Protein Alignment CG5790 and CDC7

DIOPT Version :9

• Sequence 1: NP_001286037.1
• Gene: CG5790 / 35095
• FlyBaseID: FBgn0032677
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001127891.1
• Gene: CDC7 / 8317
• HGNCID: 1745
• Length: 574
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 193/563 - (34%)
• Similarity: 288/563 - (51%)
• Gaps: 104/563 - (18%)

  Fly   123 SVDKNEEALK---------ELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQRERGLVETQRRRF 178
            |:.|||:..|         :|.|::|:::.:|.:..:||.||||:|.|.|.|.:.|..|    :.
Human    27 SLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEE----KI 87

  Fly   179 AIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTHDRFHDIYRSLNFP 243
            |:||..||:||.||..||:|:...||.:||:|:..|.|.||:|...|||:.|:.|.||..||:|.
Human    88 ALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQ 152

  Fly   244 EIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQ---------------- 292
            |:|:|:.||..||:.:|:|.::||||||||.|||||..|:.|.||||||
Human   153 EVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSE 217

  Fly   293 -----------------RIADDGSVVQSSDLSSREVFSILRDLENGRSVTLTDGNSAQAEAEDYM 340
                             :|...|.|.:..|..|....|:.|...|.: :.:..|...:..:.
Human   218 AQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQ-IQIKQGKDGKEGSV--- 278

  Fly   341 ARRRMRALGGGGSVERAVTG-------------PPSIQKLRE-QAGGHLTKKDVANQRADTMRLL 391
                      |.||:|:|.|             .|:::.::: :....|::|....::|.:.:::
Human   279 ----------GLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVM 333

  Fly   392 NR--LRLVSPNADPN--------NYVVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVW 446
            |.  :|..:.:...:        :.|.|...|:::..|.||||||:|.||||.:.|.|:||:|:|
Human   334 NSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMW 398

  Fly   447 AAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLAQKVNTLDLRRVCM 511
            :||||.||||||.:||:||..|..|||:|:.:.|.....:.|....:.||.:::|...|||::|.
Human   399 SAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCE 463

  Fly   512 RFRHADFF---LAPEIQRKYQRPDGTTEMC---RSC--EQP-------TFNCLCSNS-GHNLERY 560
            |.|..|..   |..:||.........:|..   .||  :.|       :|....||| .|..:.|
Human   464 RLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEY 528

  Fly   561 ----DGLDIFPAVAYDLLSRLLEVNPQKRITAEEALKHPFFSD 599
                :|.:..|..|||||.:||::||..||||||||.||||.|
Human   529 NTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	182/530 (34%)
		S_TKc	145..597	CDD:214567	182/528 (34%)
		PKc_like	<238..>363	CDD:304357	48/170 (28%)
		PKc_like	<364..>462	CDD:304357	36/108 (33%)
		PKc_like	<427..597	CDD:304357	76/189 (40%)
CDC7	NP_001127891.1	STKc_Cdc7	56..438	CDD:270921	137/399 (34%)
		PKc_like	<293..>419	CDD:328722	41/125 (33%)
		PKc_like	<358..571	CDD:328722	88/212 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158793
Domainoid	1	1.000	154	1.000	Domainoid score	I4261
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2842
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60149
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		oto91354
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800