Protein Alignment Ptp36E and PTPN1

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 85/286 - (29%)
• Similarity: 136/286 - (47%)
• Gaps: 42/286 - (14%)

  Fly    84 DIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVG 148
            ||||  :..|    ||                 ||.|....|..:|:.....|:|::|:.|.:
Human    22 DIRH--EASD----FP-----------------CRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ-- 61

  Fly   149 GLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQY 213
              :|:||:|||.:.......:||:||||:..|...:|.|||::....:|||.:..:...:.|.||
Human    62 --EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY 124

  Fly   214 WPPNMEVHEQYGD--IFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCP 276
            ||...|....:.|  :.:.::.|:..:.:.:|...|    |.....:.|.||.||||.|.....|
Human   125 WPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL----ENLTTQETREILHFHYTTWPDFGVP 185

  Fly   277 FSNA-LLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEE---CFN 337
            .|.| .|.|..:|| ..|::..:    .||::||||.|.||||.:...|..|.|.::.:   ..:
Human   186 ESPASFLNFLFKVR-ESGSLSPE----HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVD 245

  Fly   338 VFGYLKKLRQSRKGLVENVEQYKFIY 363
            :...|.::|:.|.||::..:|.:|.|
Human   246 IKKVLLEMRKFRMGLIQTADQLRFSY 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	75/245 (31%)
		Y_phosphatase	428..671	CDD:459674
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	85/286 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398