DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and PTPRQ

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_016874762.1	Gene:	PTPRQ / 374462	HGNCID:	9679	Length:	2536	Species:	Homo sapiens

Alignment Length:	402	Identity:	111/402 - (27%)
Similarity:	183/402 - (45%)	Gaps:	81/402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YDDVEK------QQRKSRAIVSIPNTI-KLSMLNSGLLSFERIK--------------------- 64
            |.|..|      .:|....|:|:...| .:.:|.:.:.:|.||:
Human  2110 YSDPVKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKL 2174

  Fly    65 ----------LEARDEN-------------------NSLSKTIPNGPIDIRHFL----KLCDLRR 96
                      ||.:||.                   .|..|:|.  ||..:.||    :||....
Human  2175 KLDQLITVADLELKDERLTRYSSFFFRRKEIFVIQLLSYRKSIK--PISKKSFLQHVEELCTNNN 2237

  Fly    97 KFPVLYKLEFQTAAK-VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASY 160
               :.::.||....| ::..:...|....|..||:.|...||:.|||.|.....:..|||:||||
Human  2238 ---LKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASY 2299

  Fly   161 VDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYG 225
            :...|.||.:|.||||:..||..:|||||:.....:||||:.|:..::.||||||.:.:....:|
Human  2300 ISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFG 2364

  Fly   226 DIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVR 289
            ||.|..:.|:...::.||..::.:..      |...:.|.::|.|..|..|.::| |:.|   |:
Human  2365 DIVITKLMEDVQIDWTIRDLKIERHG------DCMTVRQCNFTAWPEHGVPENSAPLIHF---VK 2420

  Fly   290 LVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVE 354
            ||..:...|..    |::||||.|.||:||::::|...:...:.:..:::|.:.:||..|..:|:
Human  2421 LVRASRAHDTT----PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQ 2481

  Fly   355 NVEQYKFIYDTL 366
            |:.||.|::..:
Human  2482 NLAQYIFLHQCI 2493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	83/243 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
PTPRQ	XP_016874762.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910