Protein Alignment ncm and let-858

DIOPT Version :9

• Sequence 1: NP_609877.2
• Gene: ncm / 35099
• FlyBaseID: FBgn0086707
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_496363.1
• Gene: let-858 / 174689
• WormBaseID: WBGene00002957
• Length: 897
• Species: Caenorhabditis elegans
• Alignment Length: 1077
• Identity: 427/1077 - (39%)
• Similarity: 606/1077 - (56%)
• Gaps: 194/1077 - (18%)

  Fly   137 ASSVTKELNSPKAQEENAARELEERRKDEEQPVTTNGSSKESPVEAAAETVKPPTADHIEEGEIT 201
            :||.::...:|||..|.  || ||.::..|||.|...||::|    |:.:..|
 Worm     2 SSSRSQSPETPKAASEE--RE-EEEKESSEQPDTPKTSSEKS----ASRSQSP------------ 47

  Fly   202 DKDEDDLPTKEEKKAVASKSPPKETQRKQSRSPDGKRR--RPRS-SSRSPSPSSRRRRRSRSKGS 263
                      .|.:.|:.::...|.|.|.....||..:  .|.| .||..||:.:|.:.:|
 Worm    48 ----------RESREVSQETETSENQEKIKEKDDGDDQPGTPNSYRSRETSPAPKRSKETR---- 98

  Fly   264 RTRSRSKSPIRRRSNSLERRRVERQRRHEERDKRDEERAKEREKRHQKGEPTSSRRRDDSREKKR 328
            .:.|..|||:|.|                                        |.||..:|...|
 Worm    99 ESESPEKSPVRSR----------------------------------------SPRRSSARSPSR 123

  Fly   329 SPERKRDRSSSTPKSKSSKTPRHTETTETNADNETVTEPAAKITERQRKTVDVLTSRTGGAYIPP 393
            ||.|:|:|||...:|:                     |||....:::::.:|:|.:|||||||||
 Worm   124 SPRRRRERSSERKQSE---------------------EPAPLPEKKKKEPLDILRTRTGGAYIPP 167

  Fly   394 AKLRMMQSQITDKSSAAYQRIAWEALKKSIHGYINKVNVTNIAIITRELLRENIVRGRGLLSRSI 458
            ||||:||.||:||.|..|||:.||.:||.|||.:|:||..|:..|.||||:||::|.:|||.|.|
 Worm   168 AKLRLMQQQISDKQSEQYQRMNWERMKKKIHGLVNRVNAKNLVQIVRELLQENVIRSKGLLCRDI 232

  Fly   459 IQAQAASPTFTHVYAALVSIINSKFPNIGELLLKRLVIQFRRAFRRNDKMVCMSATRFIGHLVNQ 523
            |||||.||.|::|||||.::||||||::|||||:||::||:|:|||||:.|.::..:||.||:||
 Worm   233 IQAQAFSPGFSNVYAALAAVINSKFPHVGELLLRRLIVQFKRSFRRNDRGVTVNVIKFIAHLINQ 297

  Fly   524 RVAHEILALEILTLLVETPTDDSVEVAIAFLKECGMKLTEVSSKGIGAIFEMLRNIL-----HEG 583
            :||||:|||||:.|::|.|||||||||||||||||.||.|::...:.::::.||.||     .|.
 Worm   298 QVAHEVLALEIMILMLEEPTDDSVEVAIAFLKECGAKLLEIAPAALNSVYDRLRAILMETERSEN 362

  Fly   584 KLDKRVQYMIEVLFQIRKDGFKDHQAVVPELELVEEDDQFTHLMMLDEATETEDILNVFKFDDNY 648
            .||:|:|||||...|||||.|..:.||:.:|:|:||:||..|.:.|::|.:.|:.|||||.|..:
 Worm   363 ALDRRIQYMIETAMQIRKDKFAAYPAVIEDLDLIEEEDQIIHTLNLEDAVDPENGLNVFKLDPEF 427

  Fly   649 AENEDKYKGLSREILGSDDGSSSGSGSGSDSDSDSDGESGSDAEK-KAEAGDIIDSTETNLIALR 712
            .:||:.|:.:.:||:|:.|.|....|     |...|.|.|||.|: ..:..:|||:|:.||.|.|
 Worm   428 EKNEEVYEEIRKEIIGNADISDEDGG-----DELDDEEEGSDVEEAPKKTTEIIDNTDQNLTAFR 487

  Fly   713 RTIYLTINSSLDYEECAHKLMKMQLKPGQEIELCHMFLDCCAEQRTYEKFYGLLAQRFCNINKIY 777
            |.:|||:.|||||:|.||||:||::....:.|||.|.:||||:|||||:|||:|.:|||.:...|
 Worm   488 REVYLTMQSSLDYQEAAHKLLKMKIPDSMQNELCAMLVDCCAQQRTYERFYGMLIERFCRLRLEY 552

  Fly   778 IPPFEEIFKDTYQTTHRLDTNRLRNVSKFFAHLLFTDAISWDVLECIQLNEDDTTSSSRIFIKIL 842
            ...||::.:|||.|.||:|..:|||:::..||||.||||.|.:|..:::.|:|||||.||:||.:
 Worm   553 QQYFEKLCQDTYSTIHRIDITKLRNLARLIAHLLSTDAIDWKILADMKMTEEDTTSSGRIYIKYI 617

  Fly   843 FQELAEYMGLGKLNAKLKDDVLVESIAGLFPKDNPRNTRFSINFFTSIGLGGLTDDLRRFLKNAP 907
            |.||.|.||:.||::::.|..|.....||||:.||.:.||||||||.|||||||.:||.:|....
 Worm   618 FNELVEAMGMVKLHSRVTDPTLAHCFVGLFPRTNPNSARFSINFFTMIGLGGLTLELREWLAKGL 682

  Fly   908 KSVPAINAEILANAGGNPFRDGSAPAGNTKVAPSSSSSSSSSSDTDSEDSSEEDSSSDSSSESSS 972
            |....:..::.|.                    |||.|||||..:||.|||:.|.||||||:|||
 Worm   683 KKKKGMLDQLKAE--------------------SSSDSSSSSDSSDSSDSSDSDDSSDSSSDSSS 727

  Fly   973 SDSSSEPKKKRKRKDKDKKKSKKATKEKSKKTKNKKKKKKAEKEQEKEKEKQRKSKKEKEKDKKR 1037
            | |.|||:..                        ||||||..:|..|:|||:...:::: .||:.
 Worm   728 S-SESEPEPP------------------------KKKKKKNSEESSKKKEKENIGRRDR-GDKRA 766

  Fly  1038 KKEEKKAAKKKSKHRRKSQESSDSSGSEDSDKSTSESSDSSNSSSDESDAEPQAKIKRQEHVEKN 1102
            ::...::.:.|.|.||:.|:|.::...|..|.....|.|.....||:.|               .
 Worm   767 ERHRDQSVENKDKDRRRRQDSDENRRPERGDDRKDRSKDRRRQDSDDED---------------R 816

  Fly  1103 KFRGRTQDSDEFNLEGPGSKNRFQPNGNGQRRRDNSTGRERNRENSSYDRERNRGNSSYDRE--- 1164
            |.|.|.:||                   |:|||.:...|:||::..  |...:|.:.|.|||
 Worm   817 KGRERREDS-------------------GERRRGDRDRRDRNKDQE--DHREDRRDRSKDREDRR 860

  Fly  1165 -RKRGNSSYDRERNRESSYDKERKNRNAVAHDRQRKR 1200
             |:|.:|..||:..|:.|.::..:.|...:.||:|:|
 Worm   861 DRRRHDSDDDRKTRRDRSEERGGRRREVESDDRRRRR 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ncm	NP_609877.2	MIF4G	421..602	CDD:214713	109/185 (59%)
		MA3	711..817	CDD:280933	57/105 (54%)
		PHA02896	<1107..1300	CDD:165222	28/98 (29%)
let-858	NP_496363.1	MIF4G	195..382	CDD:214713	110/186 (59%)
		MA3	486..592	CDD:280933	57/105 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166451
Domainoid	1	1.000	192	1.000	Domainoid score	I1899
eggNOG	1	0.900	-	-		E1_KOG2140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	723	1.000	Inparanoid score	I324
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002777
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101743
Panther	1	1.100	-	-	LDO	PTHR18034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R268
SonicParanoid	1	1.000	-	-		X1867
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.830