DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5790 and cdc-7

DIOPT Version :9

Sequence 1:	NP_001286037.1	Gene:	CG5790 / 35095	FlyBaseID:	FBgn0032677	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_491705.1	Gene:	cdc-7 / 172260	WormBaseID:	WBGene00016421	Length:	411	Species:	Caenorhabditis elegans

Alignment Length:	489	Identity:	122/489 - (24%)
Similarity:	185/489 - (37%)	Gaps:	157/489 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQRERGLVETQRRRFAIKHHNPTNHPERILRELE 197
            :|||:|            ||.|:|.||:..|.:      .||.:| |||..........:..|||
Worm    28 QLQENI------------IGEGSFGTVISATCR------TTQEKR-AIKAIRRIEKMSMLSIELE 73

  Fly   198 CMYRIGGVENVIGINCCIRYNDNVAFIMPYMTHDR-----FHDIYRSLNFPEIRDYLRNLLIALR 257
            .:..:||..|::.:.....:|.:||.::.:..|..     ||. .|.|:|  ...|.||||.|:.
Worm    74 LLSELGGHFNIVKLFEFFHFNGSVAIVLEHFPHCTATELLFHS-KRDLSF--ALSYFRNLLYAVA 135

  Fly   258 HVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIADDGSVVQSSDLSSRE--VFSILRDLEN 320
            ::|....:|||:|.||.||:.:|.:|.|.|||||       :|.:|.:..||.  |.::.||.|
Worm   136 YLHHNGYVHRDIKLSNFLYSPQTQRFRLVDFGLA-------TVDRSKNECSRSHAVAAMERDPE- 192

  Fly   321 GRSVTLTDGNSAQAEAEDYMARRRMRALGGGGSVERAVTGPPSIQKLREQAGGHLTKKDVANQRA 385
                    ..|.:..:...|..|                |.|.    ||
Worm   193 --------CCSCKGTSSPCMFCR----------------GKPK----RE---------------- 213

  Fly   386 DTMRLLNRLRLVSPNADPNNYVVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGV 450
                               ||.|             .||||.|.||:|........::|:::.|:
Worm   214 -------------------NYNV-------------VGTPGVRAPELLFGIGLCHPSIDIFSCGI 246

  Fly   451 IMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLAQKVNTLDLRR--VCMRF 513
            ::|||:|..||||....:...:..:..|.|...:.|.|......:.|::|:...|...  :|:||
Worm   247 VLLSLVSVKHPFFMPKDETENIMHLAFLLGSETIEKMAHSEGLRVTLSEKLPPADYYHLILCLRF 311

  Fly   514 ------RHADFFLAPEIQRKYQRPDGTTEMCRSCEQPTFN-----CLC---------SNSGHNLE 558
                  ||.               ..:.:.|..|::.:||     |.|         |..|:..|
Worm   312 GFDHVRRHC---------------SSSRQPCTICQKRSFNNSMGVCFCRKNYETDMFSTGGNETE 361

  Fly   559 RYDGLDIFPAVAYDLLSRLLEVNPQKRITAEEAL 592
                   ...:..|||.|.||.:..||..|::.|
Worm   362 -------LMTIYVDLLYRTLEADRFKRYNADQLL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5790	NP_001286037.1	STKc_Cdc7	143..597	CDD:270921	118/479 (25%)
		S_TKc	145..597	CDD:214567	118/477 (25%)
		PKc_like	<238..>363	CDD:304357	38/126 (30%)
		PKc_like	<364..>462	CDD:304357	20/97 (21%)
		PKc_like	<427..597	CDD:304357	45/188 (24%)
cdc-7	NP_491705.1	PKc_like	34..277	CDD:389743	88/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I3181
Isobase	1	0.950	-	0	Normalized mean entropy	S4005
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700