DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5790 and CDC7

DIOPT Version :9

Sequence 1:	NP_001286037.1	Gene:	CG5790 / 35095	FlyBaseID:	FBgn0032677	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_010267.3	Gene:	CDC7 / 851545	SGDID:	S000002175	Length:	507	Species:	Saccharomyces cerevisiae

Alignment Length:	544	Identity:	143/544 - (26%)
Similarity:	223/544 - (40%)	Gaps:	128/544 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 MQSVDKN--------EEALKELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQRERGLVETQRRR 177
            |.|..||        :|.:.:|...:|.|...:.:..:||.||||:|     .:.:.:.....::
Yeast     1 MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSV-----YKAKDITGKITKK 60

  Fly   178 F------------AIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTH 230
            |            |:|....|:.|:||..||..:|.:.|...|..:....|..|.|..::||..|
Yeast    61 FASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPH 125

  Fly   231 DRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIA 295
            :.|...||.|....|:.|:..||.||:.||...:||||:||:|.|:|...|:.:|.|||||:...
Yeast   126 EEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQM 190

  Fly   296 DDGSVVQSSDLSSREVFSILRDLENGRSVTLTDGNSAQAEAEDYMARRRMRALGGGGSVERAVTG 360
            |..|::.|.:           |.:|..: |..||..:....|.:.
Yeast   191 DYKSMISSQN-----------DYDNYAN-TNHDGGYSMRNHEQFC-------------------- 223

  Fly   361 PPSIQKLREQAGGHLTKKDVANQRADTMRLLNR--LRLVSPNADPNNYVVSTNTSKKEMHASRAG 423
             |.|.:.:.....|       ||....:.:.|.  :.|.:.|..........|.:::...|:|||
Yeast   224 -PCIMRNQYSPNSH-------NQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAG 280

  Fly   424 TPGYRPPEVLLRYPKQSTAVDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTA 488
            |.|:|.||||::...|||.:|:|:.|||:||||....|.|::..|..:|.|:..:||...:||.|
Yeast   281 TRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCA 345

  Fly   489 FL----LDRLILLAQKVNTLD----------LRRVCMRFRHADF--------FLAPEIQRKY--- 528
            .|    .:...|:..|.|...          |.:.|......::        ||..|:..:.
Yeast   346 ALHGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIE 410

  Fly   529 -QRPDGTTEMCRSCEQPTFNCLCSNSGHNLERYDGLDIFPAVAY------------DLLSRLLEV 580
             |.||..|.|                       |.:|.:....|            .:|.:..|:
Yeast   411 PQLPDPKTNM-----------------------DAVDAYELKKYQEEIWSDHYWCFQVLEQCFEM 452

  Fly   581 NPQKRITAEEALKHPFFSDQHRIT 604
            :||||.:||:.||.|||::.:..|
Yeast   453 DPQKRSSAEDLLKTPFFNELNENT 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	132/505 (26%)
		S_TKc	145..597	CDD:214567	132/503 (26%)
		PKc_like	<238..>363	CDD:304357	35/124 (28%)
		PKc_like	<364..>462	CDD:304357	31/99 (31%)
		PKc_like	<427..597	CDD:304357	55/207 (27%)
CDC7	NP_010267.3	STKc_Cdc7	31..348	CDD:270921	104/361 (29%)
CDC7	NP_010267.3	PKc_like	<443..476	CDD:419665	13/32 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346077
Domainoid	1	1.000	91	1.000	Domainoid score	I1752
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H117767
Inparanoid	1	1.050	172	1.000	Inparanoid score	I1000
Isobase	1	0.950	-	0	Normalized mean entropy	S4005
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		otm46771
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
TreeFam	1	0.960	-	-
	15	14.730