Protein Alignment ncm and cwc22

DIOPT Version :9

• Sequence 1: NP_609877.2
• Gene: ncm / 35099
• FlyBaseID: FBgn0086707
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_001071037.2
• Gene: cwc22 / 566033
• ZFINID: ZDB-GENE-060929-452
• Length: 983
• Species: Danio rerio
• Alignment Length: 1176
• Identity: 536/1176 - (45%)
• Similarity: 693/1176 - (58%)
• Gaps: 215/1176 - (18%)

  Fly   104 QQEEAVAAAEAESEKLNEAKKVETPVQRKEEAEASSVTKELNSPKAQEENAARELEERRKDEEQP 168
            :..|:..|........:|....|...||:.:|..||           .|:...|..:||:....|
Zfish     4 ESNESQTAMNMGPTSRDEPPSTEEMEQRQRKASTSS-----------SEDGEHEDNDRRRVVGSP 57

  Fly   169 VTTNGSSK-ESPVEAAAETVKPPTADHIEEGEITDKDEDDLPTKEEKKAVAS-----KSPPKETQ 227
            .:.:||.: .|||..|:     |.|...::...:|.|..|......:|..:|     ::..:||:
Zfish    58 GSRDGSPRVGSPVARAS-----PRAKRDQKSSDSDSDSSDSDDGVMRKIRSSVMHIRRTSDEETK 117

  Fly   228 -RKQSRSPDGKRRRPRSSSRSPSPSSRRRRRSRSKGSRTRSRSKSPIRRRSNSLERRRVERQRRH 291
             |::|.|||  |...:|.|||         ||||: ||:||||:||         |.|..|.||.
Zfish   118 NRERSSSPD--RHEKKSKSRS---------RSRSR-SRSRSRSRSP---------RERYRRARRS 161

  Fly   292 EERDKRDEERAKEREKRHQKGEPTSSRRRDDSREKKRSPERKRDRSSSTPKSKSSKTPRHTETTE 356
            .||: ||....:||.:|.      |||.||       ...|:|.||:|..|:
Zfish   162 RERE-RDRYGDRERYERR------SSRERD-------WEHRRRGRSASPDKN------------- 199

  Fly   357 TNADNETVTEPAAKITERQRKTVDVLTSRTGGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKK 421
               |.....||..|   ::::|:|.:.:||||||||||||||||:|||||||..|||::||||||
Zfish   200 ---DKPPTEEPPVK---KRKETLDPILTRTGGAYIPPAKLRMMQAQITDKSSLEYQRMSWEALKK 258

  Fly   422 SIHGYINKVNVTNIAIITRELLRENIVRGRGLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNI 486
            ||:|.||||||:|||.|.:|||:||||||||||:|||:|||||||.|||||:|:|:|||||||.|
Zfish   259 SINGLINKVNVSNIANIIQELLQENIVRGRGLLARSILQAQAASPIFTHVYSAVVAIINSKFPQI 323

  Fly   487 GELLLKRLVIQFRRAFRRNDKMVCMSATRFIGHLVNQRVAHEILALEILTLLVETPTDDSVEVAI 551
            |||:||||::.||:.:|||||..|::|::|:|||:||.||||:|.||:||||:|.||||||||||
Zfish   324 GELILKRLILNFRKGYRRNDKQQCLTASKFVGHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAI 388

  Fly   552 AFLKECGMKLTEVSSKGIGAIFEMLRNILHEGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPE-LE 615
            :||||||:||||||.:||.||||.|||||||.::||||||||||:|.||||||||| .::|| |:
Zfish   389 SFLKECGLKLTEVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAIRKDGFKDH-PIIPEGLD 452

  Fly   616 LVEEDDQFTHLMMLDEATETEDILNVFKFDDNYAENEDKYKGLSREIL--GSDDGSSSGSGSGSD 678
            ||||:|||||::.|::...|||||||||.|.|:.|||:|||.:.||||  ||.|......|||.|
Zfish   453 LVEEEDQFTHMLPLEDEYNTEDILNVFKLDPNFLENEEKYKTIKREILDEGSSDSGDDAGGSGDD 517

  Fly   679 SDSDSDGESGSDAEKKAEAGDIIDSTETNLIALRRTIYLTINSSLDYEECAHKLMKMQLKPGQEI 743
            .|.|.:.|..:..|:: |...|.|.||.||:|.||||||.|.||||:|||||||:||.....|..
Zfish   518 EDDDEEDEEAAAGEEQ-EKVTIFDQTEVNLVAFRRTIYLAIQSSLDFEECAHKLIKMDFPESQTK 581

  Fly   744 ELCHMFLDCCAEQRTYEKFYGLLAQRFCNINKIYIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFA 808
            |||:|.|||||:|||||||:||||.|||.:.|.|:..||.||::.|:|.|||:||:||||::.||
Zfish   582 ELCNMILDCCAQQRTYEKFFGLLAGRFCLLKKEYMESFEAIFQEQYETIHRLETNKLRNVARIFA 646

  Fly   809 HLLFTDAISWDVLECIQLNEDDTTSSSRIFIKILFQELAEYMGLGKLNAKLKDDVLVESIAGLFP 873
            |||:||::.|.||||::::||.||||||||:|||||||..||||.|||.:|||..|.....||||
Zfish   647 HLLYTDSVPWSVLECVRMSEDTTTSSSRIFVKILFQELCAYMGLPKLNERLKDTTLQPFFEGLFP 711

  Fly   874 KDNPRNTRFSINFFTSIGLGGLTDDLRRFLKNAPKSVPAINAEILANAGGNPFRDGSAPAGNTKV 938
            :||||||||:||||||||||||||:||..||||||.:...|.|:.::       |.|:
Zfish   712 RDNPRNTRFAINFFTSIGLGGLTDELREHLKNAPKMIMTQNQEVESS-------DSSS------- 762

  Fly   939 APSSSSSSSSSSDTDSE-DSSEEDSSSDSSSESSSSDSSSEPKKKRKRKDKDKKKSKKATKEKSK 1002
            :.||||.|||||.:.|| ||||.||.|.|.|:||||..||.....|::|...|||.
Zfish   763 SSSSSSDSSSSSGSSSESDSSESDSDSSSDSDSSSSSGSSSDSDSRRKKASGKKKD--------- 818

  Fly  1003 KTKNKKKKKKAEKEQEKEKEKQRKSKKEKEKDKKRKKEEKKAAKKKSKHRRKSQESSDSSGSEDS 1067
              |:||..|.|.:....|   :|.:|:.:.:.:...||:::.:   .||.|..|.    .|.:|
Zfish   819 --KSKKSSKAANQRSPLE---ERPTKRHENRRQDASKEDRRGS---DKHNRDPQR----RGQQD- 870

  Fly  1068 DKSTSESSDSSNSSSDESDAEPQAKIKRQEHVEKNKFRGRTQDSDEFNLEGPGSKNRFQPNGNGQ 1132
                           :...|.|:.        |..:.||:.                 :|:.:.|
Zfish   871 ---------------ESPPARPRG--------EPERIRGQK-----------------EPHRHAQ 895

  Fly  1133 RRRDNSTGRERNRENSSYDRERNRGNSSYDRERKRGNSSYDRERNRESSYDKERKNRNAVAHDRQ 1197
            ..:|..|...|:::               |.:..|.|...||.|:||    ||         ..:
Zfish   896 DHQDRPTDSGRHKD---------------DGKNSRANKDKDRRRSRE----KE---------PLR 932

  Fly  1198 RKRDRSRSYERPTIRENSAPREKRMESSRSEKDSR--------RGDRSSRNERSDRGERSDRGER 1254
            |.||||:|.||                ||.|.|||        |.|:.:|:  |||.:.|.|  :
Zfish   933 RSRDRSKSRER----------------SRKEMDSRDSYGNGLERADKENRH--SDRYKESRR--K 977

  Fly  1255 SDRGER 1260
            .||..|
Zfish   978 DDRRHR 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	MIF4G	421..602	CDD:214713	134/180 (74%)
		MA3	711..817	CDD:280933	68/105 (65%)
		PHA02896	<1107..1300	CDD:165222	40/162 (25%)
cwc22	NP_001071037.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..225		82/290 (28%)
		MIF4G	258..439	CDD:214713	134/180 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..534		15/37 (41%)
		MA3	549..655	CDD:295416	68/105 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594896
Domainoid	1	1.000	222	1.000	Domainoid score	I2538
eggNOG	1	0.900	-	-		E1_KOG2140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	864	1.000	Inparanoid score	I404
OMA	1	1.010	-	-		QHG53878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002777
OrthoInspector	1	1.000	-	-		oto40429
orthoMCL	1	0.900	-	-		OOG6_101743
Panther	1	1.100	-	-	LDO	PTHR18034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R268
SonicParanoid	1	1.000	-	-		X1867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790