species: Homo sapiens
• Alignment Length: 974
• Identity: 479/974 - (49%)
• Similarity: 646/974 - (66%)
• Gaps: 86/974 - (8%)

  Fly   242 RSSSRSPSPSSRRRRRSRSKGSRTRSRSKSPIRRRSNSLERRRVERQRRHEERDKRDEERAKERE 306
            :||.....|||...||   :...:..|:.||        |.|..|::|...:||..|..|:....
Human     2 KSSVAQIKPSSGHDRR---ENLNSYQRNSSP--------EDRYEEQERSPRDRDYFDYSRSDYEH 55

  Fly   307 KRHQKGEPTSSRRRDDSREKKRSPERKRDRSSSTPKSKSSKTP--RHTETTETNADNETVTEPAA 369
            .|..:...:|...|:..|||:|..||..||.    :|:.|.:|  |:.||:.|.: :....|||
Human    56 SRRGRSYDSSMESRNRDREKRRERERDTDRK----RSRKSPSPGRRNPETSVTQS-SSAQDEPA- 114

  Fly   370 KITERQRKTVDVLTSRTGGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKKSIHGYINKVNVTN 434
              |::::..:|.|.:||||||||||||||||.|||||:|.||||::||||||||:|.|||||::|
Human   115 --TKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISN 177

  Fly   435 IAIITRELLRENIVRGRGLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNIGELLLKRLVIQFR 499
            |:||.:|||:|||||||||||||::|||:|||.|||||||||:|||||||.||||:||||::.||
Human   178 ISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFR 242

  Fly   500 RAFRRNDKMVCMSATRFIGHLVNQRVAHEILALEILTLLVETPTDDSVEVAIAFLKECGMKLTEV 564
            :.:|||||.:|::|::|:.||:||.||||:|.||:||||:|.||||||||||.||||||:|||:|
Human   243 KGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQV 307

  Fly   565 SSKGIGAIFEMLRNILHEGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVEEDDQFTHLMML 629
            |.:||.||||.|||||||.::||||||||||:|.:||||||||..::..|:||||||||||::.|
Human   308 SPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPL 372

  Fly   630 DEATETEDILNVFKFDDNYAENEDKYKGLSREILGSDDGSSSGSGSGSDSDSDSDGESGS---DA 691
            ::....||:|||||.|.|:.|||:|||.:.:|||  |:|         |:||::|.::||   |.
Human   373 EDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEIL--DEG---------DTDSNTDQDAGSSEEDE 426

  Fly   692 EKKAEAGD---------IIDSTETNLIALRRTIYLTINSSLDYEECAHKLMKMQLKPGQEIELCH 747
            |::.|.|:         |.|.||.||::.||||||.|.||||:|||||||:||:....|..|||:
Human   427 EEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCN 491

  Fly   748 MFLDCCAEQRTYEKFYGLLAQRFCNINKIYIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHLLF 812
            |.|||||:|||||||:||||.|||.:.|.|:..||.|||:.|.|.|||:||:||||:|.|||||:
Human   492 MILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLY 556

  Fly   813 TDAISWDVLECIQLNEDDTTSSSRIFIKILFQELAEYMGLGKLNAKLKDDVLVESIAGLFPKDNP 877
            ||::.|.|||||:|:|:.||||||||:||.||||.|||||.||||:|||:.|.....||.|:|||
Human   557 TDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNP 621

  Fly   878 RNTRFSINFFTSIGLGGLTDDLRRFLKNAPKSVPAINAEILANAGGNPFRDGSAPAGNTKVAPSS 942
            |||||:||||||||||||||:||..|||.||.:.|...::..|.        |:|:.::. |.||
Human   622 RNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNK--------SSPSSSSS-ASSS 677

  Fly   943 SSSSSSSSDTDSEDSSEEDSSSDSSSESSSSDSSSEPKKKRKRKDKDKKKSKKATK-EKSKKTKN 1006
            |.|.||.||:||.|||.|.||.:|.|.|.||.||:.....|| |...|.:||:..| .::::|.:
Human   678 SESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRK-KGHGKTRSKEVDKLIRNQQTND 741

  Fly  1007 KKKKKKAEKEQEKEKEKQRKSKKEKEKDKKRKKEEKKAAKKKSKHRRKSQESSDSSGSEDSDKST 1071
            :|:|::.::...:|...:|:.:.||.:|                     |.||.|:..:...|.|
Human   742 RKQKERRQEHGHQETRTERERRSEKHRD---------------------QNSSGSNWRDPITKYT 785

  Fly  1072 SES---SDSSNSSSDESDAEPQAKIK-RQEHVEKNKFRGRTQDSDEFNLEGPGSKNRFQPNGNGQ 1132
            |:.   |:.:|.|...:|.:.:..|. ..:|.:..|.||..::|  |: |.....:|.:.:.| .
Human   786 SDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNS--FS-ENEKHTHRIKDSEN-F 846

  Fly  1133 RRRDNSTGRERNRENSSYDRERNRGNSSYDRERKRGNSSYDRERNRESSYDKERKNRNAVAHDR 1196
            ||:|.|..:|.||::|....:.:|..:.  .||:...||...|::|||..:::|:...:.|..:
Human   847 RRKDRSKSKEMNRKHSGSRSDEDRYQNG--AERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	PTZ00121	<50..>334	CDD:173412	27/91 (30%)
		MIF4G	421..602	CDD:214713	131/180 (73%)
		MA3	711..817	CDD:397128	70/105 (67%)
		PRK12678	1119..>1311	CDD:237171	21/78 (27%)
CWC22	NP_065994.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..129		42/145 (29%)
		MIF4G	164..345	CDD:214713	131/180 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..443		15/49 (31%)
		MA3	455..561	CDD:397128	70/105 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..908		83/290 (29%)
		U2AF_lg	743..>874	CDD:273727	37/155 (24%)
		SF-CC1	821..>902	CDD:273721	26/86 (30%)