DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5790 and cdc7

DIOPT Version :9

Sequence 1:	NP_001286037.1	Gene:	CG5790 / 35095	FlyBaseID:	FBgn0032677	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_005171217.1	Gene:	cdc7 / 492768	ZFINID:	ZDB-GENE-041114-113	Length:	549	Species:	Danio rerio

Alignment Length:	551	Identity:	194/551 - (35%)
Similarity:	284/551 - (51%)	Gaps:	68/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 KELSTIQAKDMQSVDKN----------EEALKELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQ 165
            :|.:|:|....:||:|.          |..:..|.|.:|::::||.:..:||.||||:|.|...|
Zfish     2 EEANTVQRSSHRSVEKGRSRHKISRDVETEIAYLYEVLPQLSRIFRIIDKIGEGTFSSVYLAEAQ 66

  Fly   166 RERGLVETQRRRFAIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTH 230
                :.::.||.||:||..||:||.||..||:|:...||.|||:|:..|.|...:|..:||||.|
Zfish    67 ----MTDSSRRLFALKHLIPTSHPVRIAAELQCLTVAGGTENVMGVTYCFRKEHHVVIVMPYMEH 127

  Fly   231 DRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIA 295
            ..|.||...|:|.::|.|:.:||.||:|:|||.:||||:||:|.|:||:..::.|.||||||...
Zfish   128 QTFVDIVGLLSFEDVRHYIYHLLKALKHIHKFGIIHRDIKPTNFLFNRQKREYALVDFGLAQGTP 192

  Fly   296 DDG----SVVQSSDL----SSREVFSILRDLE------NGRSVTLTDGNSAQAEAEDYMAR-RRM 345
            |..    .||:|...    ||:.|...|...:      |.|:..:.....|.|:.....:| :..
Zfish   193 DTQIELLKVVKSKGHKGGGSSKMVEESLGKQKLVPLPPNSRNPAVQSSTKAPAKRPCPPSRVKHS 257

  Fly   346 RALGGGGSVERAVTGPPSIQKLR------EQAGGHLT---KKDV-------ANQRADTMRL-LNR 393
            :.|.|.....|:|.|..||....      ::..|.|:   |::|       |..|:..:|. ||:
Zfish   258 KELMGLDKAPRSVFGEKSINSTNSHKPGSDKVEGLLSKPKKEEVIPRKIVSAKHRSVPVRAPLNQ 322

  Fly   394 LR------------LVSPNADPNNY----VVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTA 442
            .:            .|:|....|.|    |.:...|:|:..|.||||||:|.||||.:.|.|.||
Zfish   323 KQKLPAESQKPKPAAVNPLLTCNCYMTDRVCNICLSRKQQVAPRAGTPGFRAPEVLTKCPNQGTA 387

  Fly   443 VDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLAQKVNTLDLR 507
            :|:|:||||:||||||.:|||||..|..||.:|:.:.|.....:.|....:.|:.::::..||||
Zfish   388 IDMWSAGVILLSLLSGRYPFFKANDDLIALTQIMTIRGSKETIEAAKTFGKSIVCSRELPRLDLR 452

  Fly   508 RVCMRFRHADFFLAPEIQRKYQRPDGTTEMCRSCEQP----TFNCLCSNSGHNLERYDGLDIFPA 568
            .:|...|....:....:..::|......|.....|.|    |.:.||.:|....|  .|.|..|.
Zfish   453 ILCETLRGLRSWDDASLPAEFQASHNPAEEKEEAESPALKSTGSRLCRSSAELKE--IGWDRVPD 515

  Fly   569 VAYDLLSRLLEVNPQKRITAEEALKHPFFSD 599
            ..||||.:||::||..||||..||:||.|.|
Zfish   516 EVYDLLDKLLDLNPATRITASTALQHPLFKD 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	182/505 (36%)
		S_TKc	145..597	CDD:214567	181/503 (36%)
		PKc_like	<238..>363	CDD:304357	47/139 (34%)
		PKc_like	<364..>462	CDD:304357	45/130 (35%)
		PKc_like	<427..597	CDD:304357	67/173 (39%)
cdc7	XP_005171217.1	STKc_Cdc7	45..431	CDD:270921	146/389 (38%)
cdc7	XP_005171217.1	PKc_like	<332..513	CDD:304357	64/182 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594734
Domainoid	1	1.000	160	1.000	Domainoid score	I4027
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2736
OMA	1	1.010	-	-		QHG60149
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		oto39335
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800