DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5790 and spo4

DIOPT Version :9

Sequence 1:	NP_001286037.1	Gene:	CG5790 / 35095	FlyBaseID:	FBgn0032677	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_596598.1	Gene:	spo4 / 2540745	PomBaseID:	SPBC21C3.18	Length:	429	Species:	Schizosaccharomyces pombe

Alignment Length:	518	Identity:	135/518 - (26%)
Similarity:	210/518 - (40%)	Gaps:	157/518 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 STIQAKDMQSVDKNEEALKELQESIPEINKIFDVHCRIGSGTFSTVLLG--------------TL 164
            |.:.|.|:...|:.|  :.:|.::.|.|.:.:.|...:|:|:||:|...              :.
pombe    11 SGVYASDVDREDRPE--IAKLVQAFPTIEEDYHVVKLVGAGSFSSVFKAVDRHFDSYDNSYWISS 73

  Fly   165 QRERGLVETQRRRFAIKHHNPTNH------------PERILRELECMYRIGGVENVIGINCCIRY 217
            |.|..:...:.:|       |.||            |.||..|||.::.:.|.:.|:.:...:|:
pombe    74 QIEDQMPHDKTKR-------PKNHFVALKRIYATVLPSRIQTELEMLHELRGSDCVLNMITAVRH 131

  Fly   218 NDNVAFIMPYMTHDRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGK 282
            .|.|..::|::.|..|.|.|...:.|||..|||:||..|.|:....:||||:||.|..:|..|.:
pombe   132 QDQVLIVLPFIQHAEFRDFYMKYSLPEIGAYLRDLLKGLAHIDAKGIIHRDIKPGNFAWNPYTQR 196

  Fly   283 FLLCDFGLAQRIADDGSVVQSSDLSSRE-VFSILRDLENGRSVTLTDGNSAQAEAEDYMARRRMR 346
            .::.||||||        .|.:|..:.. ....||.|:.            :.:..||.
pombe   197 GVILDFGLAQ--------WQEADAPTENCCVDKLRKLKQ------------EGKYYDYF------ 235

  Fly   347 ALGGGGSVERAVTGPPSIQKLREQAGGHLTKKDVANQRADTMRLLNRLRLVSPNADPNNYVVSTN 411
                  ..|:.:..||.         |:|.......:|||
pombe   236 ------PFEKTIADPPE---------GYLLHDPRPTKRAD------------------------- 260

  Fly   412 TSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEII 476
                     ||||.|:|.||||.|...|::::|||:.|||:|..|:..:|||:...|..|:.|:.
pombe   261 ---------RAGTRGFRAPEVLFRCQNQTSSIDVWSVGVILLCFLTHRYPFFRCEDDIDAIVELA 316

  Fly   477 NLFGDMPVRKTAFLLDRL------ILLAQKVNTLDLRRVCMRFRHADFFLAPEIQRKYQRPDGTT 535
            ::||...:...|.|..::      .||.||.|.|||             :|.
pombe   317 HIFGRNGMSNCALLHGQIWSDNIPTLLDQKHNWLDL-------------IAS------------- 355

  Fly   536 EMCRSCEQPTFNCLCSNSGHNLERYDGLDIFPAVAYDLLSRLLEVNPQKRITAEEALKHPFFS 598
                          .:.:..||......|...|:|.|||.:|||::|.||:.|:.||:|.||:
pombe   356 --------------ITKNDENLILETSSDYQVALAIDLLDKLLELHPSKRVKAKTALQHEFFN 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	125/486 (26%)
		S_TKc	145..597	CDD:214567	125/484 (26%)
		PKc_like	<238..>363	CDD:304357	34/125 (27%)
		PKc_like	<364..>462	CDD:304357	25/97 (26%)
		PKc_like	<427..597	CDD:304357	52/175 (30%)
spo4	NP_596598.1	STKc_Cdc7	38..403	CDD:270921	125/486 (26%)
spo4	NP_596598.1	S_TKc	40..403	CDD:214567	125/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2008
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I1078
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		mtm9301
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2064
SonicParanoid	1	1.000	-	-		X2628
TreeFam	1	0.960	-	-
	12	11.850