DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	117/450 - (26%)
Similarity:	190/450 - (42%)	Gaps:	130/450 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AATGGGSSGAG-----------GGKTGKHRSRSSARYDDVEKQQRKSRAIVSIPNTIKLSMLNSG 56
            :|:||.::.|.           .|.:..||..::       .....|.:..::.|.:||:...|.
  Fly   402 SASGGATTAASAATEPNENITINGLSPSHRQAAN-------NSSSSSSSAATVANPLKLNTSGSA 459

  Fly    57 LLSFERIKLEARDENNSLSK-------------TIPNG--------------------------- 81
                        |.|::::.             |..||
  Fly   460 ------------DNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQE 512

  Fly    82 ----PIDI---------RHFL--KLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQN 131
                |||.         ||.|  :..|:|.:.|              ..|..||..:.||.||:.
  Fly   513 GDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAP--------------EGTFLHARMRANLTKNRY 563

  Fly   132 PKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAI 196
            ...:.||::||||....|.:.|||:||::||...:.||||.||||:.:|.|.:|||:|:::...|
  Fly   564 TDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVI 628

  Fly   197 VMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEV----- 256
            ||.|:..:..:|.|.|||.|..|...::||             :|:||..: :.||...|
  Fly   629 VMTTRVMERGRVKCGQYWEPTEESSLEFGD-------------YHVRTISV-ECNEDYMVASLEL 679

  Fly   257 ----TDE-RLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDM-----RG-PILVH 309
                ||| |.:..:.:|.|..:..|.| .|:|.|.::||.....:::...|.     || ||:||
  Fly   680 RNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVH 744

  Fly   310 CSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH 369
            ||.|.||:|.::::|..:...|:....::.|.::|:|..|...::..:||.|.:..|.|:
  Fly   745 CSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	87/259 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	87/259 (34%)
		PTPc	559..803	CDD:238006	85/257 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940