Protein Alignment Ptp36E and ptpn11b

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001015717.1
• Gene: ptpn11b / 548434
• XenbaseID: XB-GENE-6054495
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 485
• Identity: 124/485 - (25%)
• Similarity: 198/485 - (40%)
• Gaps: 108/485 - (22%)

  Fly     8 GSSGAGGGKTGKHRSRSSARYD------DVEKQQ---RKSRAIVSIPNTIKLSMLNSGLLSFERI 63
            |....|||:          |:|      |..|:.   .||.|:|.:......:.:|:.
 Frog   178 GKYDVGGGE----------RFDTLTDLLDHYKKNPMVEKSGAVVHLKQPFNATRINAA------- 225

  Fly    64 KLEARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTC---RHALKKNN 125
            .:|.|                :|...|..|...|....:..||:...:.|....   :...:..|
 Frog   226 NIETR----------------VRELNKTADNTEKAKQGFWEEFEMLQQQECKLLYPRKEGQRPEN 274

  Fly   126 LEKNQNPKCIPYDYNRVVL----EKVGGLQDSDYVNASYVDSLLKP-------NAYIVTQGPVEE 179
            ..||:....:|:|..||.|    |.|.|   |||:||:|:.|.|..       ..||.|||.::.
 Frog   275 KSKNRYKNILPFDTTRVTLRDTDESVAG---SDYINANYIKSTLDEARGSQHYKVYIATQGCLQN 336

  Fly   180 TVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRT 244
            ||..:|.||:|||...|||.||..:.::..|.:|| |:....:.||.|.:..:..:|..::.:|.
 Frog   337 TVCDFWAMVYQENTHVIVMTTKEVERSRKKCFRYW-PDENCTKDYGCIRVQSLEVQQKKDYILRE 400

  Fly   245 FRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDMRGPILV 308
            .::.:|:   :|...|.|..:.|..|..|..|.. ..:|.|...:     |..:......|||:|
 Frog   401 LQISRMD---KVESPRPIWHYQYLSWPDHGVPIEPGGVLSFLEEI-----NAAQKYIPHSGPIVV 457

  Fly   309 HCSDGGGRSGVYMSIDANLELAEEE--EC-FNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI 370
            |||.|.||:|..:.||..:::...:  :| .::...::.:||.|.|:|:...||||||..::::|
 Frog   458 HCSAGIGRTGTIIVIDMLVDIINRQGLDCDIDIPKTIQMVRQQRSGMVQTEAQYKFIYMAVQKYI 522

  Fly   371 ICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCA----------GGHR 425
            ...|......::.   |.|.|            ||..|     ::::|:.|          ..||
 Frog   523 EVRKRHLEEEQMG---KLKER------------EYTNI-----QYSVGERARTKAQPAAAQSQHR 567

  Fly   426 ADNREKNRDVLCVPPD-NFRPYLTSFQGNA 454
            ..:     |..||..: |.|....|...||
 Frog   568 VSD-----DAACVYENLNIRSTHMSSTSNA 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	82/257 (32%)
		Y_phosphatase	428..671	CDD:459674	8/28 (29%)
ptpn11b	NP_001015717.1	SH2_N-SH2_SHP_like	5..103	CDD:198203
		SH2_C-SH2_SHP_like	111..219	CDD:198185	12/50 (24%)
		PTPc-N11_6	274..523	CDD:350392	82/260 (32%)