DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp36E and PTPRF

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_005271136.1	Gene:	PTPRF / 5792	HGNCID:	9670	Length:	1922	Species:	Homo sapiens

Alignment Length:	671	Identity:	193/671 - (28%)
Similarity:	323/671 - (48%)	Gaps:	91/671 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DDVEKQ----QRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGPIDIRHFL 89
            |.||.:    |....::.|.|||..:                 ||          :.||.|   .
Human  1316 DPVEMRRLNYQTPGSSVPSCPNTSSM-----------------RD----------HPPIPI---T 1350

  Fly    90 KLCD----LRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGL 150
            .|.|    |:....:.:..|:::....:..|..::..:.|..||:....|.||::||:|..:.|:
Human  1351 DLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV 1415

  Fly   151 QDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWP 215
            ..|||:||:|:|...|.||||.||||:.||:..:|||||::..:.:||:|:..:.::|.|.||||
Human  1416 PGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP 1480

  Fly   216 PNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCP-FSN 279
            ....  |..|.|.:.::...:||.:.:|||.|:|...    :::|.:.||.:..|..|..| :..
Human  1481 ARGT--ETCGLIQVTLLDTVELATYTVRTFALHKSGS----SEKRELRQFQFMAWPDHGVPEYPT 1539

  Fly   280 ALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKK 344
            .:|.|.|||:..  |.:.     .||::||||.|.||:|.::.|||.||..:.|:..:::|::..
Human  1540 PILAFLRRVKAC--NPLD-----AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTC 1597

  Fly   345 LRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQIC 409
            :|..|..:|:..:||.||::.|.|...||.|..|...|...::...:...|..:...:.|:..:.
Human  1598 MRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLA 1662

  Fly   410 K---QTPRFTIGD--CAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTK 469
            .   .|.||...:  |       |:.|||.|..:|.:..|..|...:|...:||||:.|:|||.:
Human  1663 SSKAHTSRFISANLPC-------NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQ 1720

  Fly   470 PREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWP-NKSKMEKYGPVFSVH 532
            .:.||.|:.|:..:..:||.::::...:.:|:|.:..... ::...:|| .:|...:|      .
Human  1721 QKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQY------F 1779

  Fly   533 YVMSKSYTNIKQW---EFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYL 594
            .|...:..|:.|:   |||:       |:...|   .:||::.||.|.|| ...||.:....:..
Human  1780 VVDPMAEYNMPQYILREFKV-------TDARDG---QSRTIRQFQFTDWP-EQGVPKTGEGFIDF 1833

  Fly   595 MNMVEIWRNKVDY---GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQL 656
            :..|.  :.|..:   ||:.|....|..|.||:...:..:|::...|.||:||.|||:|..||.:
Human  1834 IGQVH--KTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAM 1896

  Fly   657 VENMTEYKYCYDLVLHYVLHF 677
            |:...:|:.||...|.|:..|
Human  1897 VQTEDQYQLCYRAALEYLGSF 1917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	89/243 (37%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	71/250 (28%)
PTPRF	XP_005271136.1	I-set	33..124	CDD:254352
		Ig	50..121	CDD:143165
		I-set	135..225	CDD:254352
		Ig2_RPTP_IIa_LAR_like	152..226	CDD:143215
		IG_like	242..319	CDD:214653
		Ig3_RPTP_IIa_LAR_like	250..318	CDD:143216
		FN3	323..412	CDD:238020
		FN3	419..511	CDD:238020
		FN3	516..605	CDD:238020
		fn3	613..700	CDD:278470
		FN3	714..820	CDD:238020
		FN3	825..914	CDD:238020
		FN3	923..1011	CDD:238020
		FN3	1020..>1079	CDD:238020
		PTPc	1366..1621	CDD:214550	91/267 (34%)
		PTPc	1392..1621	CDD:238006	88/241 (37%)
		PTPc	1657..1912	CDD:214550	76/280 (27%)
		PTPc	1682..1912	CDD:238006	70/248 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810