Protein Alignment ncm and Cwc22

DIOPT Version :10

• Sequence 1: NP_609877.2
• Gene: ncm / 35099
• FlyBaseID: FBgn0086707
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: XP_008760187.1
• Gene: Cwc22 / 362153
• RGDID: 1565385
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 967
• Identity: 466/967 - (48%)
• Similarity: 614/967 - (63%)
• Gaps: 83/967 - (8%)

  Fly   259 RSKGSRTRSRSKSPIRRRSNSLERRRVERQRRHEERDKRDEERAK-EREKR-HQKGEPTSSRRRD 321
            :......|..|.:...|||:|.|.|..|:.|...:||..|..|:. ||.:| :...:...||.||
  Rat     9 KQSSGHDRRESHNSYHRRSSSPEDRYTEQDRSPRDRDYSDYSRSDYERSRRGYSYDDSMESRSRD 73

  Fly   322 DSREKKRSPERKRDRSSSTPKSKSSKTPRHTETTETNADNETVTEPAAKITERQRKTVDVLTSRT 386
              |||:|..||..|...   :|:.|.:|.........:.:.|..||.:|   :::...|.|.:||
  Rat    74 --REKRRERERDADHRK---RSRKSPSPERRSPDRGVSQSSTQEEPTSK---KKKDEQDPLLTRT 130

  Fly   387 GGAYIPPAKLRMMQSQITDKSSAAYQRIAWEALKKSIHGYINKVNVTNIAIITRELLRENIVRGR 451
            ||||||||||||||.|||||:|.||||::||||||||:|.|||||::||:||.:|||:|||||||
  Rat   131 GGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGR 195

  Fly   452 GLLSRSIIQAQAASPTFTHVYAALVSIINSKFPNIGELLLKRLVIQFRRAFRRNDKMVCMSATRF 516
            ||||||::|||:|||.|||||||||:|||||||.||||:||||::.||:.:|||||.:|::|::|
  Rat   196 GLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKF 260

  Fly   517 IGHLVNQRVAHEILALEILTLLVETPTDDSVEVAIAFLKECGMKLTEVSSKGIGAIFEMLRNILH 581
            :.||:||.||||:|.||:||||:|.||||||||||.||||||:|||:||.:||.||||.||||||
  Rat   261 VAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILH 325

  Fly   582 EGKLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVEEDDQFTHLMMLDEATETEDILNVFKFDD 646
            |.::||||||||||:|.:||||||||..::..|:||||||||||::.|::....||:|||||.|.
  Rat   326 ESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDP 390

  Fly   647 NYAENEDKYKGLSREIL---GSDDGSSSGSGSGSDSDSDSDGESGSDAEKKAEAGDIIDSTETNL 708
            |:.|||:|||.:.:|||   .||..:...:||..|.:.|.:.|.|.: |:..:...|.|.||.||
  Rat   391 NFMENEEKYKVIKKEILDEGDSDSNTDQEAGSSEDEEEDEEEEEGEE-EEGGQKVTIHDKTEINL 454

  Fly   709 IALRRTIYLTINSSLDYEECAHKLMKMQLKPGQEIELCHMFLDCCAEQRTYEKFYGLLAQRFCNI 773
            ::.||||||.|.||||:|||||||:||:....|..|||:|.|||||:|||||||:||||.|||.:
  Rat   455 VSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCML 519

  Fly   774 NKIYIPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHLLFTDAISWD----VLECIQLNEDDTTSS 834
            .|.|:..||.|||:.|.|.|||:||:||||:|.|||||:||::.|.    |||||:|:|:.||||
  Rat   520 KKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVSNWVLECIKLSEETTTSS 584

  Fly   835 SRIFIKILFQELAEYMGLGKLNAKLKDDVLVESIAGLFPKDNPRNTRFSINFFTSIGLGGLTDDL 899
            ||||:||.||||.|||||.||||:|||:.|.....||.|:||||||||:||||||||||||||:|
  Rat   585 SRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDEL 649

  Fly   900 RRFLKNAPKSVPAINAEILANAGGNPFRDGSAPAGNTKVAPSSSSSSSSSSDTDSEDSSEEDSSS 964
            |..|||.||.:.|          ..|..:...|...:..:.|||.|.||.||:||.:||.|.||.
  Rat   650 REHLKNTPKVIVA----------QKPDAEQKKPVLTSSSSESSSGSDSSDSDSDSSESSSESSSE 704

  Fly   965 DSSSESSSSDSSSEPKKKRKRKDKDKKKSKKATKEKSKKTKNKKKKKKAEKEQEKEKEKQRKSKK 1029
            .|.|.||||.||:..|..|      ||:..||..|:..|.....:.:...:|..:|.::.::.:.
  Rat   705 ASDSSSSSSQSSASAKGSR------KKRQGKARGEEVDKLARSHQARDRRREGGREDQRHQEGRT 763

  Fly  1030 EKEKDKKRKKEEKKAAKKK---SKHRRKSQESSDSSGSEDSDKSTSESSDSSNSSSDESDAEPQA 1091
            |:.:.::.:.:..:.|..:   :||      ..|.|.....::..:.....|:...::...||:.
  Rat   764 ERARSERHRAQHSRDADWRDPPAKH------MEDRSHENSYNRVGNGREQGSHREPEDRHGEPRK 822

  Fly  1092 K--IKRQEHVEKNKFRGRTQDSDEFNLEGPGSKNRFQPNGNGQRRRDNSTGRERNRENSSYDRER 1154
            |  .:|....|..|.|.|.||||..                  ||:|.|..|||:|::|
  Rat   823 KRRERRDSFSENEKQRARNQDSDNV------------------RRKDGSKSRERSRKHS------ 863

  Fly  1155 NRGNSSYDRERKRGNSSYDRERNRESSYDKERKNRNAVAHDRQRKRDRSRSYER-PT 1210
              |:...|.:|.:..:  :|...:.|.|         ..|.|:.||.:.|..|: ||
  Rat   864 --GHKGDDDDRYQNGA--ERRWEKPSRY---------AEHSRESKRSQDRRREKSPT 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	PTZ00121	<50..>334	CDD:173412	27/76 (36%)
		MIF4G	421..602	CDD:214713	131/180 (73%)
		MA3	711..817	CDD:397128	70/105 (67%)
		PRK12678	1119..>1311	CDD:237171	23/93 (25%)
Cwc22	XP_008760187.1	U2AF_lg	9..>124	CDD:273727	35/122 (29%)
		MIF4G	165..346	CDD:214713	131/180 (73%)
		MA3	457..563	CDD:397128	70/105 (67%)
		PRK12678	733..>902	CDD:237171	43/211 (20%)
		U2AF_lg	829..>908	CDD:273727	31/116 (27%)