DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and PTP2

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_014851.3	Gene:	PTP2 / 854383	SGDID:	S000005734	Length:	750	Species:	Saccharomyces cerevisiae

Alignment Length:	508	Identity:	96/508 - (18%)
Similarity:	173/508 - (34%)	Gaps:	190/508 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VSIP-----NTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVL 101
            ::||     |.|.|..|...|:.:....|:...:.|..:...||..| :.::||.|.::....|:
Yeast   234 INIPPPNDSNKIFLQSLKKDLIHYSPNSLQKFFQFNMPADLAPNDTI-LPNWLKFCSVKENEKVI 297

  Fly   102 YKL---EFQTAAKVESNTCRHALK----------------------------------------K 123
            .|.   .|:|....|.......||                                        |
Yeast   298 LKKLFNNFETLENFEMQRLEKCLKFKKKPLHQKQLSQKQRGPQSTDDSKLYSLTSLQRQYKSSLK 362

  Fly   124 NNLEKNQNPKCI--------------------------------------------PYDYNRVVL 144
            :|::|||..|.|                                            ||:::||.|
Yeast   363 SNIQKNQKLKLIIPKNNTSSSPSPLSSDDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKL 427

  Fly   145 -----------------------------EKVGGLQDSDYVNASYVD-SLLKPN-AYIVTQGPVE 178
                                         .|....:.:||:||:|:. :.:.|: .||.||.|:.
Yeast   428 PHSPKPPAVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANYLKLTQINPDFKYIATQAPLP 492

  Fly   179 ETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVRE-EQLANFH- 241
            .|:..:|:::....:..|:.|....:........|| .|:    .|.:..|.:... |.:.|.:
Yeast   493 STMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYW-NNL----SYSNHTIKLQNTWENICNING 552

  Fly   242 --IRTFRLYKM-----NEKQE---------------VTDERLILQFHYTEWYSHSCPFS-NALLE 283
              :|.|::.|.     |..|:               |::..::.|..|..|.. ||... |.:::
Yeast   553 CVLRVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLD-SCGVDMNDIIK 616

  Fly   284 FRRRVRLVVGN----------------IIKDEDD-------MRGPILVHCSDGGGRSGVYMSIDA 325
            ..:....::.|                :|.|.:.       ...|:|||||.|.||:||::::|.
Yeast   617 LHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDF 681

  Fly   326 NLEL-------AEEEECFN-----VFGYLKKLRQSRKGLVENVEQYKFIYDTL 366
            .|.:       :.:.:.:|     :|..:.:||:.|..:|:|:.||...|:.|
Yeast   682 LLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEAL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	73/377 (19%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
PTP2	NP_014851.3	COG5599	344..748	CDD:227886	74/397 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100