DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp36E and PTPRC

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens

Alignment Length:	649	Identity:	184/649 - (28%)
Similarity:	320/649 - (49%)	Gaps:	76/649 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ERIKLEARDENNSLSKTIP-NGPIDIRHF-LKLCDLRRKFPVLYKLEFQTAAKVESN-TCRHALK 122
            |:.:|..||:...|....| :..|.:..: .|:.|..|    |:..|||:..:|.|. ..:.|.|
Human   614 EQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGR----LFLAEFQSIPRVFSKFPIKEARK 674

  Fly   123 KNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRM 187
            ..|..||:....:|||||||.|.::.|...|:|:||||:|...:|..||..|||.:|||..:|||
Human   675 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRM 739

  Fly   188 VWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNE 252
            :|::..:.|||:|:..:..:..|.:|||...|....:||:.:.|.:.::..::.|:  :|..:|:
Human   740 IWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQ--KLNIVNK 802

  Fly   253 KQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGR 316
            |::.|. |.:....:|.|..|..|.. :.||:.||||. ...|...      |||:||||.|.||
Human   803 KEKATG-REVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-AFSNFFS------GPIVVHCSAGVGR 859

  Fly   317 SGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSE 381
            :|.|:.|||.||..|.|...:|:||:.|||:.|..:|:...||..|:..|.|:...|:|...:||
Human   860 TGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 924

  Fly   382 LSDRLKAKARRNSGTKMNEYQAEYDQICK----QTPRFTIGDCAGGHRADNREKNRDVLCVPPDN 442
            |...|....:|:..::.:..:||:.::..    :|...       |::.:|:.|||:...:|.|.
Human   925 LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-------GNQEENKSKNRNSNVIPYDY 982

  Fly   443 FRPYL---------TSFQGNAFTD----------YINSVFVDGYTKPREYIVTEWPMKHTLGEFW 488
            .|..|         :....:..:|          |||:.|:..|.||...|..:.|:|.|:|:||
Human   983 NRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 1047

  Fly   489 SLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKI 553
            .:::.::...:|:|.:.....|:..:.:..:.| :.||.:          ..::|..: |.:...
Human  1048 QMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK-QTYGDI----------EVDLKDTD-KSSTYT 1100

  Fly   554 VSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDY----------- 607
            :.:.|:....:..:|||..:|.|.|.: .::|:....|:   :|:::.:.|:..
Human  1101 LRVFELRHSKRKDSRTVYQYQYTNWSV-EQLPAEPKELI---SMIQVVKQKLPQKNSSEGNKHHK 1161

  Fly   608 -GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLV 670
             .|:.:...||..:.|::||....:|.......||:||.||.:|:.||.:|....:|::.||::
Human  1162 STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	92/243 (38%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	62/274 (23%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163
		PHA03255	81..>231	CDD:165513
		CD45	237..295	CDD:372194
		FN3	392..462	CDD:238020
		FN3	485..565	CDD:238020
		R-PTPc-C-1	707..907	CDD:350405	78/209 (37%)
		Substrate binding. /evidence=ECO:0000250	853..859		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		1/20 (5%)
		R-PTP-C-2	1017..1223	CDD:350406	51/221 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810