Protein Alignment Fas3 and nphs1

DIOPT Version :10

• Sequence 1: NP_001097174.1
• Gene: Fas3 / 35097
• FlyBaseID: FBgn0000636
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: XP_073779348.1
• Gene: nphs1 / 692352
• ZFINID: ZDB-GENE-051102-1
• Length: 1287
• Species: Danio rerio
• Alignment Length: 580
• Identity: 113/580 - (19%)
• Similarity: 186/580 - (32%)
• Gaps: 186/580 - (32%)

  Fly    25 EPNTALLNEGDRTELLCRYGRSI-------------------NYCRIEIPGEQKVLNLSPEWSKT 70
            ||....:..|....|.|...|:.                   .|.|..:.|:||
Zfish    77 EPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLGPLRSLPGYPRYSMTGDQK----------- 130

  Fly    71 PGFTYFGAGLTAGQCGVSIERVKASNNGQVKCSLGVEGEE---LSGTIDLVVALRPQQPIIELLS 132
                       .||..:.|..|...::|..:|.:|.....   :|.|:.|.|.:...||..:|.|
Zfish   131 -----------KGQYHLQILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLES 184

  Fly   133 RPNREGYFNEGTEFRARCSVRDGRPPANISWYIDN---MPANKRTTPLEVMSSTNDNVELSTSVQ 194
                |..:.||.::...|...|.:|||.|:.:.|.   :.:...|     ||.:.|  :|..:..
Zfish   185 ----EEPWVEGEQYTVTCIAPDAKPPAEITMFRDGEELLESESYT-----MSGSQD--KLQNTHA 238

  Fly   195 EIQWHLSPEDSNRKLVCRSHHQTDRESVPPQEAAYIINVRYAPVHQPDAAVYGLYLEHT------ 253
            |:.......|..|:|.||:.:.....::   |....:.| |.|...|  .:.||..|..
Zfish   239 EVTIRARSSDDTRRLTCRAKNPASPRAL---ETGMTMKV-YFPPQAP--MIMGLENEEVKAGSFL 297

  Fly   254 AIVNITIRASPQPKIEWTIDGAIVG------------------QGRTDGRYSAYEPQYLGNDEYN 300
            .:|.::...:|...:.||.:|.::.                  :.:.:..::..:.|.:.    .
Zfish   298 KVVCMSYGGNPLATLHWTKNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAVLQCQSIN----Q 358

  Fly   301 VTLAIAGLTLEDTTKIYNLRASNELG----LTDYQVRIS---SSSKPPSSSLDVAAIVGIVVAVA 358
            ||.:...|| ...|.::.......||    :...::.:|   |||.||         |.|
Zfish   359 VTRSPMSLT-RTLTVLFEPAEVTLLGSFEAVEGEEINLSCSTSSSNPP---------VHI----- 408

  Fly   359 VLVLVVLLIVFARATGRWCFGGKSIKTPTNETQIDKQLELGAQQNHGQNVALLETPNGITLLGAS 423
                            ||..|.|.:    |.|:                |...|..||..:..::
Zfish   409 ----------------RWWLGFKEL----NRTE----------------VTFAEGDNGGMMTVSN 437

  Fly   424 KLREVNGNGNGNGQQDRLSVERRHHDEDDSFEYGTDRESSVYNPTTRPLKSILMSQAAGRNSRSS 488
            ...:|:...||      ||::....::...|......|..||.|   |.|..|
Zfish   438 LTHKVSREDNG------LSLQCEAFNKGTRFSSVRAAELIVYYP---PQKVWL------------ 481

  Fly   489 ASDKDEGNENADLLQKGNQL--------GIPESRFSRWLPKDQRELIEKQAMLLSGRGKS 540
                |....|. .|..|:.|        |.|..:.: || |:.:.::.....:.|.||.|
Zfish   482 ----DAPPPNV-FLHSGSTLRLVCFSSGGNPTGQLT-WL-KNNKVVLTASKQVSSERGVS 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fas3	NP_001097174.1	C2-set_2	141..222	CDD:400489	20/83 (24%)
		Ig strand B	146..150	CDD:409353	0/3 (0%)
		Ig strand C	160..164	CDD:409353	1/3 (33%)
		Ig strand E	194..198	CDD:409353	1/3 (33%)
		Ig strand F	208..213	CDD:409353	2/4 (50%)
		Ig strand G	226..229	CDD:409353	1/2 (50%)
		Ig	253..326	CDD:472250	11/96 (11%)
nphs1	XP_073779348.1	None