DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ncm and CG9004

DIOPT Version :9

Sequence 1:	NP_609877.2	Gene:	ncm / 35099	FlyBaseID:	FBgn0086707	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_647717.1	Gene:	CG9004 / 38303	FlyBaseID:	FBgn0035336	Length:	854	Species:	Drosophila melanogaster

Alignment Length:	919	Identity:	183/919 - (19%)
Similarity:	343/919 - (37%)	Gaps:	240/919 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EKRAKERDAGQDEQPTEQKKTPAAEPRSERQHISHSAGVEKQQEEAVAAAE--AESEKLNEAKKV 125
            :|.||.:...:.||   :|:....:.:::|.:.   ||.....:...||||  |...:|.:.||
  Fly     6 KKEAKAKPLTRKEQ---RKQKSEFKKQNKRLYF---AGKTNGTQRVAAAAEALAAQSQLGKNKK- 63

  Fly   126 ETPVQRKEEAEASSVTKELNSPKAQ------EENAARELEERRKDEEQPVTTNGSSKESPVEAAA 184
                  |:.::...:......||.|      :.:....::....|.|.........|....|...
  Fly    64 ------KKRSKKPKIINPDEIPKEQLLSGEIDSDDDESIDSDFSDAEVDALLPAREKMEVYEPLG 122

  Fly   185 ETVKPPTADHIEEGEITDKDEDDLPTKE--EKKAVASKSPPKETQRKQSRSPDGKRRRPRSSSRS 247
            :.||..|.     |.|..:||:.:..||  ::|.:.|||  |:.:.||.|..:
  Fly   123 KKVKKTTG-----GAIQRQDEEAVRRKELRQQKELESKS--KKQRIKQLRIEN------------ 168

  Fly   248 PSPSSRRRRRSRSKGSRTRSRSKSPIRRR--------------SNSLERRRVERQRRHEERDKRD 298
             ....|...:...|....:|:.|:.:.|:              .:..|:|:.|.::..:::.|..
  Fly   169 -EEDDREINKLEKKLKLNKSKDKNRLVRKMFNDGLDYLLDFVLDDEEEKRKWEEKQERKKKLKEQ 232

  Fly   299 EER------AKEREKRHQKGEPTSSRRRDDS------------REKKRSPERKRDRSSSTPKSKS 345
            :|:      :.|.|.:..:.||..:...|||            .|:::| |...::..:.||.|.
  Fly   233 QEKEEAGMWSDEEEDKEDRDEPMDNFSEDDSGSEGEDDDEDLTGEEEQS-EEDSEQEENAPKIKE 296

  Fly   346 SKTPRHTETTETNADNETVTEPAAKITERQRKTVDVLTSRTGGAYIPPAKLRMMQSQI--TDKSS 408
            ....|     :.:|:...:.:|           |::..|..|..||||.:..:|.:..  ::|.:
  Fly   297 DIYGR-----KRDAEGNILPDP-----------VELEASAAGQKYIPPHQRALMAASAGSSEKQA 345

  Fly   409 AAYQRIAWEALKKSIHGYINKVNVTNIAIITRELLRENIVRGRGLLSRSIIQAQAASPTFTHVYA 473
            ....|     |.|...|.:|:::..|:                                  |..|
  Fly   346 EILAR-----LLKQCKGLLNRLSEANL----------------------------------HKIA 371

  Fly   474 ALVSII---NSKFPNIGELLLKRLVIQFRRAFRRNDKMVCMSATRFIGHLVNQRVAHEILALEIL 535
            |.:..:   ||:: |:.|.|.|.:........|.|::||       ..|:|.....|..:..||.
  Fly   372 AGIEELYMKNSRY-NMNETLTKLIQEALLGYTRTNERMV-------QEHMVLLAYLHAQVGSEIG 428

  Fly   536 TLLVETPTDDSVEVAIAFLKECGMKLTEVSSKGIG------------AIFEMLRNILHE--GKL- 585
            ...::|    .||:...::|  .:...||..|.:.            .|:|:  |:|.|  |||
  Fly   429 AHFLQT----FVELFDGYVK--NIATLEVEDKQLNNLVLVLCYMYLFKIYEL--NLLMELIGKLS 485

  Fly   586 ----DKRVQYMIEVL----FQIRKD---GFK------DHQAVVPELELVEEDDQFTHLMMLDEAT 633
                :|.|:.::.:.    |::|||   .||      ..|.....||| :|:.:...::.:..|.
  Fly   486 DQLCEKSVECLLLIFQSIGFRLRKDDPLAFKTMMQKVQSQIASAPLEL-KENPRLRFMVDILNAV 549

  Fly   634 ETEDILNVFKFDDNYAEN----------EDKY--------KGLSRE-------ILGS---DDGSS 670
            :..::..:.::|...|||          .|:|        :.|.|.       |:||   .:...
  Fly   550 KNNNMQKLPQYDPELAENLRKRLKAMLKNDRYVVTLNITLEDLLRADKVGKWWIVGSAWTGNLDE 614

  Fly   671 SGSGSGSDSDSDSDGESGSDAEKKAEAGDIIDSTETNLIALRRTIYLTINSSLDYEECAHKLMKM 735
            .||.......:.|...:|..|::..|   :....:.| .|.||.|:..|.|:.||.:...|::.:
  Fly   615 MGSAKQKQDKNSSKSANGGFADQLLE---LARKQQMN-TAERRNIFCIIMSAADYVDAFEKILHL 675

  Fly   736 QLKPGQEIELCHMFLDCCAEQRTYEKFYGLLAQRFCNINKIYIPPFEEIFKDTYQTTHRLDTNRL 800
            .||..:.:  .::.:.|...::....:|..||.:||..|:.|...|:....|......:|...::
  Fly   676 SLKDQRAV--AYVIIHCALNEKRANPYYAHLALKFCQFNRKYQLAFQFASWDRINDIEKLSKPQI 738

  Fly   801 RNVSKFFAHLLFTDAISWDVLECIQLNEDDTTS---SSRIFIKIL-----------FQELAEYMG 851
            ||::.|...::....:...||:.:...:.|..|   ...:.:::|           |:.:|:
  Fly   739 RNLASFLQQVILAAGLQLSVLKVVDFMQLDKLSFYFMKEVMVRLLLANDEREIYQTFERVAK--- 800

  Fly   852 LGKLNAKLK 860
                |.||:
  Fly   801 ----NTKLQ 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	MIF4G	421..602	CDD:214713	41/206 (20%)
		MA3	711..817	CDD:280933	24/105 (23%)
		PHA02896	<1107..1300	CDD:165222
CG9004	NP_647717.1	MIF4G	352..553	CDD:280935	51/251 (20%)
CG9004	NP_647717.1	MA3	652..755	CDD:280933	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940