Protein Alignment Ptp36E and clr-1

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001022209.1
• Gene: clr-1 / 3565419
• WormBaseID: WBGene00000548
• Length: 1444
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 191/695 - (27%)
• Similarity: 301/695 - (43%)
• Gaps: 128/695 - (18%)

  Fly    64 KLEARD--ENNSLSKTIPNGPID-------IRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRH 119
            |:.::|  |...|.:|....|:|       :||        |....|:..|:::....:.:|..
 Worm   789 KMTSKDVVERTLLKQTFGAIPVDDLPTEYVVRH--------RDTDFLFAQEYESLPHFQLDTVA- 844

  Fly   120 ALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAY 184
            :.:|.|..||:......:|..||.|:|:.|...|||:||:::.|..:...:|..|.||:.|:..:
 Worm   845 SNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDF 909

  Fly   185 WRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFH----IRTF 245
            |||||::....|||:....:..:..|.:|||.  |...:||||.:    |....:||    ||.|
 Worm   910 WRMVWEQESYLIVMVANLTEKNRQQCAKYWPD--EQITRYGDIIV----EPASFSFHSDYAIRAF 968

  Fly   246 RLYKMNE---------------------KQEVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRV 288
            .:..:.|                     .|...:.|.|||:|:|.|..:..| .|..||.|..|:
 Worm   969 DIAHIGECGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRL 1033

  Fly   289 R-LVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGL 352
            | |...|        ..|:::|||.|.||:|.::|||:.|:....|:..|:|.::..||:.|..:
 Worm  1034 RELPQFN--------NSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLM 1090

  Fly   353 VENVEQYKFIYDTLEEHIICGKTWFPVSELSD---RLKAKARRNSGTKMNEYQAEYDQICKQTPR 414
            |:::|||.|||..|.|..:.|.|...|.:..|   ||.| :.|:.....|:..:....|   :||
 Worm  1091 VQSLEQYVFIYKALAEWHMYGDTDEDVRDFEDHYQRLCA-SNRDRAVSFNQQSSTNGSI---SPR 1151

  Fly   415 FTIGDCAGGHRADNRE------------------------------KNRDVLCVPPDNFRPYLTS 449
            ..|..........|.|                              |||....||.|.:|..|..
 Worm  1152 VAIVSSRESMTTSNGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPP 1216

  Fly   450 FQGNAFTDYINSVFVDGYTKPREYIVTEWPMKH-TLGEFWSLVYDQECSAVVVLCQPPSQSQQYP 513
            ..|:|.:.|||:..:.||.  .:||..:.|:.. |..:||.::.||..:.||:|.....
 Worm  1217 TIGHADSSYINASHIKGYF--FDYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLSDETD------ 1273

  Fly   514 SFWPNKSKMEKYGPV----FSVHYVMSKSYTNI------KQWEFKINKKIVSLTEMMAGVKAPTR 568
              |   |.:|||.|:    ...|:...::..|:      ...:|.|.....|:.: ...:.|...
 Worm  1274 --W---SDVEKYWPIDGSGTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYSMKD-NESMPANQE 1332

  Fly   569 TVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDYG---PVCVVSPDGRSRAGVY-CAANA 629
            .|| :..|.||....||.|.|||:.|:.|| :.|.....|   |:.|...:|.|.:|:: |.:..
 Worm  1333 VVQ-YSYTGWPSDSIVPKSANSLMNLIEMV-LQRQSSLMGSQAPIVVHCRNGSSESGIFICISLL 1395

  Fly   630 CIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674
            .:.|..:. .:||||.||.::.|||.:.....:|.:||..:..|:
 Worm  1396 WLRQKAEQ-RIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYI 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	87/269 (32%)
		Y_phosphatase	428..671	CDD:459674	75/287 (26%)
clr-1	NP_001022209.1	FN3	403..523	CDD:238020
		PTPc	827..1106	CDD:214550	91/293 (31%)
		PTPc	1169..1437	CDD:214550	73/284 (26%)