DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and ptprfb

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_009296732.1	Gene:	ptprfb / 799867	ZFINID:	ZDB-GENE-060503-530	Length:	1927	Species:	Danio rerio

Alignment Length:	665	Identity:	200/665 - (30%)
Similarity:	332/665 - (49%)	Gaps:	66/665 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGPIDIRHFLKLCD---- 93
            ||:||..:  .:|.......:...||:.....:|.|..|........:.||.:.   :|.|
Zfish  1304 KQERKRAS--PLPKDDHSGGVKDCLLASSSDPVEMRRLNYQTPGMREHPPISVS---ELADHIER 1363

  Fly    94 LRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNA 158
            |:....:.:..|:::....:..|..::..:.|..||:....|.||::||||..|.|:..|||:|:
Zfish  1364 LKANDALRFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYINS 1428

  Fly   159 SYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQ 223
            :|:|...|.||||.||||:.||:..:|||:|::..|.|||:|:..:.::|.|.||||  :...|.
Zfish  1429 NYIDGYRKQNAYIATQGPLPETLSDFWRMIWEQRASTIVMMTRLEEKSRVKCDQYWP--IRGTET 1491

  Fly   224 YGDIFINIVREEQLANFHIRTFRLYK--MNEKQEVTDERLILQFHYTEWYSHSCP-FSNALLEFR 285
            ||.|.:.::...:||.:.:|||.|||  .:||:||.      ||.:..|..|..| :...:|.|.
Zfish  1492 YGMIQVTMLDAVELATYSVRTFALYKNGSSEKREVR------QFQFMAWPDHGVPEYPTPILAFL 1550

  Fly   286 RRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRK 350
            |||:..      :..| .||::||||.|.||:|.::.|||.||..:.|:..:::|::..:|..|.
Zfish  1551 RRVKAC------NPPD-AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRN 1608

  Fly   351 GLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICK---QT 412
            .:|:..:||.||::.|.|...||.|..|...|...::...:.::|..:...:.|:.::..   .|
Zfish  1609 YMVQTEDQYIFIHEALLEAATCGNTEVPARNLYAHIQKLTQPSAGETVTAMELEFKRLANSKAHT 1673

  Fly   413 PRFTIGD--CAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIV 475
            .||...:  |       |:.|||.|..:|.::.|..|...:|...:||||:..:|||.:.:.||.
Zfish  1674 SRFISANLPC-------NKFKNRLVNIMPFESTRVCLQPIRGVEGSDYINASCIDGYRQQKAYIA 1731

  Fly   476 TEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWP-NKSKMEKYGPVFSVHYVMSKS 538
            |:.|:..|..:||.::::...:.||:|.:..... ::...:|| .:|...:|      ..|...:
Zfish  1732 TQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQY------FVVDPMA 1790

  Fly   539 YTNIKQW---EFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEI 600
            ..|:.|:   |||:       |:...|   .:||::.||.|.|| ...||.:....:..:..|.
Zfish  1791 EYNMPQYILREFKV-------TDARDG---QSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVH- 1843

  Fly   601 WRNKVDY---GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTE 662
             :.|..:   ||:.|....|..|.||:...:..:|::...|.||:||.|||:|..||.:|:...:
Zfish  1844 -KTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDLFQTVKTLRTQRPAMVQTEDQ 1907

  Fly   663 YKYCYDLVLHYVLHF 677
            |:.||...|.|:..|
Zfish  1908 YQLCYRAALEYLGSF 1922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	96/245 (39%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	72/250 (29%)
ptprfb	XP_009296732.1	I-set	35..126	CDD:254352
		Ig2_RPTP_IIa_LAR_like	155..233	CDD:319301
		Ig3_RPTP_IIa_LAR_like	261..329	CDD:143216
		FN3	334..423	CDD:238020
		FN3	430..522	CDD:238020
		FN3	527..615	CDD:238020
		FN3	623..717	CDD:238020
		fn3	725..823	CDD:306538
		FN3	835..916	CDD:238020
		FN3	933..1021	CDD:238020
		PTPc	1397..1626	CDD:238006	95/243 (39%)
		PTPc	1687..1917	CDD:238006	71/248 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810