DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp36E and PTP3

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_010998.2	Gene:	PTP3 / 856807	SGDID:	S000000877	Length:	928	Species:	Saccharomyces cerevisiae

Alignment Length:	563	Identity:	116/563 - (20%)
Similarity:	204/563 - (36%)	Gaps:	195/563 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TGKHRSRSSARYDDVEKQQRKS----------RAIVSIPNTIKLSMLNSGLLSFERIK-LEARDE 70
            |.|.:.....||:::.|...|.          :.::|||   |:.:::    .|:::. ||.|..
Yeast   385 TNKDKLGFQIRYENLSKNYEKEVIDSVIPEWFQHLMSIP---KIELVS----QFQKLDFLEKRRL 442

  Fly    71 NNSLS----------KTIPNGPIDIRHFLKLCDLRRKFPVLYKLE--------------FQTAAK 111
            |:|:|          :...:.|..:........:..|||.:.|::              :::...
Yeast   443 NHSVSFRKKENSFILEKPSSYPEQLTSTSSSTIMPPKFPDVNKVQKRSHSQPIFTQYSKYKSMLS 507

  Fly   112 VESNTCRHA---LKKNNLE---KNQNPKCIPYDYNRVVLEKVGGLQDS----------------D 154
            :||::...:   :..:.:|   ||:.....||:::||:|:|  |||.|                :
Yeast   508 LESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKK--GLQSSKGIKHSHSTSDGGILDN 570

  Fly   155 YVNASYVDSL----LKPNA-------------YIVTQGPVEETVQAYWRMVWQENISAIVMLTKT 202
            |:||:|: ||    ::.|:             ||.||.|:..||..::..:....:..::.||..
Yeast   571 YINANYL-SLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTND 634

  Fly   203 FDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFR----------LYKM----NEK 253
            |:.....|::||...     .|..|.:.::.::.|......:.|          ||..    |..
Yeast   635 FENGIEKCYRYWQEG-----NYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSS 694

  Fly   254 QEVTD-------------------------------------ERLILQFHYTE------------ 269
            ...||                                     .:::|.:|..|
Yeast   695 NYSTDNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAILIRKILLTYHDQEKPYELLQIQVKN 759

  Fly   270 WYSHSCPFSNALLEFRRRVRLV-VGNIIKD--------EDDMRGPILVHCSDGGGRSGVYMSID- 324
            |     |....||.....::.: |.|.|.|        ::|....||||||.|.||:|...:||
Yeast   760 W-----PDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDS 819

  Fly   325 --ANLELAE--EEECFNVFGYLKKL-----------RQSRKGLVENVEQYKFIYDTLEEHIICGK 374
              :|.|:.|  ::| |....|..||           |:.|..:|:|:.|:.||||       |..
Yeast   820 ILSNFEMFEMLQKE-FVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFIYD-------CLL 876

  Fly   375 TWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTI 417
            .:|.:     ||.....|..|...|:.......:.:|..:..|
Yeast   877 FYFRL-----RLDDITERTDGDGSNKDNISLSALIEQIEKLEI 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	83/366 (23%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
PTP3	NP_010998.2	DSP_MapKP	97..231	CDD:238723
PTP3	NP_010998.2	PTP_fungal	571..873	CDD:350509	68/313 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100