DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptprf

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_038966081.1	Gene:	Ptprf / 360406	RGDID:	3453	Length:	1928	Species:	Rattus norvegicus

Alignment Length:	654	Identity:	193/654 - (29%)
Similarity:	322/654 - (49%)	Gaps:	71/654 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LNSGLLSFERIKLEARDEN----NSLSKTIPN-------GPIDIRHFLKLCD----LRRKFPVLY 102
            |...||:.....:|.|..|    .|.:.:.||       .||.|   ..|.|    |:....:.:
  Rat  1312 LKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPI---TDLADNIERLKANDGLKF 1373

  Fly   103 KLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKP 167
            ..|:::....:..|..::..:.|..||:....|.||::||:|..:.|:..|||:||:|:|...|.
  Rat  1374 SQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQ 1438

  Fly   168 NAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIV 232
            ||||.||||:.||:..:|||||::..:.:||:|:..:.::|.|.||||....  |.||.|.:.:|
  Rat  1439 NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGT--ETYGLIQVTLV 1501

  Fly   233 REEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNII 296
            ...:||.:.:|||.|:|...    :::|.:.||.:..|..|..| :...:|.|.|||:..  |.:
  Rat  1502 DTVELATYTMRTFALHKSGS----SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--NPL 1560

  Fly   297 KDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKF 361
            .     .||::||||.|.||:|.::.|||.||..:.|:..:::|::..:|..|..:|:..:||.|
  Rat  1561 D-----AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF 1620

  Fly   362 IYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICK---QTPRFTIGD--CA 421
            |::.|.|..:||.|......|...::...:...|..:...:.|:..:..   .|.||...:  |
  Rat  1621 IHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPC- 1684

  Fly   422 GGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGE 486
                  |:.|||.|..:|.:..|..|...:|...:||||:.|:|||.:.:.||.|:.|:..:..:
  Rat  1685 ------NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1743

  Fly   487 FWSLVYDQECSAVVVLCQPPSQS-QQYPSFWP-NKSKMEKYGPVFSVHYVMSKSYTNIKQW---E 546
            ||.::::...:.:|:|.:..... ::...:|| .:|...:|      ..|...:..|:.|:   |
  Rat  1744 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQY------FVVDPMAEYNMPQYILRE 1802

  Fly   547 FKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDY---G 608
            ||:       |:...|   .:||::.||.|.|| ...||.:....:..:..|.  :.|..:   |
  Rat  1803 FKV-------TDARDG---QSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVH--KTKEQFGQDG 1854

  Fly   609 PVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY 673
            |:.|....|..|.||:...:..:|::...|.||:||.|||:|..||.:|:...:|:.||...|.|
  Rat  1855 PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1919

  Fly   674 VLHF 677
            :..|
  Rat  1920 LGSF 1923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	91/243 (37%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	71/250 (28%)
Ptprf	XP_038966081.1	I-set	33..124	CDD:400151
		Ig strand A	33..36	CDD:409353
		Ig strand A'	42..45	CDD:409353
		Ig strand B	50..57	CDD:409353
		Ig strand C	63..68	CDD:409353
		Ig strand C'	71..73	CDD:409353
		Ig strand D	80..84	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	103..111	CDD:409353
		Ig strand G	114..124	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	136..232	CDD:409400
		Ig strand B	152..156	CDD:409400
		Ig strand C	165..169	CDD:409400
		Ig strand E	196..200	CDD:409400
		Ig strand F	210..215	CDD:409400
		Ig strand G	222..225	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	245..326	CDD:409401
		Ig strand B	259..263	CDD:409401
		Ig strand C	272..276	CDD:409401
		Ig strand E	293..297	CDD:409401
		Ig strand F	305..310	CDD:409401
		Ig strand G	318..321	CDD:409401
		FN3	329..418	CDD:238020
		FN3	425..517	CDD:238020
		FN3	522..611	CDD:238020
		FN3	619..713	CDD:238020
		FN3	720..826	CDD:238020
		FN3	831..920	CDD:238020
		FN3	929..1017	CDD:238020
		FN3	1026..>1085	CDD:238020
		PTP_DSP_cys	1356..1631	CDD:421693	97/287 (34%)
		R-PTP-F-2	1633..1923	CDD:350477	81/315 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810