DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Pez

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	107/380 - (28%)
Similarity:	173/380 - (45%)	Gaps:	64/380 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSARYDDVEKQQR---KSRAIVSIPNTIKLSML------NSGLLSFERIKLE-ARDENNSLSKTI 78
            |||...|:::::|   .||:  ..|:..|.:.|      .:|..|....||: |:|:.|     :
  Fly   890 SSAASKDLKRKKRWNFLSRS--KTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLN-----L 947

  Fly    79 PN---------GPIDIRHFL-KLC---DLRRKFPVLYKLEFQTAAKVESNT---CRHALKKNNLE 127
            ||         .||..|:.. |||   |.:.....|: :||:...|...:.   |  ||.:.|..
  Fly   948 PNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLF-MEFERIPKRREHALYEC--ALLEENEP 1009

  Fly   128 KNQNPKCIPYDYNRVVLEKVGGLQDS--DYVNASYVDSLL--KPNAYIVTQGPVEE-TVQAYWRM 187
            ||.:|..:|||.|||   ::...:|:  .|||||.:.:.:  |...|||.|.|.|. |::.:|:.
  Fly  1010 KNHDPNFLPYDDNRV---RLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQC 1071

  Fly   188 VWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRT--FRLYKM 250
            ||:.::..:|.||:..        .|.|.|.....::|.  ..:.:|.........|  .|||.:
  Fly  1072 VWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQ--FQVYQEFSQTTDRCTTIKLRLYHV 1126

  Fly   251 NEKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRR---VRLVVGNIIKDEDDMRGPILVHCS 311
            ..::    .|.:....|.:|...:||.. |..|:|...   |||.....:....:...|:|:||.
  Fly  1127 PSRR----YRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCL 1187

  Fly   312 DGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL 366
            :|||||||.::.|..|...:..|..::...:.:||..|..::.::.||||||:.|
  Fly  1188 EGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLL 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	74/253 (29%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Pez	NP_001260127.1	B41	26..230	CDD:214604
		FERM_N	26..93	CDD:286467
		FERM_M	114..230	CDD:278785
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		Y_phosphatase	1007..1243	CDD:278528	74/253 (29%)
		PTPc	1009..1243	CDD:238006	73/251 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840