Protein Alignment Ptp36E and ptpn22

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001092890.2
• Gene: ptpn22 / 565606
• ZFINID: ZDB-GENE-060503-458
• Length: 901
• Species: Danio rerio
• Alignment Length: 592
• Identity: 156/592 - (26%)
• Similarity: 239/592 - (40%)
• Gaps: 160/592 - (27%)

  Fly    66 EARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLE--FQTAAKVESNTCRHALKKNNLEK 128
            ||.||      |..||  ....||||    ::....|:.|  :.|.|         |.|::|::|
Zfish    19 EAEDE------TAENG--FAGEFLKL----KRQSTKYRAERTYPTTA---------ADKQDNVKK 62

  Fly   129 NQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENI 193
            |:....:|:|::||.|.......|:||:|||::..:....|||.||||:..||..:|||:|:.||
Zfish    63 NRYKDIVPFDHSRVKLSLFTSKNDTDYINASFIKGVSGSKAYIATQGPLSNTVLDFWRMIWEYNI 127

  Fly   194 SAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFI----NIVRE--EQLANFHIRTFRLYKMNE 252
            ..|||:.:.|:..:..|.:|||      |..||:|:    .|:.|  |...::..||.   |:..
Zfish   128 KVIVMVCREFEMGRKKCERYWP------ESKGDVFVCEAFTILYESDENKGDYLTRTL---KVTF 183

  Fly   253 KQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGR 316
            |||   .|.:.|.||..|..|..|.| .|:||..:.:|     |.:|.:::  ||.:|||.|.||
Zfish   184 KQE---SRRLKQLHYVNWPDHGVPDSIPAILELLQEMR-----IYQDNEEI--PICIHCSAGCGR 238

  Fly   317 SGVYMSIDANLELAEEE---ECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL----EEHIICGK 374
            :|...:||....|.:.:   |.|::|..:|.:|..|..:|:..|||:.:|.|:    |.::...:
Zfish   239 TGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVVQTKEQYELVYRTIKLLFERYLAALE 303

  Fly   375 TWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRAD-------NREKN 432
            .  |.:::.|. .:.|..:||:::::.....||  :||.          ||.|       |....
Zfish   304 A--PSNKVPDS-SSPAMLSSGSELSDISDFSDQ--EQTE----------HRNDEIRVDEYNHVMQ 353

  Fly   433 RDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECS 497
            .......|.: :|:......|..|             |.:.        |.....|..:.||...
Zfish   354 NSASWQQPHS-QPFSPEVMSNKLT-------------PADL--------HNARCEWVQITDQSSF 396

  Fly   498 AVVVL------C--QPPSQS------------QQYP-SF----WPNKSKME-----KYGPVFSVH 532
            ...||      |  |.|..|            ..|| ||    .|||..:|     :..||...|
Zfish   397 IAPVLQTDFTTCGSQKPDASTSLSTTSTQVSCSNYPISFVEELKPNKEHLEWVENQEASPVVKDH 461

  Fly   533 YVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNM 597
            ..:..|            ...:::.:...|.::|                  |.|.|..|.....
Zfish   462 NTVIPS------------TLCLTVEDPYFGPESP------------------PGSNNPSVLNCTA 496

  Fly   598 VEIWRNK 604
            .|||..|
Zfish   497 HEIWTEK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	88/256 (34%)
		Y_phosphatase	428..671	CDD:459674	38/207 (18%)
ptpn22	NP_001092890.2	None