Protein Alignment Ptp36E and PTPRZ1

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_002842.2
• Gene: PTPRZ1 / 5803
• HGNCID: 9685
• Length: 2315
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 186/630 - (29%)
• Similarity: 305/630 - (48%)
• Gaps: 79/630 - (12%)

  Fly    81 GPIDIRHFLK-LCDLRRKFPVLYKLEFQTAAKV--ESNTCRHAL--------KKNNLEKNQNPKC 134
            |.|.|:||.| :.||.....  :..||:|..:.  |..:|...|        ..:|..||:....
Human  1697 GAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINI 1759

  Fly   135 IPYDYNRVVL----EKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISA 195
            :.||::||.|    ||.|.|  :||:||:|||...:|.|||..|||::.|.:.:|||:|:.|:..
Human  1760 VAYDHSRVKLAQLAEKDGKL--TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEV 1822

  Fly   196 IVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRL----YKMNEKQEV 256
            |||:|...:..:..|.||||  .:..|:||:..:.....:.||.:.:|.|.|    .|...::..
Human  1823 IVMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGR 1885

  Fly   257 TDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVY 320
            ...|::.|:|||:|.....| :|..:|.|.|:......:.:       ||::||||.|.||:|.|
Human  1886 PSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAV-------GPVVVHCSAGVGRTGTY 1943

  Fly   321 MSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSEL--- 382
            :.:|:.|:..:.|...|:||:||.:|..|..||:..|||.||:|||.|.|:..:|....|.:
Human  1944 IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAY 2008

  Fly   383 ---------SDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCV 438
                     :.:.|.:.:....::.|..|::|....||        |       ||||||....:
Human  2009 VNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQ--------C-------NREKNRTSSII 2058

  Fly   439 PPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLC 503
            |.:..|..::|..|.. |||||:.::.||.:..|:|:|:.|:.||:.:||.:::|.....||::.
Human  2059 PVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP 2122

  Fly   504 QPPSQSQQYPSFWPNKSKMEKYGPV----FSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVK 564
            ...:.::....:||||.:     |:    |.| .:|::.:..:...|    |.|:....:.|...
Human  2123 DGQNMAEDEFVYWPNKDE-----PINCESFKV-TLMAEEHKCLSNEE----KLIIQDFILEATQD 2177

  Fly   565 APTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANA 629
            .....|:.||...||......|.|..|:.::......|:    ||:.|....|...||.:||...
Human  2178 DYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRD----GPMIVHDEHGGVTAGTFCALTT 2238

  Fly   630 CIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674
            .:.|:.:...|||:|..|.:...||.:..::.:|::.|.::|..|
Human  2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV 2283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	92/251 (37%)
		Y_phosphatase	428..671	CDD:459674	67/246 (27%)
PTPRZ1	NP_002842.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:394996
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..507
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..650
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1123..1160
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1397..1523
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1543..1572
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1584..1621
		PTP_DSP_cys	1717..1994	CDD:475123	99/287 (34%)
		R-PTP-Z-2	2077..2280	CDD:350507	55/216 (25%)