DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptp10D

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	136/470 - (28%)
Similarity:	219/470 - (46%)	Gaps:	74/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TGKHRSRSSARYDDVEKQQRKSRAIVSI--PNTIKLSMLNSGLLSFERIKLEAR--------DEN 71
            ||..:...:|....::..|..:..||:|  |.||.|.:|.: ||.::|.:...|        ::|
  Fly  1175 TGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVT-LLFYKRRRNNCRKTTKDSRANDN 1238

  Fly    72 NSLSKTI--PNGPIDIRHF---LKLCDLRRKFPVLYKLEFQTAAKV-ESNTCRHALKKNNLEKNQ 130
            .||..::  .|.||.|::|   .:|......|  .:..||:....| ....|..|....|..||:
  Fly  1239 MSLPDSVIEQNRPILIKNFAEHYRLMSADSDF--RFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301

  Fly   131 NPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISA 195
            ....:|||::|..|:.|...:.|||:||:||.....|..:||||||:..|...:|||.|:.|..|
  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366

  Fly   196 IVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDER 260
            |||||:.|:..:..|.||| ||..|...||||.:.|:.:...|::.:..|.|.:.:|      :|
  Fly  1367 IVMLTRCFEKGREKCDQYW-PNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSE------QR 1424

  Fly   261 LILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSID 324
            ::..||:|.|.....|. ...|:.|.|..|..:|      .:.| ||:||||.|.||||.::::|
  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIG------AEQR-PIVVHCSAGVGRSGTFITLD 1482

  Fly   325 ANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL------EEHIICGKTWFPVSELS 383
            ..|:.....:..::||.:..:|:.|..:|:..:||..|:..|      :|:|:     .|..|:.
  Fly  1483 RILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIV-----GPAREMH 1542

  Fly   384 DRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAG---GH-------RADNREKNRDVLCV 438
            |        |.|     |:.:..|:.:.      ||...   ||       :|:....:.:...:
  Fly  1543 D--------NEG-----YEGQQVQLDEN------GDVVATIEGHLSHHDLQQAEAEAIDDENAAI 1588

  Fly   439 PPDNFRPYLTSFQGN 453
            ..|:.:|..:||.|:
  Fly  1589 LHDDQQPLTSSFTGH 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	86/249 (35%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	5/26 (19%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	90/266 (34%)
		PTPc	1298..1525	CDD:238006	84/240 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940